The Pennsylvania Muscle Institute:

Cytoskeletal Research @ Penn

The PMI is an interdisciplinary group of research investigators, founded to explore mechanisms of muscle function and muscle disease.

The Pennsylvania Muscle Institute:

Cytoskeletal Research @ Penn

The PMI is an interdisciplinary group of research investigators, founded to explore mechanisms of muscle function and muscle disease.

The Pennsylvania Muscle Institute:

Cytoskeletal Research @ Penn

The PMI is an interdisciplinary group of research investigators, founded to explore mechanisms of muscle function and muscle disease.

Welcome to

The Pennsylvania Muscle Institute

The PMI is an interdisciplinary group of research investigators, founded to explore mechanisms of muscle function and muscle disease. Our progress has led us to broaden our focus to include the exploration of cytoskeletal dynamics and their role in cellular functions including cell motility, intracellular transport, and organelle trafficking. Our institute is dedicated to innovative, collaborative, and cross-disciplinary research, and the application of our discoveries to the treatment of human disease.

Save the date: Dec. 5th – PMI Winter Symposium 2025. Details coming soon!

**Please note: website under renovation – please contact us via email to be added to the email listserv for updates on PMI-sponsored events.**

Events

Cell Motility Journal Club

Nov 12, 2025 @ 12:00pm
Cell Motility Journal Club Fall 2025
Cell Motility Journal Club Fall 2025

Cell Motility Journal Club

Nov 19, 2025 @ 12:00pm
Cell Motility Journal Club Fall 2025
Cell Motility Journal Club Fall 2025

PMI Winter Symposium 2025

Dec 5, 2025 @ 08:30am
Symposia & Other Events Fall 2025
Symposia & Other Events Fall 2025

PMI Holiday Party 2025

Dec 12, 2025 @ 03:00pm
PMI Special Events Fall 2025
PMI Special Events Fall 2025

Cell Motility Journal Club

Dec 17, 2025 @ 12:00pm
Cell Motility Journal Club Fall 2025
Cell Motility Journal Club Fall 2025
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Publications

Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity

2025

Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression

2025

Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis

2025

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

2025
View All Publications

News

Please read: PMI Events and Listservs

Please see for more information on PMI event updates.

2025

Save the date – PMI Winter Symposium 2025

Save the date for our PMI Winter Symposium – Fri. Dec. 5, 2025.

More details to come — make sure you are on the PMI Seminars/events listserv to receive info for registration,

2025

Save the date for annual PMI Holiday Party

Save the date – Fri. 12/12 – for the annual PMI Holiday Party! More details to come.

2025

Announcing the appointment of Zoltan Arany, MD, PhD, as Chair of the Department of Physiology

“We are pleased to announce the appointment of Zoltan (Zolt) Arany, MD, PhD, as Chair of the Department of Physiology in the Perelman School of Medicine at the University of Pennsylvania,

2025

Appointment of E. Michael Ostap, PhD, as Senior Vice Dean and Chief Scientific Officer (PSOM)

“Having served in this role as interim since April 2024, Dr. Ostap will continue to oversee all aspects of research and research training, including our nationally recognized Biomedical Graduate Studies,

2025
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