Breakthrough Discovery in Autoimmune Disease Research

Researchers at the University of Pennsylvania, led by Dr. Jonathan Miner, have identified a key protein, ArfGAP2, that assists the STING protein in regulating cell acidity within the Golgi apparatus—a crucial factor in controlling immune responses. This discovery opens new avenues for treating autoimmune diseases like SAVI, where malfunctioning STING proteins cause severe, early-onset inflammation. By targeting ArfGAP2, scientists significantly reduced inflammation in lab models, offering hope for future therapies.