Pennsylvania Muscle Institute Annual Symposium


Intermediate Filaments
Cytoskeletal Mechanics, Motility, and the Nucleus


November 12, 2018


Location: Arthur H. Rubenstein Auditorium
Smilow Center for Translational Research
3400 Civic Center Blvd



Keynote Lectures:



Sandrine Etienne-Manneville, PhD
Institut Pasteur
"Intermediate filaments in cell migration"

Robert D. Goldman, PhD
Northwestern University
“The roles of intermediate filaments in regulating cytoskeletal crosstalk, cell mechanics and motility”

Sylvie Hénon, PhD
University of Paris, Diderot
"Role of desmin and desmin mutation in passive and active mechanical properties of myoblasts"

Jan Lammerding, PhD
Cornell University
“Mutant lamins cause mechanically-induced nuclear envelope rupture, DNA damage, and DNA-PK activation in muscle”


Local Lectures:



Irena Ivanovska, PhD (Discher Lab)
University of Pennsylvania
"Nuclear rupture at sites of high curvature compromises retention of DNA repair factors"

Julie Heffler (Prosser Lab)
University of Pennsylvania
"Desmin protects cardiomyocyte nuclei from microtubule-dependent collapse"

A. Sue Menko, PhD
Thomas Jefferson University
"Does vimentin have distinct functions in wound repair and fibrosis?"

Alison E. Patteson, PhD (Janmey Lab)
University of Pennsylvania
"Loss of vimentin intermediate filaments decreases peri-nuclear stiffness and enhances cell motility through confined spaces"


Poster session, plus student and post-doc oral presentations selected from abstracts

Download Poster

Schedule of Events

TIME

PLACE

EVENT DESCRIPTION

8:30 – 9:00

Smilow Commons

Registration

9:00 - 9:15

Smilow Auditorium

Welcome
E. Michael Ostap, PhD - Director, Pennsylvania Muscle Institute and Professor of Physiology

Robert E. Davies Honorary Lectures

9:15 - 10:00

Smilow Auditorium

Robert D. Goldman, PhD
Northwestern University
“The roles of intermediate filaments in regulating cytoskeletal crosstalk, cell mechanics and motility”

10:00 - 10:30

Smilow Auditorium

Irena Ivanovska, PhD (Discher Lab)
University of Pennsylvania
"Nuclear rupture at sites of high curvature compromises retention of DNA repair factors"

10:30 - 11:00

Smilow Auditorium

Coffee, Posters, Vendors

11:00 - 11:45

Smilow Auditorium

A. Sue Menko, PhD
Thomas Jefferson University
"Does vimentin have distinct functions in wound repair and fibrosis?"

11:45 - 12:30

Smilow Auditorium

Sandrine Etienne-Manneville, PhD
Institut Pasteur
"Intermediate filaments in cell migration"

12:30 - 1:30

Smilow Commons

Lunch, Poster Session, and Vendors

Andrew P. Somlyo Honorary Lectures

1:30 - 2:00

Smilow Auditorium

Alison E. Patteson, PhD (Janmey Lab)
University of Pennsylvania
"Loss of vimentin intermediate filaments decreases peri-nuclear stiffness and enhances cell motility through confined spaces"

2:00 - 2:45

Smilow Auditorium

Sylvie Hénon, PhD
University of Paris, Diderot
"Role of desmin and desmin mutation in passive and active mechanical properties of myoblasts"

2:45 - 3:15

Smilow Commons

Coffee Break and Poster Session

3:15 - 3:45

Smilow Auditorium

Julie Heffler (Prosser Lab)
University of Pennsylvania
"Desmin protects cardiomyocyte nuclei from microtubule-dependent collapse"

3:45 - 4:30

Smilow Auditorium

Jan Lammerding, PhD
Cornell University
“Mutant lamins cause mechanically-induced nuclear envelope rupture, DNA damage, and DNA-PK activation in muscle”

4:30 - 5:30

Smilow Commons

Reception

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