Members

PMI membership consists of an extraordinarily strong interdisciplinary team of scientists that investigate muscle biology and non-muscle contractile systems. Specifically, our members use biophysics, biochemistry, genetics, physiology and ultrastructure to understand cell migration and intracellular transport, molecular motors, cell division, muscle contraction and development, muscle pathologies and therapies targeted to muscle disease.

Charles S. Abrams, M.D.
Department of Medicine, University of Pennsylvania

Phospholipid Signaling in Platelet and T-cells

Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Zolt Arany, M.D.
Department of Medicine, University of Pennsylvania

Cardiovascular Metabolism

Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Yair Argon Ph.D
Pathology Division: Cell Pathology, Children's Hospital of Philadelphia

Control of IGF signaling in muscle

Muscle Signaling & Metabolism
Richard K. Assoian, Ph.D
Department of Pharmacology, University of Pennsylvania

Cell adhesion and mechanotransduction in smooth muscle cells and cardiovascular biology

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Joseph A. Baur, Ph.D.
Department of Physiology, University of Pennsylvania

Metabolic and signaling pathways by which nutrient intake can influence longevity, with a particular emphasis on NAD and mTOR

Muscle Signaling & Metabolism
Stephen M. Baylor, M.D.
Department of Physiology, University of Pennsylvania

Professor Emeritus, E-C coupling in skeletal muscle

Mechanism & Regulation of Muscle Contraction
Muscle Signaling & Metabolism
Erfei Bi, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Mechanisms of Cell Polarization, Cytokinesis, and Septin Assembly and Function

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Chromosome Segregation & Cell Division
Joel D. Boerckel, Ph.D.
Department of Orthopaedic Surgery and Bioengineering, University of Pennsylvania

Mechanobiology of development and regeneration

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Janis K. Burkhardt, Ph.D.
Department of Pathology & Laboratory Medicine, University of Pennsylvania

Role of the cytoskeleton in T cell function

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Yi-Wei Chang, Ph.D.
Department of Biochemistry and Biophysics , University of Pennsylvania

In situ structural biology, cryo-electron tomography

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Margaret M. Chou, M.D
Cell and Developmental Biology, University of Pennsylvania

G-Protein & cell transformations

Tissue & Cell Structure, Cell Migration, & Intracellular Transport
John C. Crocker, Ph.D.
Department of Chemical and Biomolecular Engineering, University of Pennsylvania

Mechanical response of cells to applied mechanical stress

Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Dennis E. Discher, Ph.D.
Chemical/Biomolecular Engineering and Bioengineering, University of Pennsylvania

Cell and molecular mechanics

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Roberto Dominguez, Ph.D.
Department of Physiology, Perelman School of Medicine, University of Pennsylvania

William Maul Measey Presidential Professor of Physiology, Structural Biology and Biochemistry, the Cytoskeleton and the Link Between the Cytoskeleton, Membranes and Signaling

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Jonathan A. Epstein, M.D.
Department of Medicine, University of Pennsylvania

Heart and Muscle Development

Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Alan W. Flake, M.D., FACS, FAAP
Center for Fetal Diagnosis and Treatment, Surgery, Children's Hospital of Philadelphia

Stem cell and gene therapy

Muscle Pathologies & Therapies
Clara Franzini-Armstrong, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Ultrastructure of striated muscle

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Yale E. Goldman, M.D., Ph.D
Department of Physiology, University of Pennsylvania

Relating the structural changes to enzymatic reactions & mechanical steps of the energy transduction mechanism by mapping the motions of proteins & ribosomal elongation factors

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Advanced Technological Development
Matthew C. Good, Ph.D.
Department of Cell and Developmental Biology, Department of Bioengineering, University of Pennsylvania

Size scaling, spatial organization of cells, cytoskeleton, signaling

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Michael Granato, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Axonal Guidance, axonal de-and-regeneration, motor behavior regulation

Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Ekaterina Grishchuk, Ph.D.
Department of Physiology, University of Pennsylvania

Biophysics of cell division

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Chromosome Segregation & Cell Division
Advanced Technological Development
Wei Guo, Ph.D
Department of Biology, University of Pennsylvania

Molecular basis of polarized exocytosis

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Erika L. F. Holzbaur, Ph.D.
Department of Physiology, University of Pennsylvania

Microtubule-based molecular motors

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Muscle Signaling & Metabolism
Christopher J. Janetopoulos, Ph.D.
Department of Biological Sciences, University of the Sciences in Philadelphia

Regulation of Cell Polarity during Migration and Cytokinesis

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Paul A. Janmey, Ph.D.
Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania

Cytoskeletal mechanics and signaling

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Roland G. Kallen, M.D., Ph.D.
Biochemistry & Biophysics, University of Pennsylvania

Molecular Characterization of Ion Channels

Muscle Signaling & Metabolism
Anna S. Kashina, Ph.D.
Department of Animal Biology, University of Pennsylvania

Physiological role of protein arginylation

Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Muscle Development & Myofibril Assembly
Alan M. Kelly, B.Sc., B.V.Sc., Ph.D.
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania

Development of neuromuscular specialization

Muscle Signaling & Metabolism
Daniel P. Kelly, M.D.
Medicine/Cardiovascular Institute, University of Pennsylvania

Ware Professor of Medicine and Director Cardiovascular Institute, Control of Striated Muscle Mitochondrial Energy Metabolism in Health and Disease

Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Tejvir S. Khurana, M.D., Ph.D.
Department of Physiology, University of Pennsylvania

Neuromuscular disease and gene therapy

Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Melike Lakadamyali, Ph.D.
Department of Physiology & the Department of Cell & Developmental Biology, University of Pennsylvania

Regulation of microtubule cytoskeleton architecture and intracellular trafficking, nuclear architecture and nuclear function, and super-resolution microscopy

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Michael Lampson, Ph.D.
Department of Biology, University of Pennsylvania

Chromosome segregation and cell division

Chromosome Segregation & Cell Division
Advanced Technological Development
Virginia Man-Yee Lee, Ph.D
Department of Pathology and Laboratory Medicine, University of Pennsylvania

Pathogenesis of misfolded neurodegenerative disease proteins

Muscle Pathologies & Therapies
Muscle Signaling & Metabolism
Jon Martin Lindstrom, Ph.D
Neuroscience, University of Pennsylvania

Nicotinic Acelytcholine Receptors

Muscle Signaling & Metabolism
Francis Luca, Ph.D.
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania

Cell cycle, mitosis, cytokinesis

Chromosome Segregation & Cell Division
Kenneth B. Margulies, M.D.
Department of Medicine, Cardiovascular Division, Physiology, Cardiovascular Institute, University of Pennsylvania

Cardiac mechanobiology, regulation of contractility, translational heart failure and transplant research

Mechanism & Regulation of Muscle Contraction
Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Michael S. Marks, Ph.D.
Department of Pathology & Laboratory Medicine, CHOP; Dept. of Pathology & Laboratory Medicine and Department of Physiology, University of Pennsylvania

Regulation and diseases of intracellular membrane transport and lysosome-related organelle biogenesis

Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Robert L. Mauck, Ph.D.
Department of Orthopaedic Surgery, Department of Bioengineering, University of Pennsylvania

Musculoskeletal mechanobiology and tissue engineering

Mechanism & Regulation of Muscle Contraction
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Muscle Pathologies & Therapies
Advanced Technological Development
Foteini Mourkioti, Ph.D.
Department of Orthopaedic Surgery, University of Pennsylvania

Skeletal muscle and cardiac function in normal or diseased conditions

Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Advanced Technological Development
Vivianne T. Nachmias, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Regulation and control of the cytoskeleton

Structure & Function Studies of Cytoskeletal Proteins
E. Michael Ostap, Ph.D.
Department of Physiology, University of Pennsylvania

Director of Pennsylvania Muscle Institute, Biochemistry and cell biology of unconventional myosins

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Muscle Pathologies & Therapies
Advanced Technological Development
Shae Padrick, Ph.D.
Department of Biochemistry and Molecular Biology, Drexel University

Regulation of cytoskeletal dynamics

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Michael S. Parmacek, M.D
Division of Cardiovascular Medicine, School of Medicine, University of Pennsylvania

Muscle-specific gene expression

Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Benjamin L. Prosser, Ph.D
Department of Physiology, University of Pennsylvania

Cardiac mechanobiology, neurodevelopmental disorders

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Advanced Technological Development
Ionas Pyrpassopoulos, Ph.D.
Department of Physiology, University of Pennsylvania

Biophysics of cytoskeletal motors

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Elizabeth Rhoades, Ph.D.
Department of Chemistry, University of Pennsylvania

Biophysics and biochemistry of intrinsically disordered proteins

Structure & Function Studies of Cytoskeletal Proteins
Advanced Technological Development
Jeffrey Roizen, M.D., Ph.D., FAAP
Department of Pediatrics, University of Pennsylvania, The Children’s Hospital of Philadelphia

Metabolism and action of vitamin D in muscle

Muscle Signaling & Metabolism
Lawrence Rome, Ph.D.
Department of Biology, University of Pennsylvania

Design and function of muscular systems for locomotion and sound production, calcium, redox, and mechano-signaling in heart

Mechanism & Regulation of Muscle Contraction
Muscle Signaling & Metabolism
Neal A. Rubinstein, M.D., Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Control of contractile protein expression

Muscle Development & Myofibril Assembly
Daniel Safer, Ph.D.
Department of Physiology, University of Pennsylvania

Regulation of actin assembly and cell motility

Structure & Function Studies of Cytoskeletal Proteins
Patrick Seale, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Cell and Molecular Biology

Muscle Signaling & Metabolism
Vivek B. Shenoy, Ph.D.
Penn Engineering, University of Pennsylvania

Understand the basic principles that control the behavior of both engineering and biological systems

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Henry Shuman, Ph.D.
Department of Physiology, University of Pennsylvania

Endocytosis, cytoskeleton and biophysics of molecular motors

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Advanced Technological Development
Marion J. Siegman, Ph.D.
Department of Molecular Physiology and Biophysics, Thomas Jefferson University

Remodeling of smooth muscle in disease

Mechanism & Regulation of Muscle Contraction
Muscle Pathologies & Therapies
Muscle Signaling & Metabolism
Louis J. Soslowsky, Ph.D.
Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania

Structure-function relationships & mechanisms of tendon & ligament development, injury, healing; evaluate potential treatment modalities for tendon & ligament injuries

Mechanism & Regulation of Muscle Contraction
Muscle Pathologies & Therapies
Advanced Technological Development
Hansell H. Stedman, M.D.
Department of Surgery, University of Pennsylvania

Gene therapy for inherited muscle diseases

Mechanism & Regulation of Muscle Contraction
Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Tatyana M. Svitkina, Ph.D
Department of Biology, University of Pennsylvania

Mechanisms of cell motility and roles of the cytoskeleton

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
H. Lee Sweeney, Ph.D.
Department of Pharmacology, University of Florida

Contractile protein function, human muscle diseases and gene therapy

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Muscle Pathologies & Therapies
Muscle Development & Myofibril Assembly
Muscle Signaling & Metabolism
Paul M. Titchenell, Ph.D.
Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania

Control of Muscle Metabolism by Insulin

Muscle Signaling & Metabolism
Phong T. Tran, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Microtubule dynamics and cellular pattern formation

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Dimitrios Vavylonis, Ph.D
Department of Physics, Lehigh University

Mathematical modeling in cellular biophysics

Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Chromosome Segregation & Cell Division
Advanced Technological Development
Susan W. Volk, VMD, PhD, Dipl ACVS
School of Veterinary Medicine, University of Pennsylvania

Wound repair and regeneration, extracellular matrix scar formation and fibrosis, regenerative medicine cell-based therapies, & tumor microenvironment

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
John W. Weisel, Ph.D.
Cell and Developmental Biology, University of Pennsylvania

Blood coagulation, fibrinolysis, and atherosclerosis

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
Advanced Technological Development
Rebecca G. Wells, M.D
Department of Medicine (Gastroenterology), University of Pennsylvania

Mechanical and matrix factors in liver fibrosis

Structure & Function Studies of Cytoskeletal Proteins
Tissue & Cell Structure, Cell Migration, & Intracellular Transport
David F. Wilson, Ph.D
Biochemistry & Biophysics, University of Pennsylvania

Integration of metabolism; Oxidative phosphorylation; Neuroregulation

Muscle Signaling & Metabolism
Tim J. Yen, Ph.D.
Cellular and Developmental Biology, Fox Chase Cancer Center

Structure and function of mammalian centromeres and kinetochores

Chromosome Segregation & Cell Division
Christopher M. Yengo, Ph.D.
Cellular and Molecular Physiology, Penn State Milton S. Hershey Medical Center

Structural mechanism of force generation in myosin, genetic mutations associated with heart disease and deafness, physiological mechanisms of contractile dysfunction

Mechanism & Regulation of Muscle Contraction
Structure & Function Studies of Cytoskeletal Proteins
Muscle Pathologies & Therapies
Zarazuela Zolkipli-Cunningham, MBChB, MRCP
Institution Division of Human Genetics, Children's Hospital of Philadelphia

Mitochondrial myopathy: nanosensor measurement of muscle O2 levels, new therapeutic strategies involving nutrition and exercise, mechanisms of muscle fatigue

Muscle Pathologies & Therapies
Muscle Signaling & Metabolism