Perelman School of Medicine at the University of Pennsylvania

O'Rourke Lab

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Yibo Yin's Farewell and Holiday 2019 Lunch with almost the whole crew.

The O'Rourke Laboratory

Welcome to the O'Rourke Laboratory!  Located in Perelman South 8th Floor, alongside the Parker Institute for Cancer Immunotherapy, the O'Rourke Lab is dedicated to advancing treatment options for glioblastoma.

Glioblastoma (GBM), glioma grade IV, is a devastating cancer with an annual incidence of 3.19/100,000 individuals per year (~10,000) and a median survival of 14.6 months following standard-of-care surgery, radiotherapy, and chemotherapy.  Few advances in treatment have been realized over the past 20 years, and 2-year survival remains close to 25%.  We are developing novel methods for treating GBM and improving the outcomes of patients with this devastating disease.  Our research focuses several areas of immuno-oncology, supported by model establishment and development.  Dr. O'Rourke's position in the University of Pennsylvania Brain and Spinal Cord Tumor Program provides our group with access to significant tumor tissue resources, providing a wide variety of GBM models for our research.

We want to congratulate all of our summer fellowship awardees:

Thilan Tudor: 2020 Guggenheim Summer Research Fellow

Oliver Tang: 2020 NREF Medical Student Summer Research Fellow

Madeline Mandell: 2020 Penn Undergraduate Research Mentorship Program Fellow

Our clinical team has multiple ongoing clinical trials for GBM.  For clinical questions, please call 215-662-3487.

Post-Doctoral Research Position Available, Inquire below

The O'Rourke Lab has a Post-Doctoral Research Position Open.  If you are interested please contact Zev Binder by email:, or by phone: (215) 573-0837.