Tejvir S. Khurana, MD, PhD
Professor of Physiology
Department: Physiology
Graduate Group Affiliations
Contact information
Department of Physiology,
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
Office: (215) 898-4116
Fax: (215) 573-2273
Lab: (215) 573-2640
Fax: (215) 573-2273
Lab: (215) 573-2640
Email:
tsk@pennmedicine.upenn.edu
tsk@pennmedicine.upenn.edu
Education:
MBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
Permanent linkMBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
Description of Research Expertise
muscle, muscular disease, muscular dystrophy, therapeutics, gene therapy, extraocular muscle, transcriptome, proteome, genomics, sports medicine, athletic doping, hypoxia, altitude, respiratory, neuromuscular junctions, synapses.Description of Clinical Expertise
High altitude medicineSelected Publications
Loro E, Sengupta K, Bogdanovich S, Whig K, Schultz DC, Huryn DM, Khurana TS: High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy. Sci. Rep. 2020.Loro E, Jang C, Quinn WJ 3rd, Baur JA, Arany ZP, Khurana TS: Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions. Front Physiol 2019.
Song Y, Morales L, Malik AS, Mead AF, Greer CD, Mitchell MA, Petrov MT, Su LT, Choi ME, Rosenblum ST, Lu X, VanBelzen DJ, Krishnankutty RK, Balzer FJ, Loro E, French R, Propert KJ, Zhou S, Kozyak BW, Nghiem PP, Khurana TS, Kornegay JN, Stedman HH: Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models. Nature Med 2019.
Song S, Wen Y, Tong H, Loro E, Gong Y, Liu J, Hong S, Li L, Khurana TS, Chu M, Sun Z: The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism. J Mol Cell Biol 2018.
Lavorato M, Loro E, Debattisti V, Khurana TS, Franzini-Armstrong C: Elongated mitochondrial constrictions and fission in muscle fatigue. J Cell Sci 131, 2018.
Loro E, Bisetto S, Khurana TS: Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA. J Cell Sci 131, 2018.
Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z: Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med 23: 223-234, 2017.
Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S: DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress. Sci Signal 10 (468): eaaf5967, 2017.
Mishra MK, Loro E, Sengupta K, Wilton SD, Khurana TS: Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction. PLoS One 12(10): e0182676, 2017.
Loro E, Wang SH, Schwab RJ, Khurana TS: In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue. J Vis Exp 6: (125), 2017.