Explore our vibrant Muscle Biology and Muscle Disease training program, supported in part by a T32 award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. 

The development of new technologies, motivated by significant biological problems is a major emphasis of PMI.

Members of the Pennsylvania Muscle Institute are using and developing state-of-the-art techniques to understand the molecular events required for the regulation of cell migration and intracellular transport.

Members of the PMI are investigating the mechanisms cardiac, skeletal, and smooth muscle contraction and regulation.  They are discovering the fundamental science of contractility, and they are investigating the molecular basis of a range of muscle diseases.

PMI members are determining the mechanisms by which cytoskeletal motors power motility, transport, and contraction at the atomic to cellular levels.

PMI members are investigating how the cytoskeletal and cell cycle are coordinated to ensure the equal partitioning of genetic information.

PMI members investigate several muscle-based pathologies, including muscular dystrophy, inherited cardiomyopathies, and other neuromuscular diseases.

PMI members are using a multidisciplinary approach to discover important steps and mechanisms in muscle development and homeostasis in normal and diseased models.