Mission

The primary objective of our lab is to unveil the mystery of sleep. By integrating diverse experimental and computational tools—including electrophysiology, two-photon imaging, proteomics, numerical modeling, and artificial intelligence—we aim to develop a coherent theory to explain the function and origin of sleep. Currently, we are focused on advancing the self-cleansing brain hypothesis for sleep, which also provides profound insights into neurodegenerative disorders.

Newly established in 2025, our lab is part of the Department of Neuroscience and affiliated with the Chronobiology and Sleep Institute at the University of Pennsylvania (Penn). Located in Philadelphia, a historic city celebrated for its rich culture and humanities, Penn is internationally recognized for its pioneering and interdisciplinary research in neuroscience, sleep, and neurodegeneration. We are currently seeking talented and motivated individuals to join our team, including postdoctoral fellows, research specialists, technicians, as well as graduate and undergraduate students.