Perelman School of Medicine at the University of Pennsylvania

O'Rourke Lab

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Differentiated glioblastoma cells showing FGAP (green) and Tuj1 (red).

The O'Rourke Laboratory

Welcome to the O'Rourke Laboratory!  Located in Perelman South 8th Floor, alongside the Parker Institute for Cancer Immunotherapy, the O'Rourke lab is dedicated to advancing treatment options for glioblastoma.

Glioblastoma (GBM), glioma grade IV, is a devastating cancer with an annual incidence of 3.19/100,000 individuals per year (~10,000) and a median survival of 14.6 months following standard-of-care surgery, radiotherapy, and chemotherapy.  Few advances in treatment have been realized over the past 20 years, and 2-year survival remains close to 25%.  We are developing novel methods for treating GBM and improving the outcomes of patients with this devastating disease.  Our research focuses several areas of immuno-oncology, supported by model establishment and development.  Dr. O'Rourke's position in the University of Pennsylvania Brain and Spinal Cord Tumor Program provides our group with access to significant tumor tissue resources, providing a wide variety of GBM models for our research.