Louis J. Soslowsky, Ph.D.

faculty photo
Fairhill Professor
Director of Orthopaedic Research, University of Pennsylvania
Director of Basic Science Research, Shoulder and Elbow Service, University of Pennsylvania
Vice Chair for Research, Department of Orthopaedic Surgery, University of Pennsylvania (reappointed 2009)
Professor, Department of Bioengineering, University of Pennsylvania
Fellow, Institute of Aging, University of Pennsylvania
Founding Director, Penn Center for Musculoskeletal Disorders, University of Pennsylvania (Type 1 center designation in 2008)
Executive Committee, University of Pennsylvania, Department of Bioengineering
Executive Committee, Department of Bioengineering, University of Pennsylvania
Associate Dean for Research Integration, University of Pennsylvania, Perelman School of Medicine
Department: Orthopaedic Surgery
Graduate Group Affiliations

Contact information
McKay Orthopaedic Research Laboratory
307A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8654
Fax: 215-573-2133
East Brunswick High School , 1982.
B.S. (Engineering Mechanics)
Columbia University, 1986.
M.S. (Engineering Mechanics)
Columbia University, 1987.
Columbia University, 1989.
Ph.D. (Engineering Mech./Biomechanics, Mentor: Van C. Mow)
Columbia University, 1991.
Cert. (Academic Medicine Leadership Program)
Wharton School of the University of Pennsylvania , 2008.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

orthopaedic research, orthopaedic biomechanics and tissue engineering, tendons and ligaments, shoulder and elbow

Selected Publications

Beach ZM, Nuss CA, Weiss SN, Soslowsky LJ: Neonatal achilles tendon microstructure is negatively impacted by decorin and biglycan knockdown after injury and during development. Ann Biomed Eng Dec 2023.

Newton JB, Nuss CA, Weiss SN, Betts RL, Soslowsky LJ: Novel application of in vivo microdialysis in a rat achilles tendon acute injury model. J Appl Physiol (1985) Nov 2023.

Carlson JA, Shetye SS, Sun M, Weiss SN, Birk DE, Soslowsky LJ: Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing. J Orthop Res Nov 2023.

Dyment NA, Kuntz AF, Soslowsky LJ: Special issue: Guiding the future of tendon research. J Orthop Res Page: 2081, Oct 2023.

Darrieutort-Laffite C, Beach ZM, Weiss SN, Eekhoff JD, Soslowsky LJ: Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging. J Orthop Res Page: 2287-94, Oct 2023.

Fung AK, Li Y, Wang J, Leahy TP, Shetye S, Liu XS, Soslowsky LJ: Long-Term effects of reproduction and lactation on the rat supraspinatus tendon and proximal humerus. J Biomech Eng Oct 2023.

Leahy TP, Fung AK, Weiss SN, Dyment NA, Soslowsky LJ: Investigating the temporal roles of decorin and biglycan in tendon healing. J Orthop Res Page: 2238-49, Oct 2023.

Little D, Amadio PC, Awad HA, Cone SG, Dyment NA, Fisher MB, Huang AH, Koch DW, Kuntz AF, Madi R, McGilvray K, Schnabel LV, Shetye SS, Thomopoulos S, Zhao C, Soslowsky LJ: Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how). J Orthop Res Page: 2133-62, Oct 2023.

Beach ZM, Fung AK, Weiss SN, Soslowsky LJ: Post-injury tendon mechanics are not affected by tamoxifen treatment. Connect Tissue Res Page: 75-81, Jan 2023.

Leiphart RJ, Weiss SN, DiStefano MS, Mavridis AA, Adams SA, Dyment NA, Soslowsky LJ: Collagen V deficiency during murine tendon healing results in distinct healing outcomes based on knockdown severity. J Biomech Page: 111315, Nov 2022.

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Last updated: 12/19/2023
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