Mauck Laboratory

Tissue Mechanics, Biomaterials, and Tissue Engineering

R01 EB002425 NIH/NIBIB

Dual PIs: Dawn Elliott and Robert Mauck
Title: Multi-scale biomechanics of engineered and native fibrous load-bearing tissue
Time Period: 8/1/08-3/31/19

Meniscus architecture viewed under polarized light
Morphology of Proteoglycan rich microdomain within a heterogeneous tissue-engineered construct

The major goals of this project are to study and model the role of proteoglycan-rich inclusions on the micromechanical properties and signal transduction in native and engineered fibrous tissues.

R01 EB008722 NIH/NIBIB

Dual PIs: Jason Burdick and Robert Mauck
Title: Engineering Developmental Microenvironments: Cartilage Formation and Maturation
Time Period: 4/13/09-3/31/19

Engineered cartilage constructs
Engineered cartilage constructs


Focal defect in minipig cartilage imaged by microCT
Focal defect in minipig cartilage imaged by microCT 


Matrix deposition via FUNCAT



The major goal of this project is to optimize the use of customized hyaluronic acid hydrogels to control in vitro and in vivo cartilage formation using adult human mesenchymal stem cells.

R01 AR056624 NIH/NIAMS

Dual PIs: Robert Mauck and Jason Burdick
Title: Dynamic Fibrous Scaffolds for Repairing Dense Connective Tissues
Time Period: 7/1/08-8/31/19

Dynamic fibrous scaffold undergoing dissolution of green fiber fraction.
3D confocal reconstructions of cell migration through aligned or non-aligned nanofibrous networks with and without TSA treatment


The major goal of this project is to develop novel photo-crosslinkable nanofibrous composites with varying mechanics and degradation profiles to delivery agents that influence cell mechanics so as to expedite the repair of the meniscus and other dense fiber-reinforced tissues.

R01 AR071340 NIH/NIAMS

PIs: George Dodge, Daeyeon Lee, and Robert Mauck
Title: Tunable Mechano-Activated Microcapsules for Therapeutic Delivery
Time Period: 9/21/17-8/31/21          


The major goal of this project is to further the development of mechanically activated microcapsules (MAMCs) as a novel controlled drug-delivery system that releases biofactors in response to specific mechanical inputs. In this work, we tune and model mechanical activation through material selection and microcapsule design, with the goal of enabling in vivo delivery in the context of physiologic and clinically relevant loading modalities (e.g., walking, running, therapeutic passive motion during rehabilitation).



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