Tejvir S. Khurana, MD, PhD
Professor of Physiology
Member, Pennsylvania Muscle Institute
Department: Physiology
Graduate Group Affiliations
Contact information
Department of Physiology,
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
Office: (215) 898-4116
Fax: (215) 573-2273
Lab: (215) 573-2640
Fax: (215) 573-2273
Lab: (215) 573-2640
Email:
tsk@pennmedicine.upenn.edu
tsk@pennmedicine.upenn.edu
Education:
MBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
Permanent linkMBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
Description of Research Expertise
muscle, muscular disease, muscular dystrophy, therapeutics, gene therapy, extraocular muscle, transcriptome, proteome, genomics, sports medicine, athletic doping, hypoxia, altitude, respiratory, neuromuscular junctions, synapses.Description of Clinical Expertise
High altitude medicineSelected Publications
Jaiswal N, Gavin M, Loro E, Sostre-Colón J, Roberson PA, Uehara K, Rivera-Fuentes N, Neinast M, Arany Z, Kimball SR, Khurana TS, Titchenell PM: AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology. J Cachexia Sarcopenia Muscle 13(1): 495-514, 2022.Dohnalová L, Lundgren P, Carty JRE, Goldstein N, Wenski SL, Nanudorn P, Thiengmag S, Huang KP, Litichevskiy L, Descamps HC, Chellappa K, Glassman A, Kessler S, Kim J, Cox TO, Dmitrieva-Posocco O, Wong AC, Allman EL, Ghosh S, Sharma N, Sengupta K, Cornes B, Dean N, Churchill GA, Khurana TS, Sellmyer MA, FitzGerald GA, Patterson AD, Baur JA, Alhadeff AL, Helfrich EJN, Levy M, Betley JN & Thaiss CA. : A microbiome-dependent gut-brain pathway regulates motivation for exercise. Nature 612(7941): 739-747, 2022.
Tichy ED, Ma N, Sidibe D, Loro E, Kocan J, Chen DZ, Khurana TS, Hasty P, Mourkioti F: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening. Cell Rep 11(35(6)): 109098, 2021.
Loro E, Sengupta K, Bogdanovich S, Whig K, Schultz DC, Huryn DM, Khurana TS: High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy. Sci. Rep. 10, 2020.
Yang S, Loro E, Wada S, Kim B, Tseng WJ, Li K, Khurana TS, Arany Z.: Functional effects of muscle PGC-1alpha in aged animals. Skelet Muscle 10(1), 2020.
Sengupta K, Mishra MK, Loro E, Spencer MJ, Pyle AD, Khurana TS: Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells. Mol Ther Nucleic Acids 22: 500-509, 2020.
Sengupta K, Loro E, Khurana TS: PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD). Sci Rep. 10(1), 2020.
Song D, Navalsky BE, Guan W, Ingersoll C, Wang T, Loro E, Eeles L, Matchett KB, Percy MJ, Walsby-Tickle J, McCullagh JSO, Medina RJ, Khurana TS, Bigham AW, Lappin TR, Lee FS: Tibetan PHD2, an allele with loss-of-function properties. Proc Natl Acad Sci U S A. 117(22): 12230-12238, 2020.
Stone RA, Wei W, Sarfare S, McGeehan B, Engelhart KC, Khurana TS, Maguire MG, Iuvone PM, Nickla DL: Visual Image Quality Impacts Circadian Rhythm-Related Gene Expression in Retina and in Choroid: A Potential Mechanism for Ametropias. Invest Ophthalmol Vis Sci 11(61), 2020.
Loro E, Jang C, Quinn WJ 3rd, Baur JA, Arany ZP, Khurana TS: Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions. Front Physiol 2019.