News

See below for the latest news regarding PMI-sponsored events and notable accomplishments by our members and their labs.

June 11, 2024
Announcing the appointment of Erika L. F. Holzbaur, PhD, as the new Director of the Pennsylvania Muscle Institute
Please join us in congratulating Dr. Erika Holzbaur! | Dr. Michael Ostap, interim Chief Scientific Office for PSOM & Dr. Kevin Foskett, Chair of the Department of Physiology, are pleased to announce the appointment of Dr. Erika L. F. Holzbaur as the new director of the Pennsylvania Muscle Institute (PMI), effective May 1, 2024.
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June 6, 2024
Utilizing UPenn’s cryo-EM facility, Nick Palmer and Kyle Barrie, students in the Dominguez Lab, have just published in Nature (https://rdcu.be/dJ8mW) the cryo-EM structures of INF2 and Dia1 that now provide a step-by-step visualization of the mechanisms of actin filament severing and elongation.
In 2002, Sally Zigmond and other UPenn/PMI scientists made the seminal discovery of formin’s ability to nucleate and elongate actin filaments (Science; DOI: 10.1126/science.1072309). Utilizing UPenn’s cryo-EM facility, Nick Palmer and Kyle Barrie, students in the Dominguez Lab, have just published in Nature (https://rdcu.be/dJ8mW) the cryo-EM structures of INF2 and Dia1 that now provide a step-by-step visualization of the mechanisms of actin filament severing and elongation, bringing this story full-circle here at Penn! The implications of this study are profound since formin dysfunction is linked to pathologies, including cardiomyopathies, cancers, and neurological disorders. Mutations in the two formins studied in their paper, INF2 and Dia1, produce focal segmental glomerulosclerosis and Charcot-Marie-Tooth neuropathy (INF2), and deafness (Dia1). Please join us in congratulating the Dominguez Lab on this accomplishment!! | Palmer, N.J., Barrie, K.R. & Dominguez, R. Mechanisms of actin filament severing and elongation by formins. Nature (2024). https://doi.org/10.1038/s41586-024-07637-0
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April 22, 2024
Appointment of Michael Ostap, PhD, as interim Senior Vice Dean and Chief Scientific Officer for the Perelman School of Medicine
Please join us in congratulating Dr. Michael Ostap as interim Senior Vice Dean and Chief Scientific Officer for the Perelman School of Medicine!
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April 19, 2024
Congratulations to Adam Fenton (Holzbaur and Jongens Labs) for receiving the 2024 Saul Winegrad Award for Outstanding Dissertation.
Congratulations to Adam Fenton (Holzbaur and Jongens Labs) for receiving the 2024 Saul Winegrad Award for Outstanding Dissertation. The Saul Winegrad Award for Outstanding Dissertation was established in 1995 in honor of the founding Director of BGS, Saul Winegrad, MD, Emeritus Professor of Physiology. The award was created to recognize a dissertation of outstanding quality which makes a significant contribution to biomedical science.
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January 5, 2024
Spring 2024 Seminar Series Dates
Spring 2024 Physiology/PMI Seminar Series Dates
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November 20, 2023
December 8: PMI Holiday Social 2023
Save the date for our annual PMI Holiday Social!
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October 4, 2023
Fall 2023 Physiology PMI Seminar Series Dates
Please see our list of speakers for our Fall 2023 dates.
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September 20, 2023
Register by 10/9! Speakers and talk titles announced - PMI Annual Retreat and Symposium.
Register by 10/9! Speakers and talk titles announced - PMI Annual Retreat and Symposium.
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August 22, 2023
Registration open! PMI Annual Symposium - Mon. October 16, 2023
"Celebrating 50 Years of Muscle, Motors, and the Cytoskeleton" - register now for the PMI Annual Symposium on 10/16/2023. (Deadline: Oct. 9, 2023)
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