Physiology & PMI Seminar

Monday, March 25th @ 3:00pm

*Refreshments @ 2:45pm

Location: CRB Austrian Auditorium (415 Curie Blvd.)

Speaker: Tatyana Polenova, Ph.D., Professor of Chemistry and Biochemistry, University of Delaware

TITLE: “Magnetic Resonance and Integrative Structural Biology of Protein Assemblies”

Dr. Polenova will discuss recent advances in magic angle spinning (MAS) NMR methods for atomic-resolution structural analysis of large biological assemblies. Using examples of distinct systems studied by her lab, kinesin motor domain and TPX2 proteins assembled with polymerized microtubules, cofilin assembled with filamentous actin, and HIV-1 protein assemblies, she will illustrate the unique information revealed by MAS NMR about atomic-level 3D structures, dynamics, and drug binding, inaccessible by other techniques. Dr. Polenova will present developments on studying proteins in mammalian cells with atomic resolution by 19F MAS NMR and dynamic nuclear polarization. She will also discuss the challenges and opportunities for magnetic resonance in integrative structural biology.