Penn-made AI Tool Aims to Treat Rare Diseases with Existing Drugs

Castleman’s disease is a lymph node disorder characterized by swelling that can damage internal organs. One patient was about to head into hospice care, after all treatments had failed. With the help of an artificial intelligence platform developed by David Fajgenbaum, MD, an associate professor of Translational Medicine and Genetics, and his colleagues, a medication already approved by the FDA for other uses was identified as a possible new treatment and has since kept the patient in remission for two years.