Translational Models of Tissue Repair and Regeneration
VA RR&D I01 RX001321
PI: Robert Mauck
Title: Bioactive Injectable Implants for Functional Intervertebral Disc Regeneration
Time Period: 08/01/14 – 07/31/23
The major goal of this project is to develop a hydrogel-based therapeutic for restoration of disc function in early stages disc degeneration. The project involves the development of a large animal model of disc degeneration (in the goat), followed by injection of stem cells using a hydrogel carrier. The hydrogel in this instance is a gelatin, chitosan, teleostan mixture that gels upon mixing. The proposal also includes delivery of agents that quell the inflammatory response. Major outcomes are disc biology, biochemistry, and mechanics with different treatment combinations.
VA RR&D I01 RX000174
Dual PIs: Robert Mauck and John Esterhai
Title: Engineered Multi-Functional Nanofibrous Meniscus Implants
Time Period: 02/01/10-12/31/19
The major goal of this project is to generate drug delivering anatomic nanofiber-based meniscus implants.
VA RR&D I01 RX002274
PIs: Robert Mauck and Harvey Smith
Title: Tissue Engineered Total Disc Replacement in a Large Animal Model
Time Period: 04/01/17-3/31/21
The major goal of this project is to evaluate the functional restoration of intervertebral disc function in the cervical spine after replacement with a tissue engineered total disc replacement in a large animal (goat model).
OREF Resident Clinical Scientist Grant
PI: Liane Miller
Title: A Novel Tissue Engineered Anatomic Joint Replacement for TMC Arthritis
Time Period: 10/01/18-09/30/19
This award is to support a resident working with Dr. Mauck (Liane Miller). The project is focused on developing an anatomic tissue engineered trapezio-metacarpal joint for implantation in a minipig model.