PMI membership consists of an extraordinarily strong interdisciplinary team of scientists that investigate muscle biology and non-muscle contractile systems. Specifically, our members use biophysics, biochemistry, genetics, physiology and ultrastructure to understand cell migration and intracellular transport, molecular motors, cell division, muscle contraction and development, muscle pathologies and therapies targeted to muscle disease. Faculty interested in joining may contact pmireply@pennmedicine.upenn.edu with their CV and a brief research description.
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Director, Pennsylvania Muscle Institute (PMI); Microtubule-based molecular motors
Phospholipid Signaling in Platelet and T-cells
Cardiovascular Metabolism
Metabolic and signaling pathways by which nutrient intake can influence longevity, with a particular emphasis on NAD and mTOR
Professor Emeritus, E-C coupling in skeletal muscle
Mechanisms of Cell Polarization, Cytokinesis, and Septin Assembly and Function
Mechanobiology of development and regeneration
Interpret genetic variation and combat global health threats by understanding/exploiting protein dynamics using a combination of biophysical experiments.
Role of the cytoskeleton in T cell function
In situ structural biology, cryo-electron tomography
G-Protein & cell transformations
Mechanical response of cells to applied mechanical stress
Engineering innervated skeletal and cardiac muscle systems; neuromuscular regeneration; proprioceptive feedback; reflex circuits; bioelectronic interfaces; tissue biomechanics.
Hypertrophic cardiomyopathy (HCM)
Cell and molecular mechanics
Structural Biology and Biochemistry, the Cytoskeleton and the Link Between the Cytoskeleton, Membranes and Signaling
Clinician scientist studying genetic muscle disorders with expertise in human genetics, disease modelling, pathomechanism studies, and therapy development.
Cell fate mapping, mechanobiology, and tissue engineering of connective tissues
Structural and Functional Drivers of Right Ventricular Faliure
