Molecular Mechanisms Underlying Neuronal Development and Mental Disorders
Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.
As a newly established group at the University of Pennsylvania Perelman School of Medicine, we are looking forward to being a part of the community at Penn. At this time, we are seeking Postdoctoral Fellows and Graduate Students to join the lab. In addition, the lab is always looking for Undergraduate Students who are enthusiastic about stem cell and neuroscience research. Please contact us to inquire about opportunities within our lab.
Congrats to Ting Zhao and Yan Hong on their recent publication in the Journal of Molecular Cell Biology!
May 24, 2019
Publication Title: Loss of chromatin modulator Dpy30 compromises proliferation and differentiation of postnatal neural stem cells
Congrats to Qian et al. on their recent publication in Development on brain organoids!
April 16, 2019
Publication Title: Brain organoids: advances, applications and challenges
Summer Research Symposium
July 27, 2018
Summer research interns and rotating graduate students in the lab presented their summer projects in the lab's first Summer Research Symposium!