Recent publications from the Binder/O'Rourke Laboratory

Tudor T, Binder ZA, O'Rourke DM. CAR T Cells. Neurosurg Clin N Am. 2021 Apr;32(2):249-263. doi: 10.1016/j.nec.2020.12.005. Epub 2021 Feb 18. Review. PubMed PMID: 33781506.

Rathore S, Mohan S, Bakas S, Sako C, Badve C, Pati S, Singh A, Bounias D, Ngo P, Akbari H, Gastounioti A, Bergman M, Bilello M, Shinohara RT, Yushkevich P, O'Rourke DM, Sloan AE, Kontos D, Nasrallah MP, Barnholtz-Sloan JS, Davatzikos C. Multi-institutional noninvasive in vivo characterization of IDH, 1p/19q, and EGFRvIII in glioma using neuro-Cancer Imaging Phenomics Toolkit (neuro-CaPTk). Neurooncol Adv. 2020 Dec;2(Suppl 4):iv22-iv34. doi: 10.1093/noajnl/vdaa128. eCollection 2020 Dec. PubMed PMID: 33521638; PubMed Central PMCID: PMC7829474.

Bagley SJ, Till J, Abdalla A, Sangha HK, Yee SS, Freedman J, Black TA, Hussain J, Binder ZA, Brem S, Desai AS, O'Rourke DM, Long Q, Nabavizadeh SA, Carpenter EL. Association of plasma cell-free DNA with survival in patients with IDH wild-type glioblastoma. Neurooncol Adv. 2021 Jan-Dec;3(1):vdab011. doi: 10.1093/noajnl/vdab011. eCollection 2021 Jan-Dec. PubMed PMID: 33615225; PubMed Central PMCID: PMC7883768.

Tarrant JC, Binder ZA, Bugatti M, Vermi W, van den Oord J, Ranieri B, Assenmacher CA, Hoepp N, O'Rourke DM, Shan X, Danet-Desnoyers G, Radaelli E. Pathology of macrophage activation syndrome in humanized NSGS mice. Res Vet Sci. 2021 Jan;134:137-146. doi: 10.1016/j.rvsc.2020.12.003. Epub 2020 Dec 16. PubMed PMID: 33383491.

Singh N, Orlando E, Xu J, Xu J, Binder Z, Collins MA, O'Rourke DM, Melenhorst JJ. Mechanisms of resistance to CAR T cell therapies. Semin Cancer Biol. 2020 Oct;65:91-98. doi: 10.1016/j.semcancer.2019.12.002. Epub 2019 Dec 19. Review. PubMed PMID: 31866478; PubMed Central PMCID: PMC7684646.

Mallela AN, Agarwal P, Goel NJ, Durgin J, Jayaram M, O'Rourke DM, Brem S, Abdullah KG. An additive score optimized by a genetic learning algorithm predicts readmission risk after glioblastoma resection. J Clin Neurosci. 2020 Oct;80:1-5. doi: 10.1016/j.jocn.2020.07.048. Epub 2020 Aug 17. PubMed PMID: 33099328.

Nasrallah MLP, Desai A, O'Rourke DM, Surrey LF, Stein JM. A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features. Acta Neuropathol Commun. 2020 Jul 20;8(1):115. doi: 10.1186/s40478-020-00998-3. PubMed PMID: 32690110; PubMed Central PMCID: PMC7372861.

Davatzikos C, Barnholtz-Sloan JS, Bakas S, Colen R, Mahajan A, Quintero CB, Capellades Font J, Puig J, Jain R, Sloan AE, Badve C, Marcus DS, Seong Choi Y, Lee SK, Chang JH, Poisson LM, Griffith B, Dicker AP, Flanders AE, Booth TC, Rathore S, Akbari H, Sako C, Bilello M, Shukla G, Fathi Kazerooni A, Brem S, Lustig R, Mohan S, Bagley S, Nasrallah M, O'Rourke DM. AI-based prognostic imaging biomarkers for precision neuro-oncology: the ReSPOND consortium. Neuro Oncol. 2020 Jun 9;22(6):886-888. doi: 10.1093/neuonc/noaa045. PubMed PMID: 32152622; PubMed Central PMCID: PMC7283022.

Akbari H, Rathore S, Bakas S, Nasrallah MP, Shukla G, Mamourian E, Rozycki M, Bagley SJ, Rudie JD, Flanders AE, Dicker AP, Desai AS, O'Rourke DM, Brem S, Lustig R, Mohan S, Wolf RL, Bilello M, Martinez-Lage M, Davatzikos C. Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma. Cancer. 2020 Jun 1;126(11):2625-2636. doi: 10.1002/cncr.32790. Epub 2020 Mar 4. PubMed PMID: 32129893; PubMed Central PMCID: PMC7893811.

Kvint S, Ramchand P, Cox M, Sedora-Roman NI, Bagley L, O'Rourke DM, Hurst RW, Choudhri OA. Type V Dural Arteriovenous Fistula Supplied by the Artery of Wollschlaeger and Wollschlaeger Causing Cervical Myelopathy and Quadriparesis. World Neurosurg. 2020 May;137:55-61. doi: 10.1016/j.wneu.2020.01.122. Epub 2020 Jan 27. PubMed PMID: 32001402.

Bagley SJ, Desai AS, Nasrallah MP, O'Rourke DM. Immunotherapy and Response Assessment in Malignant Glioma: Neuro-oncology Perspective. Top Magn Reson Imaging. 2020 Apr;29(2):95-102. doi: 10.1097/RMR.0000000000000233. Review. PubMed PMID: 32271286.

Reardon DA, Desjardins A, Vredenburgh JJ, O'Rourke DM, Tran DD, Fink KL, Nabors LB, Li G, Bota DA, Lukas RV, Ashby LS, Duic JP, Mrugala MM, Cruickshank S, Vitale L, He Y, Green JA, Yellin MJ, Turner CD, Keler T, Davis TA, Sampson JH. Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial. Clin Cancer Res. 2020 Apr 1;26(7):1586-1594. doi: 10.1158/1078-0432.CCR-18-1140. Epub 2020 Feb 7. PubMed PMID: 32034072.

Henderson F Jr, Brem S, O'Rourke DM, Nasrallah M, Buch VP, Young AJ, Doot RK, Pantel A, Desai A, Bagley SJ, Nabavizadeh SA. ¹⁸F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling. Neurooncol Pract. 2020 Mar;7(2):152-157. doi: 10.1093/nop/npz068. Epub 2019 Dec 8. PubMed PMID: 32206320; PubMed Central PMCID: PMC7081387.

Fathi Kazerooni A, Akbari H, Shukla G, Badve C, Rudie JD, Sako C, Rathore S, Bakas S, Pati S, Singh A, Bergman M, Ha SM, Kontos D, Nasrallah M, Bagley SJ, Lustig RA, O'Rourke DM, Sloan AE, Barnholtz-Sloan JS, Mohan S, Bilello M, Davatzikos C. Cancer Imaging Phenomics via CaPTk: Multi-Institutional Prediction of Progression-Free Survival and Pattern of Recurrence in Glioblastoma. JCO Clin Cancer Inform. 2020 Mar;4:234-244. doi: 10.1200/CCI.19.00121. PubMed PMID: 32191542; PubMed Central PMCID: PMC7113126.

Nabavizadeh SA, Ware JB, Guiry S, Nasrallah MP, Mays JJ, Till JE, Hussain J, Abdalla A, Yee SS, Binder ZA, O'Rourke DM, Brem S, Desai AS, Wolf R, Carpenter EL, Bagley SJ. Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa016. doi: 10.1093/noajnl/vdaa016. Epub 2020 Feb 27. PubMed PMID: 32140683; PubMed Central PMCID: PMC7045782.

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Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O'Rourke DM, Brem S, Koumenis C, Gong Y, Fan Y. Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Sci Transl Med. 2020 Feb 26;12(532). doi: 10.1126/scitranslmed.aay7522. PubMed PMID: 32102932; PubMed Central PMCID: PMC7261487.

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Salinas RD, Durgin JS, O'Rourke DM. Potential of Glioblastoma-Targeted Chimeric Antigen Receptor (CAR) T-Cell Therapy. CNS Drugs. 2020 Feb;34(2):127-145. doi: 10.1007/s40263-019-00687-3. Review. PubMed PMID: 31916100.

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Bagley SJ, Nabavizadeh SA, Mays JJ, Till JE, Ware JB, Levy S, Sarchiapone W, Hussain J, Prior T, Guiry S, Christensen T, Yee SS, Nasrallah MP, Morrissette JJD, Binder ZA, O'Rourke DM, Cucchiara AJ, Brem S, Desai AS, Carpenter EL. Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study. Clin Cancer Res. 2020 Jan 15;26(2):397-407. doi: 10.1158/1078-0432.CCR-19-2533. Epub 2019 Oct 30. PubMed PMID: 31666247; PubMed Central PMCID: PMC6980766.

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Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H. A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2020 Jan 9;180(1):188-204.e22. doi: 10.1016/j.cell.2019.11.036. Epub 2019 Dec 26. PubMed PMID: 31883794; PubMed Central PMCID: PMC7556703.

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Bagley SJ, O'Rourke DM. Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions. Pharmacol Ther. 2020 Jan;205:107419. doi: 10.1016/j.pharmthera.2019.107419. Epub 2019 Oct 16. Review. PubMed PMID: 31629009.

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Rathore S, Akbari H, Bakas S, Pisapia JM, Shukla G, Rudie JD, Da X, Davuluri RV, Dahmane N, O'Rourke DM, Davatzikos C. Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients. Front Comput Neurosci. 2019;13:81. doi: 10.3389/fncom.2019.00081. eCollection 2019. PubMed PMID: 31920606; PubMed Central PMCID: PMC6923885.