The latest publications by PMI members and their labs.
Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity
Voos KM, Tzeng J, Patel P, Rubinsky S, Choi HE, Pharr T, Sookram S, Soderblom E, Baur J, Lorenzo DN. (2025) Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity. Nature Communications. 16: 7671.
Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression
Vinayak V, Basir R, Golloshi R, Toth J, Sant’Anna L, Lakadamyali M, McCord RP, Shenoy VB. Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression. Nat Commun. 2025 Apr 23;16(1):3816. doi: 10.1038/s41467-025-59001-z. PMID: 40268925; PMCID: PMC12019571.
Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis
Basak B, Holzbaur ELF. Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis. J Mol Biol. 2025 Apr 21:169161. doi: 10.1016/j.jmb.2025.169161. Epub ahead of print. PMID: 40268233.
Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction
Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, Kelly DP. Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction. ESC Heart Fail. 2025 Apr 15. doi: 10.1002/ehf2.15285. Epub ahead of print. PMID: 40232999.
Long range mutual activation establishes Rho and Rac polarity during cell migration
De Belly H, Gallen AF, Strickland E, Estrada DC, Zager PJ, Burkhardt JK, Turlier H, Weiner OD. Long range mutual activation establishes Rho and Rac polarity during cell migration. bioRxiv [Preprint]. 2024 Oct 2:2024.10.01.616161. doi: 10.1101/2024.10.01.616161. PMID: 40236007; PMCID: PMC11996577.
Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage
Peshkova AD, Rednikova EK, Khismatullin RR, Kim OV, Muzykantov VR, Purohit PK, Litvinov RI, Weisel JW. Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage. Blood Adv. 2025 Apr 16:bloodadvances.2024015533. doi: 10.1182/bloodadvances.2024015533. Epub ahead of print. PMID: 40238947.
Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation
Yuan Z, Janmey PA, McCulloch CA. Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation. Cell Commun Signal. 2025 Apr 18;23(1):187. doi: 10.1186/s12964-025-02194-z. PMID: 40251523; PMCID: PMC12007377.
A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Iu E, Bogatch A, Deng W, Humphries JD, Yang C, Valencia FR, Li C, McCulloch CA, Tanentzapf G, Svitkina TM, Humphries MJ, Plotnikov SV. A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration. bioRxiv [Preprint]. 2025 Mar 30:2025.03.28.646012. doi: 10.1101/2025.03.28.646012. PMID: 40196692; PMCID: PMC11974816.
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P; Penn Medicine Biobank; Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM. Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. Nat Genet. 2025 Apr;57(4):829-838. doi: 10.1038/s41588-025-02140-2. Epub 2025 Apr 7. PMID: 40195560.
Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch
Demidov VM, Gonchar IV, Tripathy SK, Ataullakhanov FI, Grishchuk EL. Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch. bioRxiv [Preprint]. 2025 Mar 13:2025.03.13.643154. doi: 10.1101/2025.03.13.643154. PMID: 40161670; PMCID: PMC11952512.
Single cell transcriptomic analyses of human heart failure with preserved ejection fraction
Hahn VS, Chaffin M, Simonson B, Jenkin S, Mulligan AS, Bedi K, Margulies KB, Klattenhoff C, Sharma K, Kass DA, Ellinor PT. Single cell transcriptomic analyses of human heart failure with preserved ejection fraction. bioRxiv [Preprint]. 2025 Mar 12:2025.03.06.641949. doi: 10.1101/2025.03.06.641949. PMID: 40161758; PMCID: PMC11952296.
Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states
Cail RC, Báez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM. Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states. J Biol Chem. 2025 Mar 19;301(5):108412. doi: 10.1016/j.jbc.2025.108412. Epub ahead of print. PMID: 40118457.
Clinical signatures of SYNGAP1-related disorders through data integration
McKee JL, Magielski JH, Xian J, Cohen S, Toib J, Harrison A, Chen C, Kim D, Rathod A, Brimble E, Fitter N, Graglia JM, Helde KA, McKeown Ruggiero S, Boland MJ, Prosser BL, Sederman R, Helbig I. Clinical signatures of SYNGAP1-related disorders through data integration. Genet Med. 2025 Mar 19:101419. doi: 10.1016/j.gim.2025.101419. Epub ahead of print. PMID: 40119723.
Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure
Latchman NR, Stevens TL, Bedi KC, Prosser BL, Margulies KB, Elrod JW. Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure. bioRxiv [Preprint]. 2025 Jan 29:2025.01.29.635600. doi: 10.1101/2025.01.29.635600. PMID: 39975328; PMCID: PMC11838275.
Matrix stiffness induces heritable changes in chromosome numbers, consistent with solid tumor heterogeneity
Anlaş AA, Sprenger MT, Wang M, Ontko N, Phan S, Discher DE. Matrix stiffness induces heritable changes in chromosome numbers, consistent with solid tumor heterogeneity. bioRxiv [Preprint]. 2025 Jan 30:2025.01.28.635370. doi: 10.1101/2025.01.28.635370. PMID: 39975263; PMCID: PMC11838315.
ROR2 drives right ventricular heart failure via disruption of proteostasis
Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ. ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv [Preprint]. 2025 Feb 2:2025.02.01.635961. doi: 10.1101/2025.02.01.635961. PMID: 39975092; PMCID: PMC11838457.
Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration
Oak ASW, Bagchi A, Brukman MJ, Toth J, Ford J, Zheng Y, Nace A, Yang R, Hsieh JC, Hayden JE, Ruthel G, Ray A, Kim E, Shenoy VB, Cotsarelis G. Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration. Sci Adv. 2025 Feb 21;11(8):eadq0638. doi: 10.1126/sciadv.adq0638. Epub 2025 Feb 19. PMID: 39970220; PMCID: PMC11838001.
Poroelasticity and permeability of fibrous polymer networks under compression
Mollenkopf P, Kochanowski JA, Ren Y, Vining KH, Janmey PA, Purohit PK. Poroelasticity and permeability of fibrous polymer networks under compression. Soft Matter. 2025 Mar 26;21(13):2400-2412. doi: 10.1039/d4sm01223b. PMID: 39976571; PMCID: PMC11841696.
Mature murine supraspinatus tendons demonstrate regional differences in multiscale structure, function and gene expression
DiStefano MS, Weiss SN, Nuss CA, Betts RL, Han B, Kuntz AF, Soslowsky LJ. Mature murine supraspinatus tendons demonstrate regional differences in multiscale structure, function and gene expression. PLoS One. 2025 Feb 20;20(2):e0318809. doi: 10.1371/journal.pone.0318809. PMID: 39977400; PMCID: PMC11841869.
Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation
Uchida K, Scarborough EA, Prosser BL. Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation. bioRxiv [Preprint]. 2025 Feb 11:2025.02.10.635974. doi: 10.1101/2025.02.10.635974. PMID: 39990478; PMCID: PMC11844361.
The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy
Berkowitz J, Sagaityte E, Khalid M, Lopez D, Mohebali D, Bello N, Arany Z, French K, Poppas A, Sabe M, Wu WC, Joseph J, Djousse L, Choudhary G, Imran TF. The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy. Clin Res Cardiol. 2025 Feb 24. doi: 10.1007/s00392-025-02615-6. Epub ahead of print. PMID: 39992386.
High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory
Chavali SS, Carman PJ, Shuman H, Ostap EM, Sindelar CV. High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory. Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e2415457122. doi: 10.1073/pnas.2415457122. Epub 2025 Feb 27. PMID: 40014570; PMCID: PMC11892617.
Exploring the thrombus niche: Lessons learned and potential therapeutic opportunities
Weisel JW, Litvinov RI. Exploring the thrombus niche: Lessons learned and potential therapeutic opportunities. Blood. 2025 Feb 28:blood.2024025319. doi: 10.1182/blood.2024025319. Epub ahead of print. PMID: 40019439.
Ubiquitous clot contraction blockers hit ubiquitin and more
Weisel JW, Litvinov RI. Ubiquitous clot contraction blockers hit ubiquitin and more. Blood Adv. 2025 Mar 11;9(5):1092-1094. doi: 10.1182/bloodadvances.2024014973. PMID: 40019777; PMCID: PMC11938070.
Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction
Kliuchnikov E, Peshkova AD, Vo MQ, Marx KA, Litvinov RI, Weisel JW, Purohit PK, Barsegov V. Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction. NPJ Biol Phys Mech. 2025;2(1):6. doi: 10.1038/s44341-025-00011-9. Epub 2025 Feb 24. PMID: 40012560; PMCID: PMC11850289.
PRDM16 controls smooth muscle cell fate in atherosclerosis
Tan JME, Cheng L, Calhoun RP, Weller AH, Drareni K, Fong S, Barbara E, Lim HW, Xue C, Winter H, Auguste G, Miller CL, Reilly MP, Maegdefessel L, Lutgens E, Seale P. PRDM16 controls smooth muscle cell fate in atherosclerosis. bioRxiv [Preprint]. 2025 Feb 23:2025.02.19.639186. doi: 10.1101/2025.02.19.639186. PMID: 40027729; PMCID: PMC11870537.
Adaptive evolution of CENP-T modulates centromere binding
Dudka D, Nguyen AL, Boese KG, Marescal O, Akins RB, Black BE, Cheeseman IM, Lampson MA. Adaptive evolution of CENP-T modulates centromere binding. Curr Biol. 2025 Mar 10;35(5):1012-1022.e5. doi: 10.1016/j.cub.2025.01.017. Epub 2025 Feb 12. PMID: 39947176; PMCID: PMC11903153.
Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling
Islam M, Rawnsley DR, Ma X, Navid W, Zhao C, Guan X, Foroughi L, Murphy JT, Navid H, Weinheimer CJ, Kovacs A, Nigro J, Diwan A, Chang RP, Kumari M, Young ME, Razani B, Margulies KB, Abdellatif M, Sedej S, Javaheri A, Covey DF, Mani K, Diwan A. Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling. J Clin Invest. 2025 Feb 11:e163730. doi: 10.1172/JCI163730. Epub ahead of print. PMID: 39932799.
Genes of the Fatty Acid Oxidation Pathway are Upregulated in Female as Compared to Male Cardiomyocytes
Talukdar M, Chm√°tal L, Mao L, Reichart D, Murashige DS, Skaletsky H, DeLaughter DM, Arany Z, Seidman JG, Seidman CE, Page DC. Genes of the Fatty Acid Oxidation Pathway are Upregulated in Female as Compared to Male Cardiomyocytes. Circulation. 2025 Feb 18;151(7):511-514. doi: 10.1161/CIRCULATIONAHA.124.071973. Epub 2025 Feb 17. PMID: 39960981.
3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function
Park G, Grey JA, Mourkioti F, Han WM. 3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function. Adv Biol (Weinh). 2025 Mar 4:e2400717. doi: 10.1002/adbi.202400717. Epub ahead of print. PMID: 40040295.
NPF binding to Arp2 is allosterically linked to the release of ArpC5’s N-terminal tail and conformational changes in Arp2/3 complex
Saks AJ, Barrie KR, Rebowski G, Dominguez R. NPF binding to Arp2 is allosterically linked to the release of ArpC5’s N-terminal tail and conformational changes in Arp2/3 complex. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2421557122. doi: 10.1073/pnas.2421557122. Epub 2025 Feb 18. PMID: 40042350; PMCID: PMC11873952.
Do actin isoforms have unique functionalities at the protein level?
Ervasti JM, Kashina AS, Perrin BJ. Do actin isoforms have unique functionalities at the protein level? Nat Commun. 2025 Mar 7;16(1):2240. doi: 10.1038/s41467-025-57103-2. PMID: 40055341; PMCID: PMC11889098.
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
Shimogawa M, Li MH, Park GSH, Ramirez J, Lee H, Watson PR, Sharma S, Lin Z, Peng C, Garcia BA, Christianson DW, Rhoades E, Eliezer D, Petersson EJ. Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis. bioRxiv [Preprint]. 2025 Jan 27:2025.01.21.634178. doi: 10.1101/2025.01.21.634178. PMID: 39896484; PMCID: PMC11785115.
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
Lee WD, Weilandt DR, Liang L, MacArthur MR, Jaiswal N, Ong O, Mann CG, Chu Q, Hunter CJ, Ryseck RP, Lu W, Oschmann AM, Cowan AJ, TeSlaa TA, Bartman CR, Jang C, Baur JA, Titchenell PM, Rabinowitz JD. Lactate homeostasis is maintained through regulation of glycolysis and lipolysis. Cell Metab. 2025 Jan 29:S1550-4131(24)00491-1. doi: 10.1016/j.cmet.2024.12.009. Epub ahead of print. PMID: 39889702.
Immunomodulatory Therapy for Ischemic Heart Disease
Zhao X, Williamson T, Gong Y, Epstein JA, Fan Y. Immunomodulatory Therapy for Ischemic Heart Disease. Circulation. 2024 Sep 24;150(13):1050-1058. doi: 10.1161/CIRCULATIONAHA.124.070368. Epub 2024 Sep 23. PMID: 39325497; PMCID: PMC11521113.
Mechanism of Actin Filament Severing and Capping by Gelsolin
Barrie KR, Rebowski G, Dominguez R. Mechanism of Actin Filament Severing and Capping by Gelsolin. bioRxiv [Preprint]. 2024 Sep 23:2024.09.10.612341. doi: 10.1101/2024.09.10.612341. Update in: Nat Struct Mol Biol. 2024 Oct 24. doi: 10.1038/s41594-024-01412-5. PMID: 39345426; PMCID: PMC11430012.
Learning on a Limb: An outreach module to engage high school students in orthopaedics
Panebianco CJ, Azar TF, Duffy MP, Nijsure MP, Sharp E, Tamburro MK, Hast M, Shore EM, Mauck RL, Soslowsky LJ, Shuda JR, Gullbrand SE. Learning on a Limb: An outreach module to engage high school students in orthopaedics. bioRxiv [Preprint]. 2024 Sep 18:2024.09.16.612729. doi: 10.1101/2024.09.16.612729. Update in: J Orthop Res. 2024 Nov 7. doi: 10.1002/jor.26010. PMID: 39345492; PMCID: PMC11430081.
Precision Repair of Zone-Specific Meniscal Injuries Using a Tunable Extracellular Matrix-Based Hydrogel System
Lee SH, Li Z, Zhang EY, Kim DH, Huang Z, Lee SJ, Kang HW, Burdick JA, Mauck RL, Heo SC. Precision Repair of Zone-Specific Meniscal Injuries Using a Tunable Extracellular Matrix-Based Hydrogel System. bioRxiv [Preprint]. 2024 Sep 17:2024.09.12.612723. doi: 10.1101/2024.09.12.612723. PMID: 39345590; PMCID: PMC11429709.
Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
Dooling LJ, Anlaş AA, Tobin MP, Ontko NM, Marchena T, Wang M, Andrechak JC, Discher DE. Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613918. doi: 10.1101/2024.09.19.613918. PMID: 39345601; PMCID: PMC11430028.
Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision
Deng C, Lan YC, Chen GY, Ekeabu CS, Chung M, Lampson MA, Chenoweth DM. Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision. bioRxiv [Preprint]. 2024 Sep 15:2024.09.12.612697. doi: 10.1101/2024.09.12.612697. PMID: 39314350; PMCID: PMC11419097.
Regulatory Role of Collagen XI in the Establishment of Mechanical Properties of Tendons and Ligaments in Mice Is Tissue Dependent
Ye Y, Shetye SS, Birk DE, Soslowsky LJ. Regulatory Role of Collagen XI in the Establishment of Mechanical Properties of Tendons and Ligaments in Mice Is Tissue Dependent. J Biomech Eng. 2025 Jan 1;147(1):011003. doi: 10.1115/1.4066570. PMID: 39297758; PMCID: PMC11500803.
Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics
Doan KV, Luongo TS, Ts’olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA. Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nat Cardiovasc Res. 2024 Oct;3(10):1236-1248. doi: 10.1038/s44161-024-00542-9. Epub 2024 Sep 18. PMID: 39294272.
Bridging structural biology and clinical research through in-tissue cryo-electron tomography
Kixmoeller K, Creekmore BC, Lee EB, Chang YW. Bridging structural biology and clinical research through in-tissue cryo-electron tomography. EMBO J. 2024 Nov;43(21):4810-4813. doi: 10.1038/s44318-024-00216-z. Epub 2024 Sep 16. PMID: 39284913; PMCID: PMC11534999.
Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders
Cali E, Quirin T, Rocca C, Efthymiou S, Riva A, Marafi D, Zaki MS, Suri M, Dominguez R, Elbendary HM, Alavi S, Abdel-Hamid MS, Morsy H, Mau-Them FT, Nizon M, Tesner P, Ryba L, Zafar F, Rana N, Saadi NW, Firoozfar Z, Gencpinar P, Unay B, Ustun C, Bruel AL, Coubes C, Stefanich J, Sezer O, Agolini E, Novelli A, Vasco G, Lettori D, Milh M, Villard L, Zeidler S, Opperman H, Strehlow V, Issa MY, El Khassab H, Chand P, Ibrahim S, Nejad-Rashidi A, Miryounesi M, Larki P, Morrison J, Cristian I, Thiffault I, Bertsch NL, Noh GJ, Pappas J, Moran E, Marinakis NM, Traeger-Synodinos J, Hosseini S, Abbaszadegan MR, Caumes R, Vissers LELM, Neshatdoust M, Montazer MZ, El Fahime E, Canavati C, Kamal L, Kanaan M, Askander O, Voinova V, Levchenko O, Haider S, Halbach SS, Maia ER, Mansoor S, Vivek J, Tawde S, Santhosh R Challa V, Gowda VK, Srinivasan VM, Victor LA, Pinero-Banos B, Hague J, Ei-Awady HA, Maria de Miranda Henriques-Souza A, Cheema HA, Anjum MN, Idkaidak S, Alqarajeh F, Atawneh O, Mor-Shaked H, Harel T, Zifarelli G, Bauer P, Kok F, Kitajima JP, Monteiro F, Josahkian J, Lesca G, Chatron N, Ville D, Murphy D, Neul JL, Mullegama SV, Begtrup A, Herman I, Mitani T, Posey JE, Tay CG, Javed I, Carr L, Kanani F, Beecroft F, Hane L, Abdelkreem E, Macek M, Bispo L, Elmaksoud MA, Hashemi-Gorji F, Pehlivan D, Amor DJ, Jamra RA, Chung WK, Ghayoor EK, Campeau P, Alkuraya FS, Pagnamenta AT, Gleeson J, Lupski JR, Striano P, Moreno-De-Luca A, Lafontaine DLJ, Houlden H, Maroofian R. Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders. Genet Med. 2024 Sep 10:101251. doi: 10.1016/j.gim.2024.101251. Epub ahead of print. PMID: 39275948.
Multivalency drives interactions of alpha-synuclein fibrils with tau
Ramirez J, Saleh IG, Yanagawa ESK, Shimogawa M, Brackhahn E, Petersson EJ, Rhoades E. Multivalency drives interactions of alpha-synuclein fibrils with tau. PLoS One. 2024 Sep 10;19(9):e0309416. doi: 10.1371/journal.pone.0309416. PMID: 39255305; PMCID: PMC11386428.
Single-Molecule Studies of Cognate and Near-Cognate Elongation in an in vitro Eukaryotic Translation System
Fritsch C, Bhattacharya A, Ng MY, Li H, Nelson PC, Cooperman BS, Goldman YE. Single-Molecule Studies of Cognate and Near-Cognate Elongation in an in vitro Eukaryotic Translation System. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.609187. doi: 10.1101/2024.08.29.609187. PMID: 39257735; PMCID: PMC11383654.
The central spindle drives anaphase chromosome segregation
Chen GY, Deng C, Chenoweth DM, Lampson MA. The central spindle drives anaphase chromosome segregation. bioRxiv [Preprint]. 2024 Aug 30:2024.08.30.610502. doi: 10.1101/2024.08.30.610502. PMID: 39257822; PMCID: PMC11383980.
Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development
Leahy TP, Chenna SS, Soslowsky LJ, Dyment NA. Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development. FASEB J. 2024 Sep;38(17):e70050. doi: 10.1096/fj.202400151R. PMID: 39259535.
Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks
Xu M, Rutkowski DM, Rebowski G, Boczkowska M, Pollard LW, Dominguez R, Vavylonis D, Ostap EM. Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks. Sci Adv. 2024 Sep 13;10(37):eado5788. doi: 10.1126/sciadv.ado5788. Epub 2024 Sep 13. PMID: 39270022; PMCID: PMC11397503.
Chronic Activation of Tubulin Tyrosination Improves Heart Function
Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herrera-Rivero M, Siebels B, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo M, Lindner D, Prosser BL, Carrier L. Chronic Activation of Tubulin Tyrosination Improves Heart Function. Circ Res. 2024 Sep 16. doi: 10.1161/CIRCRESAHA.124.324387. Epub ahead of print. PMID: 39279670.
