Publications

• Glia: the cellular glue that binds circadian rhythms and sleep.
  Sleep. 2025 Mar 11;48(3); Authors: Carvalhas-Almeida C, Sehgal A

• Coordinating the energetic strategy of glia and neurons for memory.
  Trends in neurosciences. 2025 Feb;48(2):93-95 Epub 2025 Jan 22; Authors: Shoenhard H, Sehgal A

• A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism in Drosophila.
  Proceedings of the National Academy of Sciences of the United States of America. 2025 Jan 28;122(4):e2421178122 Epub 2025 Jan 23; Authors: Avila A, Lewandowski AS, Li Y, Gui J, Lee KA, Yang Z, Kim M, Lyles JT, Man K, Sehgal A, Chandler JD, Zhang SL

• Modulation of RNA processing genes during sleep-dependent memory.
  eLife. 2024 Dec 6;12; Authors: Li Y, Chouhan NS, Zhang SL, Moore RS, Noya SB, Shon J, Yue Z, Sehgal A

• Balancing brain metabolic states during sickness and recovery sleep.
  The European journal of neuroscience. 2024 Dec;60(11):6605-6616 Epub 2024 Nov 14; Authors: Noya SB, Sengupta A, Yue Z, Weljie A, Sehgal A

• Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.
  eLife. 2024 Nov 1;12; Authors: Schwarz JE, Mrčela A, Lahens NF, Li Y, Hsu C, Grant GR, Skarke C, Zhang SL, Sehgal A

• Mitochondrial inhibitors reveal roles of specific respiratory chain complexes in CRY-dependent degradation of TIM.
  Scientific reports. 2024 Oct 30;14(1):26051; Authors: Zheng X, Chen D, Zoltowski B, Sehgal A

• Altered Metabolism during the Dark Period in Drosophila Short Sleep Mutants.
  Journal of proteome research. 2024 Sep 6;23(9):3823-3836 Epub 2024 Jun 5; Authors: Malik DM, Rhoades SD, Kain P, Sengupta A, Sehgal A, Weljie AM

• Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle.
  bioRxiv : the preprint server for biology. 2024 Aug 21; Authors: Malik DM, Rhoades SD, Zhang SL, Sengupta A, Barber A, Haynes P, Arnadottir ES, Pack A, Kibbey RG, Kain P, Sehgal A, Weljie AM

• The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila.
  Sleep. 2024 Aug 14;47(8); Authors: O'Hara MK, Saul C, Handa A, Cho B, Zheng X, Sehgal A, Williams JA

• Do metabolic deficits contribute to sleep disruption in monogenic intellectual disability syndromes?
  Trends in neurosciences. 2024 Aug;47(8):583-592 Epub 2024 Jul 24; Authors: Valencia ML, Sofela FA, Jongens TA, Sehgal A

• Author Correction: Senescent glia link mitochondrial dysfunction and lipid accumulation.
  Nature. 2024 Aug;632(8026):E8; Authors: Byrns CN, Perlegos AE, Miller KN, Jin Z, Carranza FR, Manchandra P, Beveridge CH, Randolph CE, Chaluvadi VS, Zhang SL, Srinivasan AR, Bennett FC, Sehgal A, Adams PD, Chopra G, Bonini NM

• Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells.
  Proceedings of the National Academy of Sciences of the United States of America. 2024 Jul 23;121(30):e2319782121 Epub 2024 Jul 15; Authors: Iascone DM, Zhang X, Brafford P, Mesaros C, Sela Y, Hofbauer S, Zhang SL, Madhwal S, Cook K, Pivarshev P, Stanger BZ, Anderson S, Dang CV, Sehgal A

• Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.
  bioRxiv : the preprint server for biology. 2024 Jul 1; Authors: Schwarz JE, Mrčela A, Lahens NF, Li Y, Hsu CT, Grant G, Skarke C, Zhang SL, Sehgal A

• Senescent glia link mitochondrial dysfunction and lipid accumulation.
  Nature. 2024 Jun;630(8016):475-483 Epub 2024 Jun 5; Authors: Byrns CN, Perlegos AE, Miller KN, Jin Z, Carranza FR, Manchandra P, Beveridge CH, Randolph CE, Chaluvadi VS, Zhang SL, Srinivasan AR, Bennett FC, Sehgal A, Adams PD, Chopra G, Bonini NM

• Age-regulated cycling metabolites are relevant for behavior.
  Aging cell. 2024 Apr;23(4):e14082 Epub 2024 Jan 11; Authors: Schwarz JE, Sengupta A, Guevara C, Barber AF, Hsu CT, Zhang SL, Weljie A, Sehgal A

• A neuron-glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis.
  Nature neuroscience. 2024 Apr;27(4):666-678 Epub 2024 Feb 15; Authors: Haynes PR, Pyfrom ES, Li Y, Stein C, Cuddapah VA, Jacobs JA, Yue Z, Sehgal A

• Circadian regulation of lung repair and regeneration.
  JCI insight. 2024 Mar 8;9(5); Authors: Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S

• Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity.
  Nature communications. 2024 Jan 20;15(1):633; Authors: Zhang X, Pant SM, Ritch CC, Tang HY, Shao H, Dweep H, Gong YY, Brooks R, Brafford P, Wolpaw AJ, Lee Y, Weeraratna A, Sehgal A, Herlyn M, Kossenkov A, Speicher D, Sorger PK, Santagata S, Dang CV

• Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells.
  bioRxiv : the preprint server for biology. 2023 Nov 13; Authors: Iascone DM, Zhang X, Bafford P, Mesaros C, Sela Y, Hofbauer S, Zhang SL, Cook K, Pivarshev P, Stanger BZ, Anderson S, Dang CV, Sehgal A

• Altered Metabolism During the Dark Period in Drosophila Short Sleep Mutants.
  bioRxiv : the preprint server for biology. 2023 Nov 2; Authors: Malik DM, Sengupta A, Sehgal A, Weljie AM

• The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila.
  bioRxiv : the preprint server for biology. 2023 Oct 16; Authors: O'Hara MK, Saul C, Handa A, Sehgal A, Williams JA

• Sleepiness, not total sleep amount, increases seizure risk.
  bioRxiv : the preprint server for biology. 2023 Oct 2; Authors: Cuddapah VA, Hsu CT, Li Y, Shah HM, Saul C, Killiany S, Shon J, Yue Z, Gionet G, Putt ME, Sehgal A

• Circadian regulation of lung repair and regeneration.
  JCI insight. 2023 Aug 22;8(16); Authors: Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S

• Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier.
  eLife. 2023 May 4;12; Authors: Li F, Artiushin G, Sehgal A

• Variant-to-gene, gene-to-trait: finding new sleep genes through GWAS.
  Trends in genetics : TIG. 2023 May;39(5):338-339 Epub 2023 Feb 28; Authors: Noya SB, Sehgal A

• Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.
  Current biology : CB. 2023 Apr 24;33(8):1613-1623.e5 Epub 2023 Mar 24; Authors: Bedont JL, Kolesnik A, Pivarshev P, Malik D, Hsu CT, Weljie A, Sehgal A

• The microbiome stabilizes circadian rhythms in the gut.
  Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 31;120(5):e2217532120 Epub 2023 Jan 23; Authors: Zhang Y, Li Y, Barber AF, Noya SB, Williams JA, Li F, Daniel SG, Bittinger K, Fang J, Sehgal A

• Ecdysone acts through cortex glia to regulate sleep in Drosophila.
  eLife. 2023 Jan 31;12; Authors: Li Y, Haynes P, Zhang SL, Yue Z, Sehgal A

• The Kinetics and (Dys)kinetics of Cancer Chronotherapy.
  Cancer research. 2022 Jul 5;82(13):2357-2360; Authors: Field JM, Sehgal A

• Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 May 4;42(18):3856-3867 Epub 2022 Mar 31; Authors: Chouhan NS, Sehgal A

• Circadian Rhythms, Disease and Chronotherapy.
  Journal of biological rhythms. 2021 Dec;36(6):503-531 Epub 2021 Sep 22; Authors: Lee Y, Field JM, Sehgal A

• Hugin(+) neurons provide a link between sleep homeostat and circadian clock neurons.
  Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov 23;118(47); Authors: Schwarz JE, King AN, Hsu CT, Barber AF, Sehgal A

• Short and long sleeping mutants reveal links between sleep and macroautophagy.
  eLife. 2021 Jun 4;10; Authors: Bedont JL, Toda H, Shi M, Park CH, Quake C, Stein C, Kolesnik A, Sehgal A

• Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount.
  Sleep. 2021 May 14;44(5); Authors: Hsu CT, Choi JTY, Sehgal A

• Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain.
  Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 9;118(10); Authors: Barber AF, Fong SY, Kolesnik A, Fetchko M, Sehgal A

• Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates.
  eLife. 2021 Mar 2;10; Authors: Issah Y, Naik A, Tang SY, Forrest K, Brooks TG, Lahens N, Theken KN, Mermigos M, Sehgal A, Worthen GS, FitzGerald GA, Sengupta S

• Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.
  Science advances. 2021 Feb;7(7) Epub 2021 Feb 12; Authors: Lee Y, Fong SY, Shon J, Zhang SL, Brooks R, Lahens NF, Chen D, Dang CV, Field JM, Sehgal A

• The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey.
  Journal of biological rhythms. 2021 Feb;36(1):84-96 Epub 2021 Jan 11; Authors: Sehgal A

• A circadian clock regulates efflux by the blood-brain barrier in mice and human cells.
  Nature communications. 2021 Jan 27;12(1):617; Authors: Zhang SL, Lahens NF, Yue Z, Arnold DM, Pakstis PP, Schwarz JE, Sehgal A

• Monitoring Electrical Activity in Drosophila Circadian Output Neurons.
  Methods in molecular biology (Clifton, N.J.). 2021;2130:221-232; Authors: Barber AF, Sehgal A

• Availability of food determines the need for sleep in memory consolidation.
  Nature. 2021 Jan;589(7843):582-585 Epub 2020 Dec 2; Authors: Chouhan NS, Griffith LC, Haynes P, Sehgal A

• Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System.
  Cell metabolism. 2020 Nov 3;32(5):767-785.e7 Epub 2020 Sep 16; Authors: Li F, Sami A, Noristani HN, Slattery K, Qiu J, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Haynes P, Sehgal A, He Y, Li S, Song Y

• The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.
  Annual review of cell and developmental biology. 2020 Oct 6;36:469-509; Authors: Bedont JL, Iascone DM, Sehgal A

• AANAT1 functions in astrocytes to regulate sleep homeostasis.
  eLife. 2020 Sep 21;9; Authors: Davla S, Artiushin G, Li Y, Chitsaz D, Li S, Sehgal A, van Meyel DJ

• The Glial Perspective on Sleep and Circadian Rhythms.
  Annual review of neuroscience. 2020 Jul 8;43:119-140 Epub 2020 Feb 19; Authors: Artiushin G, Sehgal A

• Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster.
  Cell reports. 2020 Jun 2;31(9):107710; Authors: Jacobs JA, Sehgal A

• Circadian and Sleep Metabolomics Across Species.
  Journal of molecular biology. 2020 May 29;432(12):3578-3610 Epub 2020 May 3; Authors: Malik DM, Paschos GK, Sehgal A, Weljie AM

• RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.
  Journal of biological rhythms. 2020 Feb;35(1):72-83 Epub 2019 Nov 15; Authors: Shakhmantsir I, Dooley SJ, Kishore S, Chen D, Pierce E, Bennett J, Sehgal A

• Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.
  The European journal of neuroscience. 2020 Jan;51(1):268-281 Epub 2018 Aug 16; Authors: King AN, Sehgal A

• Splicing the Clock to Maintain and Entrain Circadian Rhythms.
  Journal of biological rhythms. 2019 Dec;34(6):584-595 Epub 2019 Aug 7; Authors: Shakhmantsir I, Sehgal A

• Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism.
  Cell reports. 2019 Nov 12;29(7):1778-1788.e4; Authors: Hsieh AL, Zheng X, Yue Z, Stine ZE, Mancuso A, Rhoades SD, Brooks R, Weljie AM, Eisenman RN, Sehgal A, Dang CV

• The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation.
  Scientific reports. 2019 Aug 15;9(1):11883; Authors: Lee Y, Shen Y, Francey LJ, Ramanathan C, Sehgal A, Liu AC, Hogenesch JB

• Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep.
  Trends in neurosciences. 2019 Jul;42(7):500-510; Authors: Cuddapah VA, Zhang SL, Sehgal A

• Altered ocular parameters from circadian clock gene disruptions.
  PloS one. 2019;14(6):e0217111 Epub 2019 Jun 18; Authors: Stone RA, McGlinn AM, Chakraborty R, Lee DC, Yang V, Elmasri A, Landis E, Shaffer J, Iuvone PM, Zheng X, Sehgal A, Pardue MT

• G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.
  PLoS biology. 2019 Apr;17(4):e3000228 Epub 2019 Apr 30; Authors: Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A

• A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila.
  Science (New York, N.Y.). 2019 Feb 1;363(6426):509-515; Authors: Toda H, Williams JA, Gulledge M, Sehgal A

• Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila.
  eLife. 2018 Dec 5;7; Authors: Shakhmantsir I, Nayak S, Grant GR, Sehgal A

• Endocytosis at the Drosophila blood-brain barrier as a function for sleep.
  eLife. 2018 Nov 26;7; Authors: Artiushin G, Zhang SL, Tricoire H, Sehgal A

• Circadian and Sleep Circuits Ring Together.
  Neuron. 2018 Nov 7;100(3):514-516; Authors: Hsu CT, Sehgal A

• Asymmetric vasopressin signaling spatially organizes the master circadian clock.
  The Journal of comparative neurology. 2018 Sep 1;526(13):2048-2067 Epub 2018 Aug 22; Authors: Bedont JL, Rohr KE, Bathini A, Hattar S, Blackshaw S, Sehgal A, Evans JA

• Cold Temperatures Fire up Circadian Neurons.
  Cell metabolism. 2018 May 1;27(5):951-953; Authors: Barber AF, Sehgal A

• Wolbachia affects sleep behavior in Drosophila melanogaster.
  Journal of insect physiology. 2018 May-Jun;107:81-88 Epub 2018 Feb 27; Authors: Bi J, Sehgal A, Williams JA, Wang YF

• Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster.
  Journal of biological rhythms. 2018 Apr;33(2):126-136 Epub 2018 Jan 21; Authors: Rhoades SD, Nayak K, Zhang SL, Sehgal A, Weljie AM

• A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
  Cell reports. 2018 Mar 27;22(13):3416-3426; Authors: Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A

• A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux.
  Cell. 2018 Mar 22;173(1):130-139.e10 Epub 2018 Mar 8; Authors: Zhang SL, Yue Z, Arnold DM, Artiushin G, Sehgal A

• Flies come through again, period.
  The Journal of clinical investigation. 2018 Jan 2;128(1):108-109 Epub 2017 Nov 27; Authors: Sehgal A

• Genetic Mechanisms Underlying Sleep.
  Cold Spring Harbor symposia on quantitative biology. 2018;83:57-61 Epub 2019 Apr 1; Authors: Toda H, Shi M, Williams JA, Sehgal A

• Physiology Flies with Time.
  Cell. 2017 Nov 30;171(6):1232-1235; Authors: Sehgal A

• Guidelines for Genome-Scale Analysis of Biological Rhythms.
  Journal of biological rhythms. 2017 Oct;32(5):380-393 Epub 2017 Nov 3; Authors: Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB

• Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals.
  Cold Spring Harbor perspectives in biology. 2017 Aug 1;9(8); Authors: Allada R, Cirelli C, Sehgal A

• A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
  Current biology : CB. 2017 Jul 10;27(13):1915-1927.e5 Epub 2017 Jun 29; Authors: King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A

• The Drosophila circuitry of sleep-wake regulation.
  Current opinion in neurobiology. 2017 Jun;44:243-250 Epub 2017 Mar 30; Authors: Artiushin G, Sehgal A

• Circadian Rhythms and Sleep in Drosophila melanogaster.
  Genetics. 2017 Apr;205(4):1373-1397; Authors: Dubowy C, Sehgal A

• Human and rat gut microbiome composition is maintained following sleep restriction.
  Proceedings of the National Academy of Sciences of the United States of America. 2017 Feb 21;114(8):E1564-E1571 Epub 2017 Feb 8; Authors: Zhang SL, Bai L, Goel N, Bailey A, Jang CJ, Bushman FD, Meerlo P, Dinges DF, Sehgal A

• Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.
  Journal of biological rhythms. 2016 Dec;31(6):551-567 Epub 2016 Sep 22; Authors: Garbe DS, Vigderman AS, Moscato E, Dove AE, Vecsey CG, Kayser MS, Sehgal A

• Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.
  Genes & development. 2016 Dec 1;30(23):2596-2606 Epub 2016 Dec 15; Authors: Barber AF, Erion R, Holmes TC, Sehgal A

• Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila.
  Sleep. 2016 May 1;39(5):1083-95; Authors: Dubowy C, Moravcevic K, Yue Z, Wan JY, Van Dongen HP, Sehgal A

• Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue.
  eLife. 2016 Apr 14;5; Authors: Erion R, King AN, Wu G, Hogenesch JB, Sehgal A

• Control of Metabolism by Central and Peripheral Clocks in Drosophila.
  . 2016; Authors: Sassone-Corsi P, Christen Y, Sehgal A

• Circadian Rhythms, Sleep, and Disorders of Aging.
  Trends in endocrinology and metabolism: TEM. 2016 Apr;27(4):192-203 Epub 2016 Mar 3; Authors: Mattis J, Sehgal A

• Caffeine promotes wakefulness via dopamine signaling in Drosophila.
  Scientific reports. 2016 Feb 12;6:20938; Authors: Nall AH, Shakhmantsir I, Cichewicz K, Birman S, Hirsh J, Sehgal A

• The Drosophila Circadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons.
  Sleep. 2016 Feb 1;39(2):345-56; Authors: Cavanaugh DJ, Vigderman AS, Dean T, Garbe DS, Sehgal A

• Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.
  Cell metabolism. 2016 Jan 12;23(1):143-54 Epub 2015 Nov 25; Authors: Katewa SD, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, Hall D, Davis S, Nelson CS, Brem RB, Ramanathan A, Sehgal A, Giebultowicz JM, Kapahi P

• Ribosome profiling reveals an important role for translational control in circadian gene expression.
  Genome research. 2015 Dec;25(12):1836-47 Epub 2015 Sep 3; Authors: Jang C, Lahens NF, Hogenesch JB, Sehgal A

• Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.
  PLoS genetics. 2015 Nov;11(11):e1005655 Epub 2015 Nov 6; Authors: Wu Y, Gause M, Xu D, Misulovin Z, Schaaf CA, Mosarla RC, Mannino E, Shannon M, Jones E, Shi M, Chen WF, Katz OL, Sehgal A, Jongens TA, Krantz ID, Dorsett D

• Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.
  PLoS genetics. 2015 Nov;11(11):e1005611 Epub 2015 Nov 4; Authors: Bai L, Sehgal A

• Context-specific comparison of sleep acquisition systems in Drosophila.
  Biology open. 2015 Oct 30;4(11):1558-68; Authors: Garbe DS, Bollinger WL, Vigderman A, Masek P, Gertowski J, Sehgal A, Keene AC

• KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
  eLife. 2015 Aug 29;4; Authors: Lee Y, Jang AR, Francey LJ, Sehgal A, Hogenesch JB

• Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis.
  The Journal of biological chemistry. 2015 Aug 14;290(33):20407-16 Epub 2015 Jun 29; Authors: Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal A

• Sleep deprivation suppresses aggression in Drosophila.
  eLife. 2015 Jul 28;4:e07643; Authors: Kayser MS, Mainwaring B, Yue Z, Sehgal A

• Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.
  Proceedings of the National Academy of Sciences of the United States of America. 2015 Feb 24;112(8):2569-74 Epub 2015 Feb 9; Authors: Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A

• Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
  PLoS genetics. 2015 Feb;11(2):e1004974 Epub 2015 Feb 12; Authors: Jang AR, Moravcevic K, Saez L, Young MW, Sehgal A

• Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.
  Investigative ophthalmology & visual science. 2015 Feb 5;56(2):1396-405; Authors: Li SK, Banerjee J, Jang C, Sehgal A, Stone RA, Civan MM

• Heating and cooling the Drosophila melanogaster clock.
  Current opinion in insect science. 2015 Feb 1;7:71-75; Authors: Maguire SE, Sehgal A

• Methods in Enzymology. Circadian rhythms and biological clocks, part A. Preface.
  Methods in enzymology. 2015;551:xvii-xviii; Authors: Sehgal A

• Methods in Enzymology. Circadian rhythms and biological clocks, part B. Preface.
  Methods in enzymology. 2015;552:xvii-xviii; Authors: Sehgal A

• An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila.
  Nature communications. 2014 Dec 16;5:5697; Authors: Kumar S, Chen D, Jang C, Nall A, Zheng X, Sehgal A

• Casein kinase 1 promotes synchrony of the circadian clock network.
  Molecular and cellular biology. 2014 Jul;34(14):2682-94; Authors: Zheng X, Sowcik M, Chen D, Sehgal A

• Monoamines and sleep in Drosophila.
  Behavioral neuroscience. 2014 Jun;128(3):264-72; Authors: Nall A, Sehgal A

• Natural Populations of Drosophila melanogaster Reveal Features of an Uncharacterized Circadian Property: The Lower Temperature Limit of Rhythmicity.
  Journal of biological rhythms. 2014 Jun;29(3):167-180 Epub 2014 Jun 10; Authors: Maguire SE, Schmidt PS, Sehgal A

• Identification of a circadian output circuit for rest:activity rhythms in Drosophila.
  Cell. 2014 Apr 24;157(3):689-701; Authors: Cavanaugh DJ, Geratowski JD, Wooltorton JR, Spaethling JM, Hector CE, Zheng X, Johnson EC, Eberwine JH, Sehgal A

• A critical period of sleep for development of courtship circuitry and behavior in Drosophila.
  Science (New York, N.Y.). 2014 Apr 18;344(6181):269-74; Authors: Kayser MS, Yue Z, Sehgal A

• WIDE AWAKE mediates the circadian timing of sleep onset.
  Neuron. 2014 Apr 2;82(1):151-66 Epub 2014 Mar 13; Authors: Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, Wu MN

• Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.
  Proceedings of the National Academy of Sciences of the United States of America. 2014 Feb 25;111(8):3026-31 Epub 2014 Feb 10; Authors: Tulina NM, Chen WF, Chen JH, Sowcik M, Sehgal A

• Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.
  eLife. 2014;3:e01473 Epub 2014 Feb 4; Authors: Shi M, Yue Z, Kuryatov A, Lindstrom JM, Sehgal A

• New perspectives on circadian rhythms and sleep.
  Current opinion in neurobiology. 2013 Oct;23(5):721-3 Epub 2013 Jul 30; Authors: Saper CB, Sehgal A

• Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs.
  Proceedings. Biological sciences. 2013 Aug 22;280(1765):20130011 Epub 2013 Jul 3; Authors: Bartok O, Kyriacou CP, Levine J, Sehgal A, Kadener S

• Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 May 8;33(19):8534-40; Authors: Nall AH, Sehgal A

• Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.
  PLoS genetics. 2013;9(9):e1003605 Epub 2013 Sep 5; Authors: Joiner WJ, Friedman EB, Hung HT, Koh K, Sowcik M, Sehgal A, Kelz MB

• Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.
  PLoS genetics. 2013;9(9):e1003749 Epub 2013 Sep 26; Authors: Garbe DS, Fang Y, Zheng X, Sowcik M, Anjum R, Gygi SP, Sehgal A

• Interaction between sleep and metabolism in Drosophila with altered octopamine signaling.
  The Journal of biological chemistry. 2012 Sep 21;287(39):32406-14 Epub 2012 Jul 24; Authors: Erion R, DiAngelo JR, Crocker A, Sehgal A

• Speed control: cogs and gears that drive the circadian clock.
  Trends in neurosciences. 2012 Sep;35(9):574-85 Epub 2012 Jun 28; Authors: Zheng X, Sehgal A

• Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations.
  Aging cell. 2012 Jun;11(3):428-38 Epub 2012 Feb 24; Authors: Luo W, Chen WF, Yue Z, Chen D, Sowcik M, Sehgal A, Zheng X

• Dopamine acts through Cryptochrome to promote acute arousal in Drosophila.
  Genes & development. 2012 Jun 1;26(11):1224-34 Epub 2012 May 11; Authors: Kumar S, Chen D, Sehgal A

• Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.
  Cell. 2012 Feb 17;148(4):765-79 Epub 2012 Feb 2; Authors: Luo W, Sehgal A

• Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Aug 3;31(31):11387-95; Authors: Dean T, Xu R, Joiner W, Sehgal A, Hoshi T

• Genetics of sleep and sleep disorders.
  Cell. 2011 Jul 22;146(2):194-207; Authors: Sehgal A, Mignot E

• Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Jul 6;31(27):9982-90; Authors: Hara T, Koh K, Combs DJ, Sehgal A

• The circadian clock interacts with metabolic physiology to influence reproductive fitness.
  Cell metabolism. 2011 Jun 8;13(6):639-54; Authors: Xu K, DiAngelo JR, Hughes ME, Hogenesch JB, Sehgal A

• The central clock neurons regulate lipid storage in Drosophila.
  PloS one. 2011;6(5):e19921 Epub 2011 May 18; Authors: DiAngelo JR, Erion R, Crocker A, Sehgal A

• Effect of taurine and caffeine on sleep-wake activity in Drosophila melanogaster.
  Nature and science of sleep. 2010;2:221-31 Epub 2010 Sep 24; Authors: Lin FJ, Pierce MM, Sehgal A, Wu T, Skipper DC, Chabba R

• A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia.
  PloS one. 2010 Jul 30;5(7):e11903; Authors: Friedman EB, Sun Y, Moore JT, Hung HT, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB

• AKT and TOR signaling set the pace of the circadian pacemaker.
  Current biology : CB. 2010 Jul 13;20(13):1203-8 Epub 2010 Jun 17; Authors: Zheng X, Sehgal A

• Genetic analysis of sleep.
  Genes & development. 2010 Jun 15;24(12):1220-35; Authors: Crocker A, Sehgal A

• Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior.
  Neuron. 2010 Mar 11;65(5):670-81; Authors: Crocker A, Shahidullah M, Levitan IB, Sehgal A

• SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.
  Nature neuroscience. 2010 Jan;13(1):69-75 Epub 2009 Dec 13; Authors: Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K

• An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Sep 2;29(35):10920-7; Authors: Zheng X, Koh K, Sowcik M, Smith CJ, Chen D, Wu MN, Sehgal A

• The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Sep 2;29(35):11029-37; Authors: Wu MN, Ho K, Crocker A, Yue Z, Koh K, Sehgal A

• Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster.
  PloS one. 2009 Jul 10;4(7):e6211; Authors: Harbison ST, Sehgal A

• Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila.
  Cell metabolism. 2008 Oct;8(4):289-300; Authors: Xu K, Zheng X, Sehgal A

• Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Sep 17;28(38):9377-85; Authors: Crocker A, Sehgal A

• A Drosophila model for Angelman syndrome.
  Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 26;105(34):12399-404 Epub 2008 Aug 13; Authors: Wu Y, Bolduc FV, Bell K, Tully T, Fang Y, Sehgal A, Fischer JA

• Identification of SLEEPLESS, a sleep-promoting factor.
  Science (New York, N.Y.). 2008 Jul 18;321(5887):372-6; Authors: Koh K, Joiner WJ, Wu MN, Yue Z, Smith CJ, Sehgal A

• Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.
  Genes & development. 2008 Jun 1;22(11):1522-33; Authors: Sathyanarayanan S, Zheng X, Kumar S, Chen CH, Chen D, Hay B, Sehgal A

• Quantitative genetic analysis of sleep in Drosophila melanogaster.
  Genetics. 2008 Apr;178(4):2341-60; Authors: Harbison ST, Sehgal A

• A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila.
  Sleep. 2008 Apr;31(4):465-72; Authors: Wu MN, Koh K, Yue Z, Joiner WJ, Sehgal A

• Probing the relative importance of molecular oscillations in the circadian clock.
  Genetics. 2008 Mar;178(3):1147-55; Authors: Zheng X, Sehgal A

• The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice.
  Journal of biological rhythms. 2008 Feb;23(1):26-36; Authors: Alvarez JD, Hansen A, Ord T, Bebas P, Chappell PE, Giebultowicz JM, Williams C, Moss S, Sehgal A

• Ac-ing the clock.
  Neuron. 2008 Jan 10;57(1):8-10; Authors: Sehgal A

• FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress.
  Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 2;104(40):15899-904 Epub 2007 Sep 25; Authors: Zheng X, Yang Z, Yue Z, Alvarez JD, Sehgal A

• Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1).
  Genes & development. 2007 Jun 15;21(12):1506-18; Authors: Fang Y, Sathyanarayanan S, Sehgal A

• Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish.
  Sleep. 2007 Apr;30(4):389-400; Authors: Williams JA, Sathyanarayanan S, Hendricks JC, Sehgal A

• A Drosophila model for age-associated changes in sleep:wake cycles.
  Proceedings of the National Academy of Sciences of the United States of America. 2006 Sep 12;103(37):13843-7 Epub 2006 Aug 28; Authors: Koh K, Evans JM, Hendricks JC, Sehgal A

• JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.
  Science (New York, N.Y.). 2006 Jun 23;312(5781):1809-12; Authors: Koh K, Zheng X, Sehgal A

• Sleep in Drosophila is regulated by adult mushroom bodies.
  Nature. 2006 Jun 8;441(7094):757-60; Authors: Joiner WJ, Crocker A, White BH, Sehgal A

• A sleep-promoting role for the Drosophila serotonin receptor 1A.
  Current biology : CB. 2006 Jun 6;16(11):1051-62; Authors: Yuan Q, Joiner WJ, Sehgal A

• Serotonin modulates circadian entrainment in Drosophila.
  Neuron. 2005 Jul 7;47(1):115-27; Authors: Yuan Q, Lin F, Zheng X, Sehgal A

• The thymus is similar to the testis in its pattern of circadian clock gene expression.
  Journal of biological rhythms. 2005 Apr;20(2):111-21; Authors: Alvarez JD, Sehgal A

• Drosophila melanogaster: an insect model for fundamental studies of sleep.
  Methods in enzymology. 2005;393:772-93; Authors: Ho KS, Sehgal A

• Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep.
  Sleep. 2004 Mar 15;27(2):334-42; Authors: Hendricks JC, Sehgal A

• Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
  Cell. 2004 Feb 20;116(4):603-15; Authors: Sathyanarayanan S, Zheng X, Xiao R, Sehgal A

• Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila.
  BMC neuroscience. 2004 Jan 27;5:3; Authors: Jaramillo AM, Zheng X, Zhou Y, Amado DA, Sheldon A, Sehgal A, Levitan IB

• Novel insights into the regulation of the timeless protein.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Aug 27;23(21):7810-9; Authors: Ashmore LJ, Sathyanarayanan S, Silvestre DW, Emerson MM, Schotland P, Sehgal A

• An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Jul 9;23(14):6141-51; Authors: Nagano M, Adachi A, Nakahama K, Nakamura T, Tamada M, Meyer-Bernstein E, Sehgal A, Shigeyoshi Y

• Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis.
  Biology of reproduction. 2003 Jul;69(1):81-91 Epub 2003 Feb 19; Authors: Alvarez JD, Chen D, Storer E, Sehgal A

• A fly's eye view of circadian entrainment.
  Journal of biological rhythms. 2003 Jun;18(3):206-16; Authors: Ashmore LJ, Sehgal A

• Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster.
  Current biology : CB. 2003 Mar 18;13(6):526-33; Authors: Myers EM, Yu J, Sehgal A

• Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster.
  Journal of biological rhythms. 2003 Feb;18(1):12-25; Authors: Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, Sehgal A

• Circadian rhythms: finer clock control.
  Nature. 2002 Oct 24;419(6909):798-9; Authors: Alvarez JD, Sehgal A

• REV-ving up the clock.
  Developmental cell. 2002 Aug;3(2):150-2; Authors: Alvarez JD, Sehgal A

• Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest.
  Neuron. 2002 Jun 13;34(6):973-84; Authors: Dockendorff TC, Su HS, McBride SM, Yang Z, Choi CH, Siwicki KK, Sehgal A, Jongens TA

• Signaling components that drive circadian rhythms.
  Current opinion in neurobiology. 2002 Jun;12(3):331-8; Authors: Wang GK, Sehgal A

• Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2.
  Genes to cells : devoted to molecular & cellular mechanisms. 2002 Feb;7(2):163-71; Authors: Shigeyoshi Y, Meyer-Bernstein E, Yagita K, Fu W, Chen Y, Takumi T, Schotland P, Sehgal A, Okamura H