Molecular Mechanisms Underlying Neuronal Development and Mental Disorders

Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.

Join our Lab

If you are enthusiastic about stem cell and neuroscience research and interested in joining as a Postdoctoral Fellow, Graduate Student or Undergraduate Student, please contact us about current opportunities within our lab.


2023 BRAIN Initiative Show Us Your BRAINS! Photo and Video Contest

Congratulations to Joey Zhou for having his photo submission of Human Hippocampal immature neurons be selected to feature in the 2024 BRAIN calendar! 



August 2023 

Jessica Cassin Awarded K99

Congratulations to Jessica Cassin, our former graduate student, for being given a K99 grant! This grant is designed for postdoctoral researchers to transition to independent researchers.

Jessica Cassin

August 2023

Bond Lab at Mount Sinai

Wishing the best of luck to Dr. Bond as she concludes her time with our lab and heads to Mount Sinai in May to start her own! Thank you for all of your hard work, Allison. We will miss you!


April 2023


American Association for the Advancement of Science

Congratulations to Dr. Guo-li Ming who has been elected as a 2022 American Association for the Advancement of Science (AAAS) Fellow, alongside seven other University of Pennsylvania faculty pictured below! Penn Today writes: Since 1874, AAAS, a scientific society aimed at advancing science, engineering, and innovation “throughout the world for the benefit of all,” has annually named a class of fellows. This year, the work spans 24 scientific disciplines. Access the full article here.


January 2023

More News!