About Us
Our lab aims to develop molecular and cellular solutions to address important challenges in the biomedical sciences and clinical medicine, especially in the areas of imaging and diagnostics. We create small molecules, engineered proteins and cell-based tools that can "light up" and control in vivo biology using principles of chemical and synthetic biology. When possible, our technologies are translated to the clinic using nuclear medicine and molecular imaging techniques. For example, our group recently pioneered the development, preclinical testing, and human application of a new class of positron emission tomography (PET) radiotracers based on the small molecule antibiotic trimethoprim. These molecules have diverse applications in our broad fields of investigation including cancer biology, immunology, and infectious disease. If you have any questions about who we are and what we do, don't hesitate to reach out to us!
Announcements
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Congrats to Gabrielle and Swarbhanu!
Congrats to Gabrielle and Swarbhanu on their recently published papers! Gabrielle's work on imaging protein expression from mRNA-LNP in vivo was published in Nature Communications and Swarbhanu's work on developing a bio-orthogonal chemistry approach for improved imaging with radiolabeled antibodies was published in EJNMMI Research. Check our their work in the "Publications" section of the website! These projects have been a long journey for both Gabrielle and Swarbhanu, so we're very proud of these accomplishments!
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Welcome to Chelsea, Aishwarya, and Daniel!
The lab is abound with new faces and fresh talent! Chelsea is joining the lab as a BBCB PhD student having previously worked in the Baker Lab at the University of Washington and at Dana Farber. We also have two new Penn undergraduates in the lab - Aishwarya, a sophomore in the Life Sciences & Management Program, and Daniel, a freshman interested in radiology. We look forward to all they will accomplish in the lab. Welcome!
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Congratulations (and farewell) to Jean, Tommy, and Hwan!
We bid farewell to Jean, Tommy, and Hwan as they graduate to advanced training opportunities - Jean as a post-doctoral scholar at Memorial Sloan-Kettering Cancer Center, Tommy as an MD-PhD student at Case Western Reserve University, and Hwan as a nuclear radiology fellow at Massachusetts General Hospital. We are so excited to see all that they will accomplish in their new roles!