Ming Lab

Axon Regeneration

Epigenetic and epitranscriptomic regulation of axon regeneration

Axon regeneration in the adult central nervous system (CNS) is extremely limited because of the reduced intrinsic growth ability of mature neurons and an inhibitory environment that is not generally conducive to neuronal regeneration. In contrast, PNS neurons such as dorsal root ganglion cells (DRGs), exhibit relatively robust axon regeneration upon injury of the peripheral branches through a process involving de novo gene transcription and protein translation. Using a sciatic nerve crush injury mouse model, we are interested in understanding whether and how epigenetic and epitranscriptomic mechanisms are involved in regulating the regenerative state of DRGs after injury. We hope that the understanding of this endogenous form of regeneration may lead to the development of strategies to enhance CNS regeneration.

Selected Publications