Tejvir S. Khurana, MD, PhD.
Tejvir S. Khurana, MD, PhD.
Professor of Physiology
Department: Physiology
Graduate Group Affiliations
Contact information
Department of Physiology,
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
University of Pennsylvania,
750 Clinical Research Building (CRB),
415 Curie Boulevard,
Philadelphia, PA 19004-6085
Office: (215) 898-4116
Fax: (215) 573-2273
Lab: (215) 573-2640
Fax: (215) 573-2273
Lab: (215) 573-2640
Email:
tsk@mail.med.upenn.edu
tsk@mail.med.upenn.edu
Education:
MBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
Permanent linkMBBS (Medicine)
Delhi University, 1985.
Ph.D. (Neurobiology)
Harvard University, 1992.
Description of Research Expertise
muscle, muscular disease, muscular dystrophy, therapeutics, gene therapy, extraocular muscle, transcriptome, proteome, genomics, sports medicine, athletic doping, hypoxia, altitude, respiratory, neuromuscular junctions, synapses.Description of Clinical Expertise
High altitude medicineSelected Publications
Arsenault PR, Song D, Chung YJ, Khurana TS, Lee FS: The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α Mol Cell Biol 36(18): 2328-43, 2016.Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA: Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab 24(2): 269-82, 2016.
Bird SB, Krajacic P, Sawamoto K, Bunya N, Loro E, Khurana TS.: Pharmacotherapy to protect the neuromuscular junction after acute organophosphorus pesticide poisoning. Ann N Y Acad Sci 1374(1): 86-93, 2016.
Ferretti R, Marques MJ, Khurana TS, Santo Neto H: Expression of calcium-buffering proteins in rat intrinsic laryngeal muscles. Physiol Rep 6: pii: e12409, 2015.
Rooney SI, Loro E, Sarver JJ, Peltz CD, Hast MW, Tseng WJ, Kuntz AF, Liu XS, Khurana TS, Soslowsky LJ.: Exercise protocol induces muscle, tendon, and bone adaptations in the rat shoulder. Muscles Ligaments Tendons J 4(4): 413-419, 2015.
Loro E, Seifert EL, Moffat C, Romero F, Mishra MK, Sun Z, Krajacic P, Anokye-Danso F, Summer RS, Ahima RS, Khurana TS: IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity. Am J Physiol Regul Integr Comp Physiol 309(8): R835-844, 2015.
Pan TC, Zhang RZ, Arita M, Bogdanovich S, Adams SM, Gara SK, Wagener R, Khurana TS, Birk DE,Chu ML: A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16. J Biol Chem Page: 10293-10307, 2014.
Mosqueira M, Baby SM, Lahiri S, Khurana TS.: Ventilatory Chemosensory Drive Is Blunted in the mdx Mouse Model of Duchenne Muscular Dystrophy (DMD). PLoS One 8(7):e69567, 2013.
Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR, Lee FS: Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem 288: 17134-17144, 2013.
Pan TC, Zhang RZ, Markova D, Arita M, Zhang Y, Bogdanovich S, Khurana TS, Bönnemann CG, Birk DE, Chu ML: COL6A3 protein deficiency in mice leads to muscle and tendon defects similar to human collagen VI congenital muscular dystrophy. J Biol Chem 288: 14320-14331, 2013.