Perelman School of Medicine at the University of Pennsylvania

Wenqin Luo Lab

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Suna L. Cranfill and Wenqin Luo: Nerve regrowth can be painful. Nature News & Views, May 2022. Read

Lian Cui, Jeff Guo*, Suna L. Cranfill*, Mayank Gautam, Janardhan Bhattarai, William Olson, Katherine Beattie, Rosemary C. Challis, Qinxue Wu, Xue Song, Tobias Raabe, Viviana Gradinaru, Minghong Ma, Qin Liu, and Wenqin Luo: Glutamate in primary afferents is required for itch transmission. Neuron, January 2022. Read

Katherine Beattie, Haowu Jiang, Mayank Gautam, Mary K. MacVittie, Barbara Miller, Minghong Ma, Qin Liu, and Wenqin LuoTRPC3 antagonizes pruritus in a mouse contact dermatitis model. Journal of Investigative Dermatology, September 2021. Read

Suna L. Cranfill and Wenqin Luo: The development of somatosensory neurons: Insights into pain and itch. Current Topics in Developmental Biology 142, 443-475, March 2021. Read

Huasheng Yu, Tianjun Zhao, Simin Liu, Qinxue Wu, Omar Johnson, Zhaofa Wu, Zihao Zhuang, Yaocheng Shi, Luxin Peng, Renxi He, Yong Yang, Jianjun Sun, Xiaoqun Wang, Haifeng Xu, Zheng Zeng, Peng Zou, Xiaoguang Lei, Wenqin Luo*, and Yulong Li*: MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife 8:e48431, September 2019. Read

Ishmail Abdus-Saboor*, Nathan T. Fried*, Mark Lay, Justin Burdge, Kathryn Swanson, Roman Fischer, Jessica Jones, Peter Dong, Weihua Cai, Xinying Guo, Yuan-Xiang Tao, John Bethea, Minghong Ma, Xinzhong Dong, Long Ding, and Wenqin LuoDevelopment of a mouse pain scale using sub-second behavioral mapping and statistical modeling. Cell Reports 28(6):1623-34, August 2019. Read

Arthi Prabhakar, Dragan Vujovic, Lian Cui, William Olson, and Wenqin LuoLeaky expression of channelrhodopsin-2 (ChR2) in Ai32 mouse lines. PLoS One 14(3):e0213326, March 2019. Read

Changming Wang, Leying Gu, Yonglan Ruan, Xiao Geng, Miao Xu, Niuniu Yang, Lei Yu, Yucui Jiang, Chan Zhu, Yan Yang, Yuan Zhou, Xiaowei Guan, Wenqin Luo, Xinzhong Dong, Guan Yu, Lei Lan, and Zongxiang TangFacilitation of MrgprD by TRP-A1 promotes neuropathic pain. The FASEB Journal 33(1):1360–73, January 2019. Read

William Olson and Wenqin LuoSomatotopic organization of central arbors from nociceptive afferents develops independently of their intact peripheral target innervation. The Journal of Comparative Neurology 526(18):3058–65, December 2018. Read

Kim Kridsada*, Jingwen Niu*, Parthiv Haldipur, Zhiping Wang, Long Ding, Jian J. Li, Anne G. Lindgren, Eloisa Herrera, Gareth M. Thomas, Victor V. Chizhikov, Kathleen J. Millen, and Wenqin LuoRoof plate-derived radial glial-like cells support developmental growth of rapidly adapting mechanoreceptor ascending axons. Cell Reports 23(10):2928–41, June 2018. Read

Andrew Moberly, Mary Schreck, Janardhan P. Bhattarai, Larry S. Zweifel, Wenqin Luo, and Minghong MaOlfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior. Nature Communications 9:1528, April 2018. Read

Ishmail Abdus-Saboor*, Nathan T. Fried*, Mark Lay, Peter Dong, Justin Burdge, Ming Lu, Minghong Ma, Xinzhong Dong, Long Ding, and Wenqin LuoHigh-speed imaging of paw withdrawal reflex to objectively assess pain state in mice. bioRxiv (preprint), February 2018. Read

Nadia Parmhans, Szilard Sajgo, Jingwen Niu, Wenqin Luo, and Tudor C. BareaCharacterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret. The Journal of Comparative Neurology 526(4):742–66, March 2018. Read

William Olson, Ishmail Abdus-Saboor*, Lian Cui*, Justin Burdge, Tobias Raabe, Minghong Ma, and Wenqin LuoSparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors. eLife 6:e29507, October 2017. Read

Peter Dong, Changxiong Guo, Shengxiang Huang, Minghong Ma, Qin Liu and Wenqin LuoTRPC3 is dispensable for β-alanine triggered acute itch. Scientific Reports 7:13869, October 2017. Read

Yiqun Yu, Andrew H. Moberly, Janardhan P. Bhattarai, Chen Duan, Qian Zheng, Fangqi Li, Hugh Huang, William Olson, Wenqin Luo, Tieqiao Wen, Hongmeng Yu, and Minghong MaThe stem cell marker Lgr5 defines a subset of postmitotic neurons in the olfactory bulb. The Journal of Neuroscience 37(39):9403–14, September 2017. Read

Michael S. Fleming, Jian J. Li, Daniel Ramos, Tong Li, David A. Talmage, Shin-ichi Abe, Silvia Arber and Wenqin LuoA RET-ER81-NRG1 signaling pathway drives the development of Pacinian corpuscles. The Journal of Neuroscience 36(40):10337–55, October 2016. Read

Lian Cui*, Xuerong Miao*, Lingli Liang, Ishmail Abdus-Saboor, William Olson, Michael S. Fleming, Minghong Ma, Yuanxiang Tao, and Wenqin LuoIdenfication of early RET+ deep dorsal horn spinal cord interneurons in gating pain. Neuron 91(5):1137–53, September 2016. Read

William Olson, Peter Dong, Michael Fleming, and Wenqin LuoThe specification and wiring of mammalian cutaneous low-threshold mechanoreceptors. WIREs Developmental Biology 5(3):389–404, May 2016. Read

Cheng-Chiu Huang, Yu Shin Kim, William P. Olson, Fengxian Li, Changxiong Guo, Wenqin Luo, Andrew J. W. Huang, and Qin LiuA histamine-independent itch pathway is required for allergic ocular itch. The Journal of Allergy and Clinical Immunology 137(4):1267–70, April 2016. Read

Michael S. Fleming*, Anna Vysochan*, Sónia Paixão, Jingwen Niu, Rüdiger Klein, Joseph M. Savitt, and Wenqin Luo: Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. eLife 4:e06828, April 2015. Read

Jingwen Niu*, Anna Vysochan*, and Wenqin LuoDual innervation of neonatal Merkel cells in mouse touch domes. PLoS ONE 9(3):e92027, March 2014. Read

Sónia Paixão, Aarathi Balijepalli, Najet Serradj, Jingwen Niu, Wenqin Luo, John H. Martin, and Rüdiger KleinEphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80(6):1407–20, December 2013. Read

Jingwen Niu, Long Ding, Jian J. Li, Hyukmin Kim, Jiakun Liu, Haipeng Li, Andrew Moberly, Tudor C. Badea, Ian D. Duncan, Young-Jin Son, Steven S. Scherer, and Wenqin LuoModality-based organization of ascending somatosensory axons in the direct dorsal column pathway. The Journal of Neuroscience 33(45):17691–709, November 2013. Read

Michael S. Fleming and Wenqin LuoThe anatomy, function, and development of mammalian Aβ low-threshold mechanoreceptors. Frontiers in Biology 8(4):408–20, August 2013. Read

Michael S. Fleming, Daniel Ramos, Seung Baek Han, Jianyuan Zhao, Young-Jin Son, and Wenqin LuoThe majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Molecular Pain 8:52, July 2012. Read

Lishi Li*, Michael Rutlin*, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, Richard Koerber, C. Jeffrey Woodbury, and David D. GintyThe functional organization of cutaneous low-threshold mechanosensory neurons. Cell 147(7):1615–27, December 2011. Read

Wenqin Luo, Hideki Enomoto, Frank L. Rice, Jeffrey Milbrandt, and David D. GintyMolecular identification of rapidly adapting mechanoreceptors and their developmental dependence on Ret signaling. Neuron 64(6):841–56, December 2009. Read

Wenqin Luo, S. Rasika Wickramasinghe, Joseph M. Savitt, John W. Griffin, Ted M. Dawson, and David D. GintyA hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of non-peptidergic DRG neurons. Neuron 54(5):739–54, June 2007. Read

Wenqin Luo, John Williams, Philip M. Smallwood, Jeffrey W. Touchman, Laura M. Roman LM, and Jeremy NathansProximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish. The Journal of Biological Chemistry 279(18):19286–93, April 2004. Read

Wenqin Luo, Nicholas Marsh-Armstrong, Amir Rattner, and Jeremy NathansAn outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase. The Journal of Neuroscience 24(11):2623–32, March 2004. Read

* Equal contribution.