Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.

Jin GB, Rong SQ, Yin DR, Deng ZH, Ding X, Sheng MY, Gao H, Kohli RM, Xu GL, Zhou D. Proc Natl Acad Sci U S A. 2025 Feb 4;122(5):e2418318122. doi: 10.1073/pnas.2418318122. Epub 2025 Jan 28. PMID: 39874291