Mauck Laboratory

Welcome to Mauck Laboratory

The goals of our research program in soft tissue mechanobiology and tissue engineering are to understand the physiologic and patho-physiologic processes that regulate the formation, maturation, and adult function of soft connective tissues.  We believe that such an understanding will better direct our efforts to generate functional tissue replacements with a particular focus on articular cartilage and the knee meniscus. Our program utilizes various mechanical and biological testing modalities, scaffold fabrication techniques, and bioreactor culture conditions to explore these issues in both animal and human model systems. Specific information about current work in the Mauck Lab can be found by visiting the Ongoing Research Projects page.

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What's New

Congratulations to Dr. Sarah Gullbrand and Coauthors on European Cells and Materials Publication
April 23, 2024
Congratulations to Dr. Gullbrand and coauthors on their publication in European Cells and Materials. The study, entitled "Intervertebral Disc Degeneration Instigates Vertebral Endplate Remodeling and Facet Joint Pathology in a Large Animal Model," characterizes the degenerative changes that occur across all substructures of the spine following induction of intervertebral disc degeneration in an initially healthy spine using chondroitinase ABC.

Congratulations to Dr. Ana Peredo and Coauthors for New STM Cover
November 15, 2023
Congratulations to Dr. Ana Peredo and coauthors on their latest publication "Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model." Their work was also featured as the cover of Science Translational Medicine's latest issue!

Congratulations to Dr. Kevin Burt, Dr. Natalie Fogarty, and Dr. Elisabeth Lemmon
February 15, 2023
Congratulations to Dr. Kevin Burt, Dr. Natalie Fogarty, and Dr. Elisabeth Lemmon on their poster awards at the Orthopaedic Research Society 2023 Conference. Kevin received a poster award from the Spine Research Section. Natalie and Beth received poster awards from the Meniscus Research Section. See all the talks and posters presented @MauckLab on Twitter!

The Mauck-Gullbrand Spine Group Presents at PSRS 2022
November 09, 2022
Members of the Mauck-Gullbrand Spine group presented to the international spine community at ORS PSRS 2022, and enjoyed reconnecting with our colleagues for the first time since the Covid-19 pandemic. Our clinical collaborator, Dr. Harvey Smith, gave a podium talk highlighting the thesis work of former PhD student Dr. Ana Peredo translating the use of tension-activated annular repair patches in a goat cervical model. Other members of the group presented on structure-function relationships between the disc, endplate, and facet joints in a rabbit disc injury model (Brianna Orozco), the translation of total tissue-engineered disc replacements in a goat cervical model (Dr. Sarah Gullbrand), and the use of hydroxyapatite coating to induce discrete areas of bone formation in composite tissues (Matthew Fainor). Collaborative work developing an injectable granular hydrogel for NP repair with Dr. Victoria Muir and an annular repair patch with Zurimed were also presented by Brianna Orozco and Dr. Sarah Gullbrand, respectively.

Congratulations to Hannah and Coauthors for their paper in Biofabrication.
July 30, 2022
Congratulations to Hannah and Coauthors for their paper "Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model" published in Biofabrication.

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