Pilot Study of an integrated sleep platform for individuals with PTSD and Insomnia
Cohen Veterans Biosciences
This study seeks to determine the extent to which consumer wearables can accurately assess sleep in individuals with PTSD and insomnia compared to polysomnography
PI: Philip Gehrman, PhD
Status: active. 11/1/2019-10/31/2020.
Characterizing sleep with trauma nightmares using ambulatory sleep measurement
Career Development Award (IK2 CX001874); Department of Veterans Affairs; Clinical Science R&D
PI: Katherine Miller, PhD
In spite of an urgent need to reduce the burden of trauma-related nightmares, the underlying physiological changes associated with them are poorly understood, and there are no clear evidence-based recommendations for their treatment. Limitations of current assessment procedures represent a barrier to improved care. In-laboratory sleep studies rarely capture nightmares, limiting the knowledge about them and their response to treatment. This study addresses these limitations by using extended, in-home sleep monitoring to capture sleep data associated with nightmare reports in Veterans, and assessing how these features are altered throughout a cognitive-behavioral nightmare treatment. Results from this study will increase understanding of trauma-related nightmares, and advance strategies for personalizing symptom management for Veterans.
Status: active. 07/01/2019-06/30/2024.
Investigating the Role of Slow-Wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder
Career Development Award (K23 MH118580); National Institutes of Health, National Institute of Mental Health
PI: Jennifer Goldschmied, PhD
Standard treatments for major depressive disorder typically take at least 2-3 weeks to take effect. Discovery of novel therapies requires a better understanding of the underlying mechanisms responsible for the development and maintenance of disturbed mood. The proposed study will examine the role of sleep slow-wave activity in modifying markers associated with synaptic plasticity, which has been shown to be impaired in depression, thereby improving our understanding of the disorder and identifying a potential target for intervention.
Status: active. 07/15/2019-06/30/2023.
Elucidation of Genetic Effects of Sleep and Circadian Traits
1R01HL143790-01 ; National Institutes of Health, National Heart, Lung, Blood Institute
This project is using a combination of GWAS, cellular and model systems to identify genes and genetic variants associated with insomnia and chronotype.
PI: Philip Gehrman, PhD
Status: active. 9/1/2018-6/30/2022.
Chronic Insomnia and CSF Markers of Dementia
MISP #57350; Merck
This study involves collection of CSF samples from patients with chronic insomnia and good sleepers to determine if insomnia is associated with elevations in proteins related to Alzheimer’s disease.
PI: Philip Gehrman, PhD
Status: active. 04/13/18-04/12/20.
The Role of Effort Discounting in the Link Between Insomnia and Depression.
Career Development Award (IK2 CX001501); Department of Veterans Affairs; Clinical Science R&D
PI: Elaine Boland, PhD
This 5-year training grant aims to support my career development through a clinical research study exploring reward processing dysfunction, with a particular emphasis on reward-related effort discounting, as a mediator of the depression-insomnia comorbidity. In so doing, a goal of this project is to inform the development of treatment guidelines for Veterans with comorbid depression and insomnia.
Status: active. 07/01/2017-06/30/2022.
Telemedicine vs. in-person delivery of cognitive behavioral treatment of insomnia
167-SR-17; American Sleep Medicine Foundation
This study is comparing the efficacy of cognitive behavioral treatment for insomnia delivered in-person to delivery by video telehealth.
PI: Philip Gehrman, PhD
Status: active. 5/1/2017-4/23/2020.
Neural mechanisms underlying the antidepressant effects of sleep deprivation
1R01MH107571-04; National Institutes of Health, National Institute of Mental Health
The goal of this project is to identify the neural circuits involved in the rapid antidepressant effects of a night of total sleep deprivation in patients with major depressive disorder.
PI: Philip Gehrman, PhD
Status: active.  4/1/2016-1/31/2020.