Welcome to Day Lab
The Day lab is interested in genetic heart muscle diseases. Our research program integrates translational and clinical science, with a primary focus on hypertrophic cardiomyopathy. We want to understand the full spectrum of disease evolution and progression, from the primary effects of sarcomere gene mutations in cardiac muscle cells to the phenotypic expression and predictors of adverse outcomes in patients.
Dr. Day talks about her current research and work as a physician scientist in Penn Medicine News.
Graham Branscom has been accepted to the PURM summer fellowship. Congrats, Graham!
Andrea Thompson for her recent paper accepted to Genetics in Medicine! Thompson AD, Helms AS, Kannan A, Yob U, Lakdawala NK, Wittekind SG, Pereira AC, Jacoby DL, Colan SD, Ashley EA, Saberi S, Ware JS, Ingles J, Semsarian C, Michels M, Mazzarotto F, Olivotto I, Ho CY, Day SM. Computational Prediction of Protein Subdomain Stability as a Novel Approach to MYBPC3 Variant Interpretation and Clinical Risk Stratification in Hypertrophic Cardiomyopathy, Genetics in Medicine.
Jonathan Herrera for his publication in JCI Insight: Herrera J, Louzon S, Pifer K, Leannder D, Merrihew G, Park JH, Szczesniak K, Whitson J, Wilkinson JE, Fiehn O, MacCoss MJ, Day SM, Miller RA, Garratt M. Acarbose has pronounced sex dependent and independent effects on age-related physical function, cardiac health and lipid biology.
Student Ishwari Nagnur for her article assessing how gender stereotypes hold girls back from STEM careers.
Jonathan Herrera for receiving a research training grant from the American Physiological Society
David Hsu for receiving a summer research fellowship from the Institute for Translational Medicine and Therapeutics at Penn Medicine
Adam Helms, Andrea Thompson, Jaime Yob, and other authors for their new manuscript in Circulation: Genomics and Precision Medicine, Spatial and Functional Distribution of MYBPC3 Pathogenic Variants and Clinical Outcomes in Patients with Hypertrophic Cardiomyopathy.
Andrea Thompson and Jonathan Herrera for their platform presentations at the Keystone Symposia in Keystone, CO.