Stem Cell Mechanobiology and Differentiation
R01 AR071399 NIH/NIAMS
Dual PIs: Eileen Shore and Robert Mauck
Title: Mechanobiology of Progenitor Cells in Heterotopic Ossification
Time Period: 7/1/18-5/31/23
The major goal of this project is to determine how the R206H mutation in the ACVR1/ALK2 receptor alters progenitor cell mechanobiology resulting in aberrant differentiation and matrix ‘read/write’ errors during muscle repair that ultimately culminate in an impaired muscle healing response and the formation of disabling heterotopic bone in fibrodysplasia ossificans progressiva (FOP).
R01 AR075418 NIH/NIAMS
Dual PIs: Robert Mauck and Eiki Koyama
Title: Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing Meniscus
Time Period: 4/1/19-3/31/24
This proposal uses a series of novel mouse models and micro-scale experimental techniques to investigate the origin and track the fate and function of cells that comprise the mature meniscus. We will also define the time-evolving structural and mechanical features of the developing matrix, and query the role of joint loading and cellular response to mechanical inputs in this developmental paradigm.