Determinants of Systemic Immune Reactivation in ANCA Associated Vasculitis (DORA)

The purpose of the study is to understand the community of bacteria and other microbes that reside in the nose as well as the genetic changes in the nasal tissue in people with AAV, and how these relate to the overall immune response in the blood of people with AAV.

NO. You will not take experimental drugs in this study.

The objective of the study is to examine the changes in the nasal microbiome and the immune response to understand the cause of these diseases and develop better tests and therapies.

There are many factors that determine if you are eligible. Some requirements include:

Patients must first have a diagnosis of the following types of vasculitis:

• Granulomatosis with polyangiitis (GPA // Wegener's)
• Microscopic polyangiitis (MPA)
• Eosinophilic granulomatosis with polyangiitis (EGPA // Churg-Strauss)

Participants will be enrolled in the study for approximately 2 years.

Research procedures will occur approximately every 3 months. Nasal, blood, questionnaires, and urine collection will occur in the first year only. During the second year, only questionnaires will be collected.

Thank you for your interest! If you wish to learn more, please contact:

Rui Liang

rheumatologyresearch@pennmedicine.upenn.edu

215-614-4417