Welcome to the Grishchuk Lab
Our goal is to understand the molecular mechanisms that produce force and accuracy for mitotic chromosome motions during cell division. We use biophysical, cell biological and computational approaches to study kinetochore proteins, which function as efficient nanomachines: they can capture the energy from microtubule disassembly and provide lasting attachments between the chromosomes and dynamic microtubule ends. There are no man-made or natural macro-devices that function analogously to these couplers, so understanding their principle mechanisms presents a significant challenge. Rigorous understanding of how microtubules attach to chromosomal kinetochores should ultimately assist developing novel and more specific anticancer drugs.
Current and past support for our work comes from
National Science Foundation
Charles E. Kaufman Foundation of The Pittsburgh Foundation
National Institutes of General Medical Sciences, NIH
The Sidney Kimmel Foundation for Cancer Research
The American Cancer Society
Pennsylvania Muscle Institute
Nano-Bio Interface Center, University of Pennsylvania
McCabe Fund, University of Pennsylvania
● Mitotic spindle: From living and synthetic systems to theory
24 – 27 March 2019 | Split, Croatia
● 4th Chesapeake Bay Area Single Molecule Biology Meeting
10 November 2018 | Washington, DC
Our lab presented two posters by Wangxi Luo, PhD and Ivan Gonchar.
● The Structure, Function and Evolution of Centromeres | Gordon Research Conference
29 July – 3 August 2018 | Mount Snow, VT
● Department of Physiology Retreat
8 June 2018 | Merion Tribute House, PA
Volodya Demidov was selected to present his work “Ultrafast force-clamp spectroscopy reveals “sliding” catch-bond behavior of the microtubule binding NDC80 protein”.
● Congratulations to Katya Tarasovetc and her co-authors for publishing their new paper in Biophysical Journal. See featured video here. Well done!
● Congratulations to Katya Tarasovetc for successfully passing her comprehensive exam (May 2018). Good job, Katya!
● The 2018 Mid-Atlantic Mitosis and Meiosis Meeting
2 – 3 April 2018 | Johns Hopkins University, Baltimore, MD
Katya Grishchuk gave a keynote lecture “Chromosomes on the edge: coupling kinetochores to dynamic microtubule ends”.
● 62nd Annual Meeting of the Biophysical Society
17 – 21 February 2018 | San Francisco, CA
Congratulations to Volodya Demidov for receiving a travel award. Volodya presented his work at the “Cytoskeletal Assemblies and Dynamics” platform.