Perelman School of Medicine at the University of Pennsylvania

Kaestner Lab

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Publications

For a complete pubmed list of Kaestner Lab publications, please visit here.

List of selected publications:

 

2020

Fasolino M, Goldman N, Wang W, Cattau B, Zhou Y, Petrovic J, Link VM, Cote A, Chandra A, Silverman M, Joyce EF, Little SC; HPAP Consortium, Kaestner KH, Naji A, Raj A, Henao-Mejia J, Faryabi RB, Vahedi G. Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression. Immunity. 2020

Wang AW, Wang YJ, Zahm AM, Morgan AR, Wangensteen KJ, Kaestner KH.The Dynamic Chromatin Architecture of the Regenerating Liver. Cell Mol Gastroenterol Hepatol. 2020

 

2019

Zahm AM, Wang AW, Wan YJ, Schug J, Wangensteen KJ, Kaestner KH.High-Content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice. Gastroenterology. 2019

Kaestner KH, Powers AC, Naji A; HPAP Consortium, Atkinson MA. NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP). Diabetes. 2019

Wang YJ, Traum D, Schug J, Gao L, Liu C; HPAP Consortium, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH.Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes. Cell Metab. 2019

Ou K, Yu M, Moss NG, Wang YJ, Wang AW, Nguyen SC, Jiang C, Feleke E, Kameswaran V, Joyce EF, Naji A, Glaser B, Avrahami D, Kaestner KH.Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication. J Clin Invest. 2019

 

2018

Kameswaran V, Golson ML, Ramos-Rodríguez M, Ou K, Wang YJ, Zhang J, Pasquali L, Kaestner KH. The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs. Diabetes. 2018

Ackermann AM, Moss NG, Kaestner KH.GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo. Cell Metab. 2018

Terry NA, Ngaba LV, Wilkins BJ, Pi D, Gheewala N, Kaestner KH.Lipid malabsorption from altered hormonal signaling changes early gut microbial responses. Am J Physiol Gastrointest Liver Physiol. 2018

Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, Wang A, Kieckhaefer J, Li C, Pikarsky E, Levin-Klein R, Goren A, Rajewsky K, Kaestner KH, Cedar H.Postnatal DNA demethylation and its role in tissue maturation. Nat Commun. 2018

Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massasa EE, Itzkovitz S, Kaestner KH. Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature. 2018

Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH.Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice. Mol Metab. 2018

Wang AW, Wangensteen KJ, Wang YJ, Zahm AM, Moss NG, Erez N, Kaestner KH.TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. J Clin Invest. 2018

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH.Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology. 2018

 

2017

Swisa A, Kaestner KH, Dor Y.Transcriptional Noise and Somatic Mutations in the Aging Pancreas. Cell Metab. 2017

Ackermann AM, Zhang J, Heller A, Briker A, Kaestner KH.High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting. Mol Metab. 2017

 

2016

Kieckhaefer J, Lukovac S, Ye DZ, Lee D, Beetler DJ, Pack M, Kaestner KH.The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice.Cell Mol Gastroenterol Hepatol. 2016

Kim R, Sheaffer KL, Choi I, Won KJ, Kaestner KH.Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation. Genes Dev. 2016

Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metab. 2016

Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M.Human islets contain four distinct subtypes of β cells. Nat Commun. 2016

Wang YJ, Schug J, Won KJ, Liu C, Naji A, Avrahami D, Golson ML, Kaestner KH.Single-Cell Transcriptomics of the Human Endocrine Pancreas. Diabetes. 2016

Shin S, Wangensteen KJ, Teta-Bissett M, Wang YJ, Mosleh-Shirazi E, Buza EL, Greenbaum LE, Kaestner KH.Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Hepatology. 2016

Ackermann AM, Wang Z, Schug J, Naji A, Kaestner KH.Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Mol Metab. 2016

Aoki R, Shoshkes-Carmel M, Gao N, Shin S, May CL, Golson ML, Zahm AM, Ray M, Wiser CL, Wright CV, Kaestner KH.Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cell Mol Gastroenterol Hepatol. 2016

Elliott EN, Sheaffer KL, Kaestner KH.The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium. Elife. 2016

 

2015

Ferreira MJ, McKenna LB, Zhang J, Reichert M, Bakir B, Buza EL, Furth EE, Bogue CW, Rustgi AK, Kaestner KH.Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cell Mol Gastroenterol Hepatol. 2015

Avrahami D, Li C, Zhang J, Schug J, Avrahami R, Rao S, Stadler MB, Burger L, Schübeler D, Glaser B, Kaestner KH.Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function. Cell Metab. 2015

Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH.Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development. 2015

Wangensteen KJ, Zhang S, Greenbaum LE, Kaestner KH.A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation. Genes Dev. 2015

Bernstein DL, Le Lay JE, Ruano EG, Kaestner KH.TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts. J Clin Invest. 2015