Publications

See below for the latest publications by PMI members and their labs.

January 10, 2022
CAR T cells produced in vivo to treat cardiac injury.
Jonathan A. Epstein, M.D.
Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, Li L, Kimura T, Soliman OY, Papp TE, Tam YK, Mui BL, Albelda SM, Puré E, June CH, Aghajanian H, Weissman D, Parhiz H, Epstein JA. Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6. PMID: 34990237
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December 1, 2021
Nucleation, stabilization, and disassembly of branched actin networks
Roberto Dominguez, Ph.D.
Gautreau AM, Fregoso FE, Simanov G, Dominguez R. Nucleation, stabilization, and disassembly of branched actin networks. Trends Cell Biol. 2021 Nov 23:S0962-8924(21)00208-7. doi: 10.1016/j.tcb.2021.10.006. Epub ahead of print. PMID: 34836783.
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November 30, 2021
Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis
Dennis E. Discher, Ph.D., Rebecca G. Wells, M.D
Vashisth M, Cho S, Irianto J, Xia Y, Wang M, Hayes B, Wieland D, Wells R, Jafarpour F, Liu A, Discher DE. Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2112940118. doi: 10.1073/pnas.2112940118. PMID: 34810266.
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November 19, 2021
AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology
Zolt Arany, M.D., Paul M. Titchenell, Ph.D., Tejvir S. Khurana, M.D., Ph.D.
Jaiswal N, Gavin M, Loro E, Sostre-Colón J, Roberson PA, Uehara K, Rivera-Fuentes N, Neinast M, Arany Z, Kimball SR, Khurana TS, Titchenell PM. AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology. J Cachexia Sarcopenia Muscle. 2021 Nov 9. doi: 10.1002/jcsm.12846. Epub ahead of print. PMID: 34751006.
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November 16, 2021
Programmable and contractile materials through cell encapsulation in fibrous hydrogel assemblies
Vivek B. Shenoy, Ph.D., Paul A. Janmey, Ph.D.
Davidson MD, Prendergast ME, Ban E, Xu KL, Mickel G, Mensah P, Dhand A, Janmey PA, Shenoy VB, Burdick JA. Programmable and contractile materials through cell encapsulation in fibrous hydrogel assemblies. Sci Adv. 2021 Nov 12;7(46):eabi8157. doi: 10.1126/sciadv.abi8157. Epub 2021 Nov 10. PMID: 34757787.
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November 11, 2021
Truncated titin proteins in dilated cardiomyopathy
Zolt Arany, M.D.
McAfee, Quentin, Christina Yingxian Chen, Yifan Yang, Matthew A. Caporizzo, Michael Morley, Apoorva Babu, Sunhye Jeong et al. "Truncated titin proteins in dilated cardiomyopathy." Science Translational Medicine 13, no. 618 (2021): eabd7287.
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November 3, 2021
Physics and Physiology of Cell Spreading in Two and Three Dimensions
Paul A. Janmey, Ph.D.
Janmey PA, Hinz B, McCulloch CA. Physics and Physiology of Cell Spreading in Two and Three Dimensions. Physiology (Bethesda). 2021 Nov 1;36(6):382-391. doi: 10.1152/physiol.00020.2021. PMID: 34704856.
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November 1, 2021
Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites
E. Michael Ostap, Ph.D., Erika L. F. Holzbaur, Ph.D., Melike Lakadamyali, Ph.D.
Masucci EM, Relich PK, Lakadamyali M, Ostap EM, Holzbaur ELF. Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites. Mol Biol Cell. 2021 Oct 27:mbcE21100480. doi: 10.1091/mbc.E21-10-0480. Epub ahead of print. PMID: 34705476.
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October 26, 2021
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis
Patrick Seale, Ph.D.
Stefkovich M, Traynor S, Cheng L, Merrick D, Seale P. Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis. Mol Metab. 2021 Oct 15:101357. doi: 10.1016/j.molmet.2021.101357. Epub ahead of print. PMID: 34662714.
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October 21, 2021
A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells
Melike Lakadamyali, Ph.D.
Martin L, Vicario C, Castells-García Á, Lakadamyali M, Neguembor MV, Cosma MP. A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells. STAR Protoc. 2021 Sep 30;2(4):100865. doi: 10.1016/j.xpro.2021.100865. PMID: 34632419; PMCID: PMC8488755.
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