Publications

Selected Publications:

A full list of publications can be found on PubMed.  

  1.  Thompson AD, Wagner MJ, Rodriguez J, Malhotra A, Roest SV, Lilienthal U, Shao H, Yob JM, Prosser BL, Helms AS, Gestwicki JE, Ginsburg D, Day SM. : An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.  JACC BTS;  in press

  2. Vissing CR, Axelsson AR, Day SM, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossion R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossaano JW, Owens AT, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Bundgaard H, Orav J, Ho CY: Cardiac Remodeling in Subclinical Hypertrophic Cardiomyopathy - Insights from the VANISH Randomized Clinical Trial.  JAMA Cardiology September 2023 Notes: doi:10.1001/jamacardio.2023.2808

  3. Alaiwi SA, Roston TM, Marstrand P, Claggett BL, Parikh VN, Helms AS, Ingles J, Lampert R. Lakdawara NK, Michels M, Owens AT, Rossano JW, Saberi S, Abrams DJ, Ashley EA, Semsarian C, Stendahl JC, Ware JS, Miller E. Ryan TD, Russell MW, Day SM, Olivotto I, Vissing CR, Ho CY. : Left Ventricular Systolic Dysfunction in Patients Diagnosed with Hypertrophic Cardiomyopathy During Childhood: Insights from the SHaRe Registry.  Circulation 148(5): 394-404, August 2023

  4. Moulson N, Petek BJ, Ackerman NJ, Churchill TW, Day SM, Kim JH, LKliethermes SA, Lampert R, Levine BD, Martinez MW, Patel MR, Phelan D, Harmon KG, Baggish AL, Drezner JA. : Rationale and Design of the ORCCA (Outcomes Registry for Cardiac Conditions in Athletes) Study. Journ Amer Heart Assoc 12(11): e029052, June 2023

  5. Lampert R, Ackerman MJ, Marino BS, Burg M, Ainsworth B, Salberg L, Tome Esteban M, Ho CY, Abraham R, Balaji S, Barth C, Berul C, Bos M, Cannom D, Choudhury L, Concannon M, Cooper R, Czosek RJ, Dubin AM, Dziura J, Eidem B, Emery MS, Estes M, Etheridge SP, Geske JB, Gray B, Hall K, Harmon KG, James CA, Lal AK, Law IH, Li F, Link MS, McKenna WJ, Molossi S, Olshansky B, Ommen SR, Saarel EV, Saberi S, Simone L, Tomaselli G, Ware JS, Zipes DP, Day SM, for the LIVE Consortium: Vigorous Exercise in Patients with Hypertrophic Cardiomyopathy. JAMA Cardiology 8(6): 595-605, June 2023

  6. Kim Y. Mastali M, Van Eyk JE, Orav EJ, Vissing SR, Day SM, Axelsson RA, Russell MW, Zahka K, Lever HM, Pereira AC, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Byundgaard H, benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Soslow JH, Becker JR, Seidman CE, Ho CY. VANISH Investigators: Transforming Growth Factor-Beta Analysis of the VANISH Trial Cohort. Circ Heart Failure 16(4): e010314, April 2023

  7. Herrera JJ, Pifer K, Louzon S, Leander D, Fiehn O, Day SM, Miller RA, Garratt M: Early or Late-life treatment with acarbose or rapamycin improves physical performance and affects cardiac structure in aging mice.  J Gerontology A Biol Sci Med Sci 78(3): 397-406, March 2023

  8. Levin M, Tsao N, Singhal P, Liu C, Vy HM, Paranjpe I, Backman J, Bellomo T, Bone W, Biddinger K, Hui Q, Dikilitas O, Satterfield B, Yang Y, Morley M, Bradford, Y, Burke M, Reza N, Charest B, Regeneron Genetic Center Consortium, Judy R, Puckelwartz M, Hakonarson H, Khan A, Kottyan L, Kullo I, Luo Y, McNally E, Rasmussen-Torvik L, Day SM, Do R, Phillips L, Ellinor P, Nadkarni G, Ritchie M, Arany Z, Cappola T, Margulies K, Aragam K, Haggerty C, Joseph J, Sun Y, Voight B, Damrauer S: Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.  Nat Comm 13(1): 6914, November 2022

  9. Gimeno JR, Olivotto I, Rodríguez AI, Ho CY, Fernández A, Quiroga A, Espinosa MA, Gómez-González C, Robledo M, Tojal-Sierra L, Day SM, Owens A, Barriales-Villa R, Larrañaga JM, Rodríguez-Palomares J, González-Del-Hoyo M, Piqueras-Flores J, Reza N, Chumakova O, Ashley EA, Parikh V, Wheeler M, Jacoby D, Pereira AC, Saberi S, Helms AS, Villacorta E, Gallego-Delgado M, de Castro D, Domínguez F, Ripoll-Vera T, Zorio-Grima E, Sánchez-Martínez JC, García-Álvarez A, Arbelo E, Mogollón MV, Fuentes-Cañamero ME, Grande E, Peña C, Monserrat L, Lakdawala NK; Dilema International Cardiomyopathy and Heart Failure Registry and international SHaRe (Sarcomeric Human Cardiomyopathy Registry) Investigators group.: Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry. ESC Heart Failure 9(4): 2189-2198, August 2022

  10. Guo AH, Baliira R, Skinner ME, Kumar S, Andren A, Zhang L, Goldsmith RS, Michan S, Davis NJ, Maccani MW, Day SM, Sinclair DA, Brody MJ, Lyssiotis CA, Stein AB, Lombard DB: Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload. Sci Reports 12(1): 12258, July 2022

  11. Previs MJ, O'Leary TS, Morley MP, Palmer B, LeWinter M, Yob J, Pagani FD, Petucci C, Kim MS, Margulies KB, Arany Z, Delly DP, Day SM: Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy. Circulation HF 15(6): e009521, May 2022

  12. Park J, Packard EA, Levin MG, Judy RL, Regeneron Genetics Center, Damrauer SM, Day SM, Ritchie MD, Rader DJ. : A Genome First Approach to Rare Variants in Hypertrophic Cardiomyopathy Genes MYBPC3 and MYH7 in a medical biobank. Hum Mol Genetics 31(5): 827-837, March 2022

  13. Norrish G, Qu C, Field E. Cervi E, Khraiche D. Klaassen S, Ojala TH, Sinagra G, Yamazawa H, Marrone C, Popoiu A, Centeno F. Schouvey S, Olivotto I, Day SM, Colan S, Rossano J, Wittekind SG, Saberi S, Russell M, Helms A, Ingles J, Semsarain C, Elliott PM, Ho CY, Omar RZ, Kaski JP: External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy. Eur J Prev Cardiol  29(4): 678-686, March 2022

  14. Sahu I, Mali SM, Sulkshane P, Rozenberg A, Xu C, Morag R, Sahoo MP, Singh SK, Ding Z, Wang Y, Day SM, Cong Y, Kleifeld O, Brik A, Glickman MH: The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature Communications 12: 6173, Oct 2021.

  15. Ho CY, Day SM, Axelsson A, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RGB, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MR, Patel AR, Wilmot I, Thrush P, Vargas JD, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, Burns KM, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E. Valsartan in Early Stage Hypertrophic Cardiomyopathy: A Randomized Phase 2 Trial. Nature Medicine 2021, doi.org/10.1038/s41591-021-01505-4

  16. Park J, Packard EA, Levin MG, Judy RL, Regeneron Genetics Center, Damrauer SM, Day SM, Ritchie MD, Rader DJ. A Genome First Approach to Rare Variants in Hypertrophic Cardiomyopathy Genes MYBPC3 and MYH7 in a medical biobank. Hum Mol Genetics 2021 Sept 20. Doi:10.1093/hmg/ddab249

  17. Owens A, Day SM. Reappraising Genes for Dilated Cardiomyopathy – Stepping Back to Move Forward. Circulation 2021 Jul 6;144(1):20-22

  18. Limongelli G, Monda E, D’Aponte A, Caiazza M, Rubino M, Espositio A, Palmiero G, Moscarella E, Messina G, Calabro P, Scudiero O, Pacileo G, Monda M, Bossone E, Day SM, Olivotto I.  Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy. Heart Fail Clinics. 2021 Apr;17(2):303-313.

  19. Marston NA, Han L, Olivotto I, Day SM, Ashley EA, Michels M, Pereira AC, Ingles J, Semsarian C, Jacoby D, Colan SD, Rossano JW, Wittekind SG, Ware JS, Saberi S, Helms AS, Ho CY. Clinical Characteristics and Outcomes of Childhood-Onset Hypertrophic Cardiomyopathy. European Heart Journal 2021 May 21, 42 (20):ehab148. doi: 10.1093/eurheartj/ehab148

  20. Puckelwartz MJ, Pesce LL, Dellefave-Castillo LM, Wheeler MT, Pottinger TD, Robinson AC, Kearns SD, Gacitga AM, Schoppen ZJ, Pan W, Kim G, Wilcox JE, Anderson AS, Ashley EA, Day SM, Cappola T, Dorn GW, McNally EM. Genomic Context Differs Between Human Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy. Journal of the American Heart Association 2021 Mar 25:e019944. doi: 10.1161/JAHA.120.019944

  21. Thompson AD, Helms AS, Kannan A, Yob U, Lakdawalla NK, Wittekind SG, Pereira AC, Jacoby DL, Colan SD, Ashley EA, Saberi S, Ware JS, Ingles J, Semsarian C, Michels M, Mazzarotto F, Olivotto I, Ho CY, Day SM. Computational prediction of protein subdomain stability as a novel approach to MYBPC3 variant interpretation and clinical risk stratification in hypertrophic cardiomyopathy. Genetics in Medicine. March 29, 2021.  

  22.  Lakdawalla N, Olivotto I, Day SM, Han L, Ashley EA, Michels M, Ingles J, Semsarian C, Jacoby J, Jefferies JL, Colan SD, Pereira AC, Rossano JW, Wittekind S, Ware JS, Saberi S, Helms AS, Cirino AL, Leinwand LA, Seidman CE, Ho CY. Associations between female sex, sarcomere variants and clinical outcomes in hypertrophic cardiomyopathy, Circulation: Genomics and Precision Medicine 2020 Dec 7. Doi: 10.1161/CIRCGEN 120.003062

  23. Canepa M, Fumagalli C, Tini G, Vincent Tompkins J, Day SM, Ashley EA, Mazzarotto F, Ware JS, Michels M, Jacoby D, Ho CY, Olivotto I. Temporal trend of age at diagnosis in hypertrophic cardiomyopathy: an analysis of the international SHaRe Registry, Circulation: Heart Failure 2020, doi:10.1161/CIRCHEARTFAILURE.120.007230

  24. Herrera J, Louzon S, Pifer K, Leannder D, Merrihew G, Park JH, Szczesniak K, Whitson J, Wilkinson JE, Fiehn O, MacCoss MJ, Day SM, Miller RA, Garratt M. Acarbose has pronounced sex dependent and independent effects on age-related physical function, cardiac health and lipid biology, JCI Insight, September 2020.

  25. Helms AS, Thompson AD, Glazier AA, Hafeez H, Kabani S, Rodriguez J, Yob JM. Woolcock H, Lakdawal HK, Wittekind WG, Pereira AC, Jacoby DL, Colan SD, Ashley EA, Saberi S, Ware JS, Ingles J, Semsarian C, Michels M, Olivotto I, Ho CY, Day SM. Spatial and Functional Distribution of MYBPC3 Pathogenic Variants and Clinical Outcomes in Patients with Hypertrophic Cardiomyopathy. Circulation: Genomics and Precision Medicine 2020, doi: 10.1161/CIRCGEN.120.002929

  26. Musunuru K, Hershberger RE, Day SM, Klinedinst J, Landstrom A, Parikh VN, Prakash S, Semsarian C, Sturm AC. Genetic Testing for Inherited Cardiovascular Diseases. Circulation: Genomic and Precision Medicine 2020 Jul 23, doi: 10.1161/HCG.0000000000000067.

  27. Marstrand P, Han L, Day SM, Olivotto I, Ashley EA, Michels M, Pereira AC, Wittekind SG, Helms AS, Saberi S, Jacoby D, Ware JS, Colan SD, Semsarian C, Ingles J, Lakdawala N, Ho CY. Hypertrophic Cardiomyopathy with Left Ventricular Systolic Dysfunction: Insights from the SHaRe Registry. Circulation 2020 Mar 31. doi: 10.1161.

  28. Balasubramanian S, Saberi S, Yu S, Duvernoy C, Day SM, Agarwal P. Women Representation Among Cardiology Journal Editorial Boards. Circulation 2020, Feb 18;141(7):603-605

  29. Toepfer CN, Agarwal R, Ewoldt J, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, Jacoby D, Michels M, Redwood C, Watkins H, Day SM, Staples J, Padron R, Chopra A, Chen C, Ho C, Pereira A, Seidman J, Seidman CE. Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation 2020 Mar 10;141(10):828-842.  PMCID:  PMC7077965

  30.  Helms AS, Tang V, O’Leary TS, Friedline S, Wauchope M, Arora K, Wasserman AH, Smith ED, Lee LM, Wen XW, Shavit JA, Liu AP, Previs MJ, Day SM. Effects of MYBPC3 Loss of Function Mutations Preceding Hypertrophic Cardiomyopathy, JCI Insight 2020 Jan 30;5(2). Pii:133782. Doi:10.1172. PMCID:  PMC7098724

  31. Eberly L, Day SM, Ashley EA, Jacoby D, Jefferies J, Colan SD, Rossano J, Semsarian C, Pereira AC, Olivotto I, Ingles J, Seidman CE, Channaoui C, Cirino AL, Han L, Ho CY, Lakdawala NK. Racial Differences in Disease Expression and Clinical Outcomes in Hypertrophic Cardiomyopathy in the United States. JAMA Cardiology 2019 Dec 4. Doi: 10.1001/jamacardio.2019.4638  PMCID:  PMC6902181

  32. Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan S, Margossian R, Hall EK, Becker J, Jefferies JL, Patal A, Choudhury L, Murphy A, Canter C, Bach R, Taylor M, Mestroni L, Wheeler M, Benson L, Owens A, Rossano J, Lin K, Pahl E, Pereira A, Bundgaard H, Lewis G, Vargas J, Cirino A, McMurray J, MacRae C. Solomon S, Orav EJ, Braunwald E, Ho C. Baseline characteristics of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy Cohort. Circulation: Heart Failure 2019 Dec;12(12):e006231.

  33.  Fumagalli C, Maurizi N, Day SM, Ashley EA, Michels M, Colan SD, Jacoby D, Marchionni N, Vincent-Tompkins J, Ho CY, Olivotto I. Association of Obesity with Adverse Long-Term Outcomes in Hypertrophic Cardiomyopathy. JAMA Cardiology 2019 Nov 6:1-8.  PMCID:  PMC6865784

  34. Garratt M, Leander D, Pifer K, Herrera J, Day SM, Fiehn O, Brooks S, Miller RA. 17-a Estradiol Ameliorates Age-Associated Sarcopenia and Improves Late Life Physical Function in Male Mice But Not in Females or Castrated Males. Aging Cell 2019 Apr;18(2):e12920.

  35. Walsh R, Mazzarotto F, Whiffin N, Buchan R, Midwinter W, Wilk A, Li N, Felkin L, Ingold N, Govind R, Ahm,ad M, Mazaika E, Allouba M, Zhang X, de Marvao A, Day SM, Ashley E, Colan SD, Michels M, Pereira AC, Jacoby D, Ho CY, Thomson KL, Watkins H, Barton PJR, Olivotto, I, Cook SA, Ware JS. Quantitative Approaches to Variant Classification Increase the Yield and Precision of Genetic Testing for Mendelian Diseases: The Case for Hypertrophic Cardiomyopathy. Genome Medicine 2019 Jan 29;11(1):5.  PMCID:  PMC6350371

  36. Day SM. Nonobstructive Hypertrophic Cardiomyopathy: The High Hanging Fruit. JAMA Cardiology 2019 Feb 6.doi:10.1001/jamacardio.2018.4953

  37. O’Leary T, Snyder J, Sadayappan S, Day SM, Previs MJ. MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology 2019 Feb;127:165-173  PMCID:  PMC6592272

  38. Ahmad F, McNally EM, Ackerman MJ, Baty LC, Day SM, Kullo IJ, Madueme PC, Maron MS, Martinez MW, Phetteplace JE, Salberg L, Taylor MR. Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting the Standards. Circulation Genomics and Precision Medicine 2019, Jun;12(6):e000054.

  39. Glazier A, Thompson A, Day SM. Allelic Imbalance and Haploinsufficiency in MYBPC3 Mutations. Plugers Archiv: European Journal of Physiology 2019 May;471(5):781-793.  PMCID:  PMC6476680
  40. Vigneault DM, Yang E, Jensen PJ, Tee MW, Harhad H, Chu L, Noble JA, Day SM, Colan SD, Russell MW, Towbin J, Sherrid MV, Canter CE, Shi L, Ho CY, Bluemke DA. Left Ventricular Strain is Abnormal in Preclinical and Overt Hypertrophic Cardiomyopathy: Cardiac MR Feature Tracking. Radiology 2018 Dec 18:180339. Doi: 10.1148/radiol.2018180339.  PMCID:  PMC6394738
  41. Lee SP, Ashley EA, Homburger J, Caleshu C, Green EM, Jacoby D, Colan SD, Fernandez EA, Day SM, Girolami F, Olivotto I, Michels M, Ho CY, Perez MV. Incident Atrial Fibrillation is Associated with MYH7 Sarcomeric Gene Variation in Hypertrophy Cardiomyopathy: Results from the International Sarcomeric Human Cardiomyopathy Registry. Circulation Heart Failure 2018;11:e005191. DOI: 10.1161/CIRCHEARTFAILURE.118.005191.  
  42. Smith ED, Tome J, Mcgrath R, Kumar S, Concannon M, Day SM, Saberi S, Helms AS. Abnormal Blood Pressure Response Identifies Heart Failure Risk in Hypertrophic Cardiomyopathy. Int J Cardiol 2018, 10.1016/j.ijcard.2018.07.110.
  43. Ho CY, Day SM, Ashley EA, Michels M, Pereira A, Jacoby D, Fox J, Caleshu C, Cirino AL, Ware J, Helms AS, Colan SD, Signorovich J, Green E, Olivotto I. Examining Natural History and Genotype-Phenotype Correlations in Hypertrophic Cardiomyopathy: Findings from the Sarcomeric Human Cardiomyopathy Registry. Circulation 2018;138(14):1387-1398
  44. Glazier A, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii A, Tang V, Yob J, Gestwicki J, Helms AS, Day SM. HSC70 is a Chaperone for Wild-type and Mutant Cardiac Myosin Binding Protein C. JCI Insight 2018, 10.1172/jci.insight.99319.  PMCID:  PMC6124431
  45. Masarone D, Kaski JP, Pacileo G, Elliott PM, Bossone E, Day SM, Limongelli G. Epidemiology and Clinical Aspects of Genetic Cardiomyopathies. Heart Failure Clinics of North America 2018;14(2):121-128.
  46. Limongelli G, Bossone E, Elliott P, Day SM. Preface: On the Road from Gene to Therapy in Inherited Cardiomyopathies. Heart Failure Clinics of North America 2018;14(2):xi-xv.
  47. Tang V, Arscott P, Helms AS, Day SM. Whole Exome Sequencing Reveals GATA4 and PTEN Mutations as a Potential Digenic Cause of Left Ventricular Noncompaction. Circulation: Genomic and Precision Medicine 2018;11:e001966 DOI:10.1161/CIRCGEN.117.001966
  48. Saberi S, Day SM. Exercise and HCM – Time for a Change of Heart. Circulation 2018;137(5):419-21.
  49. Saberi S, Day SM. Vigorous Exercise in HCM: Benefits May Outweigh the Risks. Int J Cardiol 2018;250:229-230.
  50. Ko C, Arscott P, Saberi S, Concannon M, Day SM, Yashar BM, Helms AS. Genetic Testing Impacts the Utility of Prospective Familial Screening in Hypertrophic Cardiomyopathy Through Identification of a Non-Familial Subgroup. Genetics in Medicine 2018;20(1):69-75.
  51. Ho JE, Shi L, Day SM, Colan SD, Russell M, Towbin JA, Sherrid MV, Canter CE, Murphy A, Mestroni L, Cirino AL, Sleeper LA, Jarolim P, Lopez B, Gonzalex A, Peiz J, Orav JE, Ho C. Biomarkers of Cardiovascular Stress and Fibrosis in Preclinical Hypertrophic Cardiomyopathy. OpenHeart 2017;4:e000615.doi:10.1136/openhrt-2017-00615.  PMCID:  PMC5687543
  52. Cirino AL, Harris S, Lakdawala NK, Michels M, Olivotto I, Day SM, Abrams DJ, Charon P, Caleshu C, Semsarian C, Ingles J, Rakowski H, Judge DP, Ho CY. Role of Genetic Testing in Inherited Cardiac Disease. JAMA Cardiology 2017 Aug 9. doi: 10.1001/jamacardio.2017.2352
  53. Thompson AD, Day SM. Founder Mutations in Myosin Binding Protein C: Maybe not so benign after all. Circulation: Cardiovascular Genetics 2017 Aug;10(4). pii: e001872. doi: 10.1161/CIRCGENETICS.117.001872
  54. Ho CY, Cirino AL, Colan SD, Day SM, Desai A, Lipshultz SE, MacRae CA, McMurray JJV, Solomon SD, Shi L, Orav EJ, Braunwald E. Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy: The VANISH Trial Protocol. American Heart Journal 2017 May;187:145-155
  55. Helms AS, Day SM. Other Side of the Coin: Missing Heritability in Hypertrophic Cardiomyopathy. European Heart Journal 2017;13.doi:10.1093/eurheartj/ehx024.
  56. Ho CY, Day SM, Colan SD, Russell MW, Towbin J, Sherrid M, Canter CE, Jeffries JL, Murphy A, Taylor M, Mestroni L, Cirino AL, Bluemke DA, Abraham TP, Jarolim P, Sleeper LA, Shi L, Seidman CE, Orav EJ for the HCMNet Investigators. The Burden of Early Phenotypes and the Impact of Left Ventricular Wall Thickness on Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers: Findings from the HCMNet Study. JAMA Cardiology 2017;2(4):419-428.
  57. Saberi S, Wheeler M, Bragg-Gresham J, Hornsby W, Agarwal P, Attili A, Concannon M, Dries AM, Schmargad Y, Salisbury H, Kumar S, Herrera J, Myers J, Helms AS, Ashley EA, Day SM. Effect of Moderate Intensity Exercise Training on Peak Oxygen Consumption in Patients with Hypertrophic Cardiomyopathy, A Randomized Clinical Trial. JAMA 2017;317(13):1349-1357. Accompanying editorial, JAMA 2017;317(13):1319-1320.  PMCID:  PMC5469299
  58. Helms AS, Alvarado F, Yob JM, Tang V, Bartolone S, Pagani F, Russell MW, Valdivia H, Day SM. Genotype Dependent Calcium Signaling Dysfunction in Human Hypertrophic Cardiomyopathy. Circulation 2016;134:1738-1748. Accompanying editorial, Circulation 2016;134:1749-1751  PMCID:  PMC5127749