Tissue Engineering Approaches for Tumor Immunotherapy
To develop tissue on a chip as models of human tumors and tumor-immune interactions.
Goals:
- Establish simple model of human tumor cells growing in tissue microenvironment on a chip (lung/NSCLC, Skin/melanoma, etc)
- Test ability to add in lymphocytes and/or myeloid cells
- Develop methods to monitor and evaluate immune cells on chip and extracted from chip
Accomplishments:
- Developing experimental techniques to maintain patient-derived tumor explants in vitro.
- Engineering a co-culture platform that allows vascularized and perfusable tumor tissues. Tumor spheroids made out of dissociated lung cancer cells.
Project Participants: John Wherry, Dan Huh, Nicole Lu (PICI@Penn Directory)