Welcome to Our Laboratory
The Liu Lab is affiliated with the Department of Biochemistry and Biophysics at the University of Pennsylvania Perelman School of Medicine.
From Nucleic Acid to Enzymes: Biochemical Discoveries Fueling Cancer Cures
Our lab studies how enzymes regulate gene expression differently in normal physiology and cancer biology. We discover unique biochemical mechanisms underlying cancer vulnerabilities. We combine deep mechanistic studies with innovative therapeutic development, from (1) X-Y paired homologous proteins, (2) cancer fusion proteins, (3) ribosome biology, and (4) coregulation of enzyme-mediated modifications across RNA species. We aim to redefine how molecular understanding leads to new cancer treatments by bridging fundamental biochemistry and translational research. Our goal is to forge a direct path from benchside discoveries to impactful clinical applications, fundamentally changing how we approach cancer treatment
Come join us!
We are constantly looking for talented and passionate researchers (postdocs, graduate students, undergraduate students, and research technicians) to join our growing team! Please get in touch with Dr. Liu (liufg@pennmedicine.upenn.edu) if interested.
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