Foteini Mourkioti, PhD

faculty photo
Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Graduate Group Affiliations

Contact information
McKay Orthopaedic Research Laboratory
112A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
Education:
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
Permanent link
 
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Description of Research Expertise

Keywords: muscle disorders, telomeres, NF-kB signaling, muscle regeneration, stem cells, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L.: Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. Proc Natl Acad Sci U S A. 115(39): E9182-E9191, September 2018.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L. : Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. Proc Natl Acad Sci USA September 2018 Notes: published ahead of print September 4. https://doi.org/10.1073/pnas.1808648115.

Elisia D Tichy,David K. Sidibe,Christopher D. Greer,Nicholas M. Oyster,Panteleimon Rompolas,Nadia A. Rosentha, Helen M. Blau and Foteini Mourkioti: A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors in muscle stem cells. Skeletal Muscle 8, September 2018 Notes: doi: 10.1186/s13395-018-0169-7.

Tichy, E.D., Sidibe, D.K., Tierney, M.T., Stec, M.J., Sharifi-Sanjani, M., Hosalkar, H., Mubarak, S., Johnson, F.B., Sacco, A., Mourkioti, F.: Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles Stem Cell Reports Sept 2017 Notes: This paper was highlighted in Penn Medicine News at: https://www.pennmedicine.org/news/news-releases/2017/september/researchers-find-shortened-telomeres-linked-to-dysfunction-in-duchenne-muscular-dystrophy.

Sharifi-Sanjani. M., Oyster, N.M., Tichy, E.D., Bedi, K.C., Harel, O., Margulies, K.B., Mourkioti, F.: Cardiomyocyte-specific telomere shortening is a distinct signature of heart failure in humans Journal of American Heart Association 7(6): 1855-1870, Sept 2017 Notes: This work was highlighted in Penn Medicine News at: https://www.pennmedicine.org/news/news-releases/2017/september/penn-researchers-closer-to-uncovering-a-new-feature-in-heart-failure

Sharifi-Sanjani M, Meeker AK, Mourkioti F.: Evaluation of Telomere Length in Human Cardiac Tissues Using Cardiac Quantitative FISH. Nature Protocols 12: 1855-1870, Aug 2017 Notes: Published online 17 Aug 2017, doi:10.1038/nprot.2017.082.

Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D.: Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. Journal of Clinical Investigation 127(5): 1683-1688, May 2017 Notes: doi: 10.1172/JCI90338.

Tichy, E., Mourkioti, F.: A new method to genotype mdx4cv mice by PCR-RFLP analysis. Muscle & Nerve Jan 2017 Notes: doi: 10.1002/mus.25566. [Epub ahead of print]

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA.: Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metabolism 24(2): 269-82. Aug 2016.

Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM.: Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine 20(3): 255-64. Feb 2014.

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Last updated: 01/07/2019
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