Publications

See below for the latest publications by PMI members and their labs.

April 18, 2025
Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation
Paul A. Janmey, Ph.D.
Yuan Z, Janmey PA, McCulloch CA. Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation. Cell Commun Signal. 2025 Apr 18;23(1):187. doi: 10.1186/s12964-025-02194-z. PMID: 40251523; PMCID: PMC12007377.
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April 16, 2025
Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage
John W.  Weisel, Ph.D.
Peshkova AD, Rednikova EK, Khismatullin RR, Kim OV, Muzykantov VR, Purohit PK, Litvinov RI, Weisel JW. Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage. Blood Adv. 2025 Apr 16:bloodadvances.2024015533. doi: 10.1182/bloodadvances.2024015533. Epub ahead of print. PMID: 40238947.
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April 15, 2025
Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction
Daniel P. Kelly, M.D.
Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, Kelly DP. Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction. ESC Heart Fail. 2025 Apr 15. doi: 10.1002/ehf2.15285. Epub ahead of print. PMID: 40232999.
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April 7, 2025
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Zolt Arany, M.D., Sharlene M. Day, MD
Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P; Penn Medicine Biobank; Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM. Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. Nat Genet. 2025 Apr;57(4):829-838. doi: 10.1038/s41588-025-02140-2. Epub 2025 Apr 7. PMID: 40195560.
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April 1, 2025
Long range mutual activation establishes Rho and Rac polarity during cell migration
Janis K. Burkhardt, Ph.D.
De Belly H, Gallen AF, Strickland E, Estrada DC, Zager PJ, Burkhardt JK, Turlier H, Weiner OD. Long range mutual activation establishes Rho and Rac polarity during cell migration. bioRxiv [Preprint]. 2024 Oct 2:2024.10.01.616161. doi: 10.1101/2024.10.01.616161. PMID: 40236007; PMCID: PMC11996577.
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March 30, 2025
A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Tatyana M. Svitkina, Ph.D
Iu E, Bogatch A, Deng W, Humphries JD, Yang C, Valencia FR, Li C, McCulloch CA, Tanentzapf G, Svitkina TM, Humphries MJ, Plotnikov SV. A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration. bioRxiv [Preprint]. 2025 Mar 30:2025.03.28.646012. doi: 10.1101/2025.03.28.646012. PMID: 40196692; PMCID: PMC11974816.
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March 26, 2025
Poroelasticity and permeability of fibrous polymer networks under compression
Paul A. Janmey, Ph.D.
Mollenkopf P, Kochanowski JA, Ren Y, Vining KH, Janmey PA, Purohit PK. Poroelasticity and permeability of fibrous polymer networks under compression. Soft Matter. 2025 Mar 26;21(13):2400-2412. doi: 10.1039/d4sm01223b. PMID: 39976571; PMCID: PMC11841696.
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March 26, 2025
Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states
E. Michael Ostap, Ph.D., Yale E. Goldman, M.D., Ph.D
Cail RC, Báez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM. Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states. J Biol Chem. 2025 Mar 19;301(5):108412. doi: 10.1016/j.jbc.2025.108412. Epub ahead of print. PMID: 40118457.
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March 19, 2025
Clinical signatures of SYNGAP1-related disorders through data integration
Benjamin L. Prosser, Ph.D
McKee JL, Magielski JH, Xian J, Cohen S, Toib J, Harrison A, Chen C, Kim D, Rathod A, Brimble E, Fitter N, Graglia JM, Helde KA, McKeown Ruggiero S, Boland MJ, Prosser BL, Sederman R, Helbig I. Clinical signatures of SYNGAP1-related disorders through data integration. Genet Med. 2025 Mar 19:101419. doi: 10.1016/j.gim.2025.101419. Epub ahead of print. PMID: 40119723.
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March 13, 2025
Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch
Ekaterina Grishchuk, Ph.D.
Demidov VM, Gonchar IV, Tripathy SK, Ataullakhanov FI, Grishchuk EL. Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch. bioRxiv [Preprint]. 2025 Mar 13:2025.03.13.643154. doi: 10.1101/2025.03.13.643154. PMID: 40161670; PMCID: PMC11952512.
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