Assistant Professor, Vertebrate Physiology, Eastern Washington University

Education

 

2002-2006

BS, Cellular and Molecular Biology, Tulane University, New Orleans, LA

2006-2011

 

PhD, Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL

2015-present

Penn-PORT fellow, Orthopaedic Surgery, University of Pennsylvania

 

  • Research mentor: Jaimo Ahn, MD, PhD; University of Pennsylvania

  • Teaching mentor: Susan Safford, PhD; Lincoln University

Research Topic: Bone cell biology

My research interests focus primarily on understanding the cellular and molecular mechanisms of the skeleton and to improve skeletal health through that knowledge. Understanding of fundamental mechanisms governing bone physiology is an essential foundation for their therapeutic exploitation. Failure of the mechanisms of bone homeostasis can result in bone loss, increased risk of fractures, and overall reduction in quality of life. Likewise, insufficiency in bone repair and remodeling can result in poor healing and loss of function when fractures occur. Both situations are of great clinical concern especially as the aged population increases. Towards addressing these important clinical challenges, I have dedicated myself to the investigation of molecular mechanisms of osteoclast differentiation and function, and I seek to pursue my work as an independent academic investigator. My goal is to understand the cell-autonomous and osteoblast-coupling functions of the osteoclast in order to develop therapies and interventions to improve human bone health.

 

 
Publications

Journal Publications 

  • Sasanka Ramanadham, Tomader Ali, Jason W Ashley, Robert N Bone, William D Hancock, Xiaoyong Lei; “Calcium-Independent Phospholipases A2 (iPLA2s) and their Roles in Biological Processes and Diseases,” Journal of Lipid Research. 2015 Sep;56(9):1643-68. doi: 10.1194/jlr.R058701. Epub 2015 May 28.

  • Jason W Ashley, Jaimo Ahn, Kurt D Hankenson; “Notch Signaling Promotes Osteoclast Maturation and Resorptive Activity,” Journal of Cellular Biochemistry. 2015 Nov;116(11):2598-609. doi: 10.1002/jcb.25205.

  • Paulina Wyrozumska, Jason W Ashley, Sasanka Ramanadham, Qinglan Liu, W Timothy Garvey, Elizabeth Sztul; “Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription,” Cellular Logistics. 2014 Jan 1;4(1):e27732. Epub 2014 Jan 9. 

  • James J Cody, Angel A Rivera, Gray R Lyons, Sherry W Yang, Ming Wang, Jason W Ashley, Sreelatha Meleth, Xu Feng, Gene P Siegal, Joanne T Douglas; “Expression of Osteoprotegerin from a Replicating Adenovirus Inhibits the Progression of Prostate Cancer Bone Metastases in a Murine Model;” Laboratory Investigations; 2013 Mar;93(3):268-78 Epub 2013 Jan 28 

  • Takashi Izawa, Wei Zou, Jean C Chappel, Jason W Ashley, Xu Feng, Steven L Teitelbaum; “c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton;” Molecular and Cellular Biology; 2012 Jul;32(14):2943-53. Epub 2012 May 21 

  • Joel Jules, Ping Zhang, Jason W Ashley, Shi Wei, Zhenqi Shi, Jiangzhong Liu, Suzanne M Michalek, Xu Feng; “Molecular basis of the requirement of RANK signaling for interleukin-1 (IL-1)-mediated osteoclastogenesis;” Journal of Biological Chemistry; 2012 May 4;287(19):15728-38 Epub 2012 Mar 13 

  • Jason W Ashley, Zhenqi Shi, Haibo Zhao, Xingsheng Li, Robert A Kesterson, Xu Feng; “Genetic Ablation of CD68 Results in Mice with Increased Bone and Dysfunctional Osteoclasts;” PLoS One. 2011;6(10):e25838 Epub 2011 Oct 3 

  • Jason W Ashley, Erin M McCoy, Daniel A Clements, Zhenqi Shi, Taosheng Chen, Xu Feng; “Development of Cell-Based High-Throughput Assays for the Identification of Inhibitors of Receptor Activator of Nuclear Factor-Kappa B Signaling;” Assay and Drug Development Technologies; 2011 Feb;9(1):40-9 Epub 2010 Nov 4 

  • Joel Jules, Jason W Ashley, Xu Feng; “Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis;” Expert Opinion on Therapeutic Targets; 2010 Sep;14(9):923-34 

Book Chapters 

  • Xu Feng & Jason W Ashley, “Metabolic Bone Disease II,” pp. 829-837, Pathobiology of Human Disease, ISBN: 978-0-12-386457-4 

  • Jing Zou & Jason W Ashley, “Fluorosis,” pp. 893-898, Pathobiology of Human Disease, ISBN: 978-0-12-386457-4 

Contact Info:

Jason W. Ashley, Ph.D.
Postdoctoral Fellow
Department of Orthopaedic Surgery
Perelman School of Medicine
University of Pennsylvania
Philadelphia VA Medical Center
Research Building 21
3900 Woodland Ave
Philadelphia, PA 19104  

E-mail: jasonash@upenn.edu