Combination Anti-PD-1 and Anti-CTLA-4 Therapy Generates Waves of Clonal Responses That Include Progenitor-Exhausted CD8+ T Cells

Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, Nandi A, Anderson S, Han N, Manne S, Kiner E, Sachar C, Lucas M, George S, Yan PK, Kier MW, Laughlin AI, Kothari S, Giles J, Mathew D, Ghinnagow R, Alanio C, Flowers A, Xu W, Tenney DJ, Xu X, Amaravadi RK, Karakousis GC, Schuchter LM, Buggert M, Oldridge D, Minn AJ, Blank C, Weber JS, Mitchell TC, Farwell MD, Herati RS, Huang AC.

Cancer Cell. 2024 Sep 9;42(9):1582-1597.e10. Epub 2024 Aug 29. PMID: 39214097