Welcome!
The NeuroBridge Laboratory is a team of informaticians, engineers, neuroscientists, biostatisticians, clinical researchers, and practitioners at the Perelman School of Medicine, University of Pennsylvania. Our mission is to bridge the gap between brain science and clinical practice by developing computational and informatics methods that improve care for patients with neurological disorders. The lab is based in the Department of Biostatistics, Epidemiology and Informatics, with cross-departmental collaborations at Penn across Neurology, Neurosurgery, Radiology, Bioengineering, and Computer Science, as well as partnerships with the Children's Hospital of Philadelphia (CHOP) and institutions worldwide.
Our work spans three interconnected themes — methods, infrastructure, and clinical translation — organized around the following thrust areas:
- Discover. Novel methods to integrate multimodal clinical data — brain imaging, neurophysiology, and electronic health records — to identify biomarkers of disease severity, progression, and treatment response in individual patients.
- Develop. Scalable tools and cloud-based infrastructure for translational neuroscience, including a growing neural data ecosystem that aggregates high-quality multimodal data from multiple sites across the United States and internationally.
- Deploy. Clinical translation through rigorous validation — stratifying patients by complexity and disease subtype, benchmarking against standard-of-care, and laying the groundwork for multicenter federated clinical trials.
Our Vision