Perelman School of Medicine at the University of Pennsylvania

Ming Lab

Organoid

Axon Regeneration

Epigenetic and epitranscriptomic regulation of axon regeneration

Axon regeneration in the adult central nervous system (CNS) is extremely limited because of the reduced intrinsic growth ability of mature neurons and an inhibitory environment that is not generally conducive to neuronal regeneration. In contrast, PNS neurons such as dorsal root ganglion cells (DRGs), exhibit relatively robust axon regeneration upon injury of the peripheral branches through a process involving de novo gene transcription and protein translation. Using a sciatic nerve crush injury mouse model, we are interested in understanding whether and how epigenetic and epitranscriptomic mechanisms are involved in regulating the regenerative state of DRGs after injury. We hope that the understanding of this endogenous form of regeneration may lead to the development of strategies to enhance CNS regeneration.


Selected Publications

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

Neuron

Weng YL, An R, Cassin J, Joesph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration Neuron. 2017; 94(2):337-346. PMID: 28426967.

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Epigenetic regulation of axonal regenerative capacity

Epigenomics

Weng YL, Joseph, J, An R, Song H, Ming GL. Epigenetic regulation of axonal regenerative capacity. Epigenomics. 2016; 8(10):1429-1442. PMID 27642866

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XTRPC1-dependent chemotropic guidance of neuronal growth cones

Nature Neuroscience

Shim, S., Goh, E.L., Ge, S., Sailor, K., Yuan, J.P., Roderick, H.L., Bootman, M.D., Worley, P.F., Song, H., Ming, G-l. (2005). XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci 8, 730-5. [PMC4005724]

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Adaptation in the chemotactic guidance of nerve growth cones

Nature

Ming, G-l.*, Wong, S.T., Henley, J., Yuan, X.B., Song, H.J., Spitzer, N.C., Poo, M.M.* (2002). Adaptation in the chemotactic guidance of nerve growth cones. Nature. 417, 411-8. (*: co-corresponding authors).

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Conversion of neuronal growth cone responses from repulsion to attraction

Science

Song, H-j*, Ming, G-l.*, He, Z.*, Tessier-Lavigne, M. and Poo, M-m.  (1998). Conversion of neuronal growth cone responses from repulsion to attraction. Science 281, 1515-8. (*: equal contribution).

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