2018 Annual Retreat & Symposium | November 12, 2018 | Learn More

Upcoming Events

Recent News

  • Read about Dr. Hansell Stedman’s and Leon Morales’s (PMI trainee) efforts to engage a young man with Duchenne Muscular Dystrophy (DMD) in participating in their scientific DMD research HERE

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  • PMI Annual Retreat and Symposium is
    Nov. 12. Details HERE and Register HERE

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  • Drs. Ben Prosser and Ken Margulies identify a new target for treating heart failure. See Nature Medicine paper HERE and Penn press release HERE

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  • See Jeff Nirschl’s new investigation that uses deep-learning to identify heart failure from endomyocardial biopsy HERE

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  • Dr. Rebecca Wells’s research team describes the structure and distribution of an unrecognized interstitium in human tissues. See press release HERE and research article HERE

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  • PMI Director, Michael Ostap and Yale's Charles Sindelar used the Nobel Prize-winning method of cryo-electron microscopy to visualize how myosins change shape to power contraction, adapt for fast and slow activities, and “feel” mechanical forces that change their activity. See article in PNAS HERE

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  • Janmey and Wells Labs design novel biomimetic matrices for cell growth. See paper HERE

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  • Ostap and Holzbaur Labs engineer cytoskeletal networks to investigate membrane trafficking and deformation. See paper HERE

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  • Prof. Wei Guo and colleagues solve the high-resolution structure of the exocyst complex. See details HERE

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  • Kashina Lab proposes a "silent code" mechanism for control of the functional diversity of protein isoforms. See Penn News Highlight HERE

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  • The Goldman’s lab new work is featured on the cover of the biophysical journal. See article HERE

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  • Thanks to all who participated in the 2017 PMI Retreat and Symposium. Learn more HERE

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  • The Journal of Cell Science has listed PMI Member Melike Lakadamyali as a Cell Scientist to watch. See the press release HERE

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  • Congratulations to Yale E. Goldman, MD, PhD on being elected to National Academy of Science. See details HERE

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  • Congratulations to Prof. Clara Franzini-Armstrong for being named a 2017 Honorary Degree Recipient! This is one of the University of Pennsylvania’s highest honors. See details HERE

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  • Congratulations to Ben Prosser for receiving the 2017 Linda Pechenik Montague Investigator Award!DETAILS HERE>

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  • Congratulations to Betsy McIntosh (Ostap/Holzbaur Labs) for receiving her PhD after successfully defending her thesis!

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  • See Press Release about Penn’s newly created Center for Engineering Mechanobiology, headed by Profs. Yale E. Goldman and Vivek Shenoy, HERE

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  • Listen to Dr. Erika Holzbaur interviewed on NPR regarding Nobel Prize awarded to Dr. Yoshinori Ohsumi for autophagy HERE

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  • Congratulations to Yale Goldman, Vivek Shenoy, Rebecca Wells and colleagues for being awarded NSF funds to launch the STC Center for Engineering MechanoBiology. See NSF press release HERE

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  • Read Press Release about the work from the Khurana and Baur Labs describing the consequences of NAD deficiency on muscle function. HERE

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  • The Goldman Lab finds that a powerstroke within the ribosome is required for translocation in protein synthesis. See PNAS paper here

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  • The Prosser Lab finds a key mechanical role for microtubules in health and disease. See Penn press release and Science article here

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  • Congratulations to Prof. Erika Holzbaur for winning the Jane M. Glick Graduate Student Teaching Award! This award recognizes excellence in teaching and mentorship in Penn’s Biomedical Graduate Studies program.

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  • Thanks to all who participated in the PMI Retreat and Symposium. Learn more

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  • Biophysical Journal Cover highlights work from the Grishchuk Lab. See article HERE and cover image HERE

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  • Dr. David Kast has been chosen to present his research at the “Future of Biophysics Symposium” at the 2016 Biophysical Society Meeting in Los Angeles. See details here.

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  • Congratulations to Erika Holzbaur for being awarded the 2015 Stanley N. Cohen Biomedical Research Award from the Perelman School of Medicine! This elite award recognizes research excellence in the basic sciences at Penn.

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  • Congratulations to Drs. Prosser, Discher, and Liu for receiving the 2015 Kaufman Foundation Initiative Award. See details here.

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  • Congratulations to Dr. Yale E. Goldman for winning the Biophysical Society’s Distinguished Service Award. Details here.

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  • Our sincere thanks to Drs. Ekaterina Grishchuk and Ben Prosser for organizing an outstanding 2014/15 PMI seminar series HERE. Stay tuned for the 2015/16 schedule being organized by Drs. Anna Kashina and Mike Ostap.

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  • The Kashina Lab discovers a novel protein modification that regulates purine nucleotide biosynthesis. See paper HERE and Penn press release HERE

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  • Please see the tribute to the incredible career of our PMI colleague, Prof. Howard Holtzer written by Drs. Stockdale, Sanger and EmersonHERE

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  • Congratulations to Erika Holzbaur for being selected as the recipient of the American Neurological Association’s 2015 F.E. Bennett Memorial Lectureship Award. This award was established in 1979 by Dr. Abram Elting Bennett in memory of his son Foster E. Bennett, MD, and is presented annually to an outstanding researcher and educator in neurology

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  • The Dominguez Lab finds protein "Comet Tails” that propel a cell recycling process. See Penn press releaseHERE and
    and the Current Biology paper HERE

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  • The Lampson and Black Labs identify key protein-DNA interactions important for chromosome inheritance. Read the Science paper HERE

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  • The Sweeney Lab characterizes a key step important for force generation in myosins. Read the Developmental Cell paper HERE

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  • The Grishchuk Lab and colleagues discover the “tubulin code” for chromosome movement during mitosis. See details HERE

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  • Congratulations to Meredith Wilson of the Holzbaur Lab who is a CAMB winner of the 2015 Saul Winegrad Award for Outstanding Dissertation!

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  • Congratulations to Janelle Spinazzola (Barton/Sweeney Labs) for receiving her PhD after successfully defending her thesis! Janelle has been a trainee on the PMI T32 Training Grant.

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  • Congratulations to Jeff Nirschl (Holzbaur Lab) for being awarded a prestigious F30 fellowship from NINDS/NIH!

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  • Janelle Spinazzola (PMI T32 trainee) in Elisabeth Barton’s Lab uncovers a key mechanosensing molecule in the dystrophin complex. Details can be found HERE

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  • Students and Post-Docs: Apply for the Annemarie Weber Prize for Research Presentation and Participation. Deadline February 2. HERE

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  • Images from PMI scientists featured at Philadelphia International Airport art exhibit. See details and slide show HERE

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  • The Bi and Svitkina Labs obtain an unparalleled view of septin structures within cells and define septin remodelling dynamics during the cell cycle. DETAILS

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  • The Lindstrom Lab demonstrates efficacy for vaccine for myasthenia gravis. See press release HERE

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  • Dr. Ekaterina Grishchuk is the 2014 recipient of Michael S. Brown New Investigator Research Award. Congratulations Katya!

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  • Please read the Penn Medicine press release regarding the Pennsylvania Muscle Institute's NIH PO1 HERE

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  • Congratulations to the PMI team of Ostap, Dominguez, Goldman, Holzbaur, and Shuman for receiving a renewal of their NIH PO1!

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  • Congratulations to Ryan Jamiolkowski (Goldman Lab) for receiving a Ruth L. Kirschstein Award (F30) from NIH.

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  • The Dominguez Lab determines how actin filaments are capped in muscle fibers. See Article in Science HERE

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  • Sandra Maday in the Holzbaur Lab resolves crucial steps in autophagosome biogenesis. HERE

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  • Congratulations to Michael Greenberg (Ostap Lab) for receiving a prestigious Pathway to Independence Award (K99/R00) award from NIH/NHLBI.

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  • Meredith Wilson (Holzbaur Lab) wins award for best poster by a graduate student at the Gordon Research Conference on Muscle & Molecular Motors. This prestigious award was sponsored by the Lymn Foundation HERE Meredith is a former PMI T32 trainee.

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Recent Publications



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The PMI is prominent in technological and methodological development, especially in advanced light microscopy, structural spectroscopy, force spectroscopy, nanotechnology, and biochemical kinetics. Additionally, the PMI offers unique muscle assessment technologies to our members. To learn more about our facilities and services, please click below.

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