Resources for Trainees

On every other Thursday, the trainees from the "Immune System Development and Regulation" and the trainees from the "Immunobiology of Normal and Neoplastic Lymphocytes" get together for lunch. For each of these meetings, there is a designated trainee speaker who presents their research and gets feedback from their peers and the program directors. Below is a list of our 2024-2025 meetings:

November 2024

Trainee: Austin Good: “Mechanisms of PARPi resistance in hrdPDAC”

Alumni: Josephine Giles: “My life as an academic staff scientist”.

December 2024

Trainee: Sean Callahan: “ACSS2 epigenetically regulates M2 macrophage polarization”.

Faculty: Ben Stanger: “How to communicate your science effectively: Pro-tips from an amateur”

January 2025

Trainee: Alberto Guerra: Targeting the anaplastic lymphoma kinase (ALK) with novel immunotherapeutic platforms in pediatric and adult cancers”

February 2025

Trainee: Donn Van Deren: “Investigating the Impact of Peripheral Solid Tumors on Border-Associated Macrophages in the Murine Brain”

March 2025

Trainee: Molly Bunkofske: CD8+ T cell recognition of cyst-derived antigen during chronic Toxoplasma gondii infection

April 2025

Trainee: Charles Drummer: “Mapping the Microexon Landscape in Pediatric Cancers: A Target Discovery Pipeline”

May 2025

Trainee: Shannon McGettigan: Investigating the Impact of P2RX4 Signaling and Survival in Normal Plasma Cells and Multiple Myeloma"

Alumni: Khoa Train: “Spatial Regulation of Chromatin Associated Proteins During Cellular

June 2025

Trainee: Grant Kinsler: "Pre-existing non-genetic cellular states determine susceptibility to oncogenic transformation"

Biyik Sit, Rumeysa et al. 2025. Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring. Nat Genet. PMID: 40229600.

Blanchard, Tatiana et al. 2025. LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma. Sci Rep, 15, 13007. PMID: 40234527.

Hamilton, Amber et al. 2024. A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma. Cancer Cell, 42, 1970-1982.e7. PMID: 39454577.

Kahn, Benjamin et al. 2025. Intrinsic properties of the lymph node render it immunologically susceptible to metastasis. Cancer Discov. PMID: 40265527.

Matthew, Divij et al.  2024. Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients. Science, 384, eadf1329. PMID: 38900877.

Stone, Meredith et al. 2024. Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins. Nat Immunol, 25, 755-763. PMID: 38641718.

Tran, Khoa et al. 2024. SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging. bioRxiv. PMID: 38370824.

Kemp, Samantha et al. 2023. Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer. Cancer Discov, 13, 298-311. PMID: 36472553.

Giles, Josephine et al.  2022. Shared and distinct biological circuits in effector, memory and exhausted CD8(+) T cells revealed by temporal single-cell transcriptomics and epigenetics. Nat Immunol, 23, 1600-1613. PMID: 36271148.

Kim, Gloria et al. 2022. Quantitative immunopeptidomics reveals a tumor stroma-specific target for T cell therapy. Sci Transl Med, 14, eabo6135. PMID: 36044599.

Lund, Peder et al. 2022. Stable isotope tracing in vivo reveals a metabolic bridge linking the microbiota to host histone acetylation. Cell Rep, 41, 111809. PMID: 36516747.

Perry, Joseph et al. 2022. PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nat Immunol, 23, 743-756. PMID: 35437326.

Guadette, Brian et al. 2021. Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation. J Clin Invest, 131. PMID: 34473651.

Lanauze, Claudia et al. 2021. Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/beta- Catenin Signaling through Enhanced Smad4-LEF1 Binding. Mol Cancer Res, 19, 823-833. PMID: 33608451.

Schwartz, Gregory et al. 2021. TooManyPeaks identifies drug-resistant-specific regulatory elements from single-cell leukemic epigenomes. Cell Rep, 36, 109575. PMID: 34433064.

Chirino, Leilani et al. 2020. TAM receptors attenuate murine NK-cell responses via E3 ubiquitin ligase Cbl-b. Eur J Immunol, 50, 48-55. PMID: 31531847.

Goldsmith, Jason et al. 2020. TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. Nat Commun, 11, 2591. PMID: 32444641.

Payne, Kyle et al. 2020. BTN3A1 governs antitumor responses by coordinating alphabeta and gammadelta T cells. Science, 369, 942-949. PMID: 32820120.

Rome, Kelly et al. 2020. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. J Exp Med, 217. PMID: 32150623.

Roy, Nathan et al. 2020. LFA-1 signals to promote actin polymerization and upstream migration in T cells. J Cell Sci, 133. PMID: 32907931.

Walton, Zandra et al. 2018. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell, 174, 72-87.e32. PMID: 29861175.

Hu, Biliang et al.  2017. Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18. Cell Rep, 20, 3025-3033. PMID: 28954221.

Layman, Awo Akosua Kesewa et al.  2017. Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease. Nat Commun, 8, 15677. PMID: 28580955.

Chao, Timothy Hue-Fung, et al. 2016. CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma. Cancer Immunol Res, 4, 968-982. PMID: 27737879.

Smith, Janessa et al. 2016. Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy. Mol Ther, 24, 1987-1999. PMID: 27439899.