Dr. Paul Titchenell will be one of the speakers at ASMB 2025
See the terrific line-up of confirmed speakers, including Dr. Paul Titchenell, for the 2025 Advances in Skeletal Muscle Biology (ASMB) Conference. Register soon to have the opportunity to hear from these, and more to come, renowned speakers! March 19-21, 2025 on the University of Florida campus Gainesville, FL.
Save the date: October 1 - PMI Science Social: Trainees Elevator Pitches
Our first PMI Science Social Hour of the fall is coming up on October 1, from 3:00-5:00 PM. Please come catch-up with PMI colleagues while enjoying snacks and drinks.
For this session, PMI trainees will have the opportunity to practice their scientific elevator pitches; sign-ups now open!
Announcing the appointment of Erika L. F. Holzbaur, PhD, as the new Director of the Pennsylvania Muscle Institute
Please join us in congratulating Dr. Erika Holzbaur! | Dr. Michael Ostap, interim Chief Scientific Office for PSOM & Dr. Kevin Foskett, Chair of the Department of Physiology, are pleased to announce the appointment of Dr. Erika L. F. Holzbaur as the new director of the Pennsylvania Muscle Institute (PMI), effective May 1, 2024.
Utilizing UPenn’s cryo-EM facility, Nick Palmer and Kyle Barrie, students in the Dominguez Lab, have just published in Nature (https://rdcu.be/dJ8mW) the cryo-EM structures of INF2 and Dia1 that now provide a step-by-step visualization of the mechanisms of actin filament severing and elongation.
In 2002, Sally Zigmond and other UPenn/PMI scientists made the seminal discovery of formin’s ability to nucleate and elongate actin filaments (Science; DOI: 10.1126/science.1072309). Utilizing UPenn’s cryo-EM facility, Nick Palmer and Kyle Barrie, students in the Dominguez Lab, have just published in Nature (https://rdcu.be/dJ8mW) the cryo-EM structures of INF2 and Dia1 that now provide a step-by-step visualization of the mechanisms of actin filament severing and elongation, bringing this story full-circle here at Penn! The implications of this study are profound since formin dysfunction is linked to pathologies, including cardiomyopathies, cancers, and neurological disorders. Mutations in the two formins studied in their paper, INF2 and Dia1, produce focal segmental glomerulosclerosis and Charcot-Marie-Tooth neuropathy (INF2), and deafness (Dia1). Please join us in congratulating the Dominguez Lab on this accomplishment!! | Palmer, N.J., Barrie, K.R. & Dominguez, R. Mechanisms of actin filament severing and elongation by formins. Nature (2024). https://doi.org/10.1038/s41586-024-07637-0
Congratulations to Adam Fenton (Holzbaur and Jongens Labs) for receiving the 2024 Saul Winegrad Award for Outstanding Dissertation.
Congratulations to Adam Fenton (Holzbaur and Jongens Labs) for receiving the 2024 Saul Winegrad Award for Outstanding Dissertation.
The Saul Winegrad Award for Outstanding Dissertation was established in 1995 in honor of the founding Director of BGS, Saul Winegrad, MD, Emeritus Professor of Physiology. The award was created to recognize a dissertation of outstanding quality which makes a significant contribution to biomedical science.
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