Welcome to Day Lab

The Day lab is interested in genetic heart muscle diseases. Our research program integrates translational and clinical science, with a primary focus on hypertrophic cardiomyopathy. We want to understand the full spectrum of disease evolution and progression, from the primary effects of sarcomere gene mutations in cardiac muscle cells to the phenotypic expression and predictors of adverse outcomes in patients.

Research News

Congratulations to Jonathan on his thesis defense!  Well done, Dr. Herrera!

Congratulations to Marcus on being awarded the American Physiology Society’s (APS) Preparing Effective Physiology Educators (PrEP-E) fellowship!  Marcus will take part in pedagogy seminars and attend the Institute on Training and Learning conference in Madison, Wisconsin the summer of 2022.

Congratulations to David Hsu!  He was accepted into the Master of Science in Translational Research (MSTR) degree program!

Congratulations to Graham Branscom for receiving a place in the University Scholars (UScholars) program!

Congratulations to Andrea Thompson for getting a great score on her K08!

Congratulations to Sharlene Day for receiving the 2021 Sarnoff Cardiovascular Research Foundation Spirit Award!

Congratulations Jonathan Herrera for presenting an abstract at the American Heart Association Scientific Sessions entitled: “High Intensity Exercise Increases Cardiorespiratory Capacity in a Preclinical Hypertrophic Cardiomyopathy Mouse Model."

Welcome to new postdoctoral fellow Marcus Wagner and congratulations on being awarded a spot on the Penn Muscle Institute T32 training grant!

Dr. Day talks about her current research and work as a physician scientist in Penn Medicine News.

Graham Branscom has been accepted to the PURM summer fellowship.  Congrats, Graham!

Congratulations to Andrea Thompson for her recent paper accepted to Genetics in MedicineThompson AD, Helms AS, Kannan A, Yob U, Lakdawala NK, Wittekind SG, Pereira AC, Jacoby DL, Colan SD, Ashley EA, Saberi S, Ware JS, Ingles J, Semsarian C, Michels M, Mazzarotto F, Olivotto I, Ho CY, Day SMComputational Prediction of Protein Subdomain Stability as a Novel Approach to MYBPC3 Variant Interpretation and Clinical Risk Stratification in Hypertrophic Cardiomyopathy, Genetics in Medicine

Jonathan Herrera's publication in JCI Insight: Herrera J, Louzon S, Pifer K, Leannder D, Merrihew G, Park JH, Szczesniak K, Whitson J, Wilkinson JE, Fiehn O, MacCoss MJ, Day SM, Miller RA, Garratt M. Acarbose has pronounced sex dependent and independent effects on age-related physical function, cardiac health and lipid biology.

Read Ishwari Nagnur's article assessing how gender stereotypes hold girls back from STEM careers. 

Congrats to Jonathan Herrera for receiving a research training grant from the American Physiological Society

Congrats to David Hsu for receiving a summer research fellowship from the Institute for Translational Medicine and Therapeutics at Penn Medicine

Congrats to Adam Helms, Andrea Thompson, Jaime Yob, and other authors for their new manuscript in Circulation: Genomics and Precision Medicine, Spatial and Functional Distribution of MYBPC3 Pathogenic Variants and Clinical Outcomes in Patients with Hypertrophic Cardiomyopathy

Congrats to Andrea Thompson and Jonathan Herrera for their platform presentations at the Keystone Symposia in Keystone, CO.     

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