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Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Elizabeth S. McDonald, Tien-Chi Pan, Dhruv K. Pant, Melissa A. Troester, Andrew V. Kossenkov, David A. Mankoff, Robert H. Mach, and Lewis A. Chodosh
Cancer Research Communications 2025, 226-239

Design and Synthesis of D₃R Bitopic Ligands with Flexible Secondary Binding Fragments: Radioligand Binding and Computational Chemistry Studies
Tian GL, Hsieh CJ, Taylor M, Lee JY, Luedtke RR, Mach RH
Molecules 2023, 1-13

Synthesis of bitopic ligands based on fallypride and evaluation of their affinity and selectivity towards dopamine D₂ and D₃ receptors
Tian GL, Hsieh CJ, Taylor M, Lee JY, Riad AA, Luedtke RR, Mach RH
European Journal of Medicinal Chemistry 2023, 1-18

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy
Ho Young Kim, Wai Kit Chia, Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J A Graham, Zsofia Lengyel-Zhand, Mark Schneider, Cosette Tomita, Marshall G Lougee, Hee Jong Kim, Vinayak V Pagar, Hsiaoju Lee, Catherine Hou, Benjamin A Garcia, E James Petersson, Jennifer O'Shea, Paul T Kotzbauer, Chester A Mathis, Virginia M-Y Lee, Kelvin C Luk, Robert H Mach
Journal of Medcinal Chemistry 2023, 12185-12202

In Silico Discovery and Subsequent Characterization of Potent 4RTauopathy Positron Emission Tomography Radiotracers
Thomas J. A. Graham, anton Lindberg, Junchao Tong, Jeffrey S. Stehouwer, Neil Vasdev, Robert H. Mach, and Chester A. Mathis
Journal of Medicinal Chemistry 2023, 10628-10638

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development
Chia-Ju Hsieh, Sam Giannakoulias, E. James Petersson and Robert H. Mach
Pharmaceuticals 2023 16 (317), 1-19

Identifcation of a Putative α‑synuclein Radioligand Using an in silico Similarity Search
Bieneke Janssen, Guilong Tian, Zsofa Lengyel‑Zhand, Chia‑Ju Hsieh, Marshall G. Lougee, Aladdin Riad, Kuiying Xu, Catherine Hou, Chi‑Chang Weng, Brian J. Lopresti, Hee Jong Kim, Vinayak V. Pagar, John J. Ferrie, Benjamin A. Garcia, Chester A. Mathis, Kelvin Luk, E. James Petersson, Robert H. Mach
Molecular Imaging and Biology 2023

Molecular Imaging of Pulmonary Inflammation in Users of Electronic and Combustible Cigarettes: A Pilot Study
Wetherill RR, Doot RK, Young AJ, Lee H, Schubert EK, Wiers CE, Leone FT, Mach RH, Kranzler HR, Dubroff JG
Journal of Nuclear Medicine 2023, 797-802

[¹⁸F]FluorThanatrace ([¹⁸F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Pantel AR, Gitto SB, Makvandi M, Kim H, Medvedv S, Weeks JK, Torigian DA, Hsieh CJ, Ferman B, Latif NA, Tanyi JL, Martin LP, Lanzo SM, Liu F, Cao Q, Mills GB, Doot RK, Mankoff DA, Mach RH, Lin LL, Simpkins F
Clinical Cancer Research 2023

Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D₃-Selective Antagonists
Kim HY, Lee JY, Hsieh CJ, Taylor M, Luedtke RR, Mach RH
International Journal of Molecular Science 2022, 1-27

[¹⁸F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice
Hsieh CJ, Hou C, Zhu Y, Lee JY, Kohli N, Gallagher E, Xu K, Lee H, Li S, McManus MJ, Mach RH
EJNMMI Research 2022, 1-13

Characterization of Sigma-2 Receptor-Specific Binding Sites Using [³H]DTG and [¹²⁵I]RHM-4
Weng CC, Riad A, Lieberman BP, Xu K, Peng X, Mikitsh JL, Mach RH
Pharmaceuticals 2022, 1-9

Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma
Makvandi M, Samanta M, Martorano P, Lee H, Gitto SB, Patel K, Groff D, Pogoriler J, Martinez D, Riad A, Dabagian H, Zaleski M, Taghvaee T, Xu K, Lee JY, Hou C, Farrel A, Batra V, Carlin SD, Powell DJ Jr, Mach RH, Pryma DA, Maris JM
Communications Biology 2022, 1-9

[¹⁸F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson's Disease
Doot RK, Young AJ, Nasrallah IM, Wetherill RR, Siderowf A, Mach RH, Dubroff JG
Cells 2022, 1-10

Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
Xu K, Hsieh CJ, Lee JY, Riad A, Izzo NJ, Look G, Catalano S, Mach RH
International Journal of Molecular Science 2022, 1-13

Screening of σ₂ Receptor Ligands and In Vivo Evaluation of ¹¹C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ₂ Receptor Brain PET Tracer
Kim HY, Lee JY, Hsieh CJ, Riad A, Izzo NJ, Catalano SM, Graham TJA, Mach RH
Journal of Medicinal Chemistry 2022, 6261-6272

The Development of ¹⁸F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1
Lee HS, Schwarz SW, Schubert EK, Chen DL, Doot RK, Makvandi M, Lin LL, McDonald ES, Mankoff DA, Mach RH
Radiology: Imaging Cancer 2022, 1-11

PARkinson's: From cellular mechanisms to potential therapeutics
Lengyel-Zhand Z, Puentes LN, Mach RH
Pharmacology & Therapeutics 2022, 1-10

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples
Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider Jr., Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski and Robert H. Mach
Frontiers in Aging Neuroscience 2021 13 (704041), 1-14

Synthesis and characterization of high affinity fluorogenic a-synuclein probes
Zsofia Lengyel-Zhand, John J. Ferrie, Bieneke Janssen, Chia-Ju Hsieh, Thomas Graham, Kui-ying Xu, Conor M. Haney, Virginia M.-Y. Lee, John Q. Trojanowski, E. James Petersson and Robert H. Mach
ChemComm 2020 56, 3567-3570