Renyu Liu, M.D., M.S., Ph.D.
Renyu Liu, M.D., M.S., Ph.D.
Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesiology and Critical Care
336 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
336 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 2156623750
Fax: 2153495078
Lab: 2156623750
Fax: 2153495078
Lab: 2156623750
Email:
liur@uphs.upenn.edu
liur@uphs.upenn.edu
Publications
Education:
M.D. (Medicine)
Xuzhou Medical College, China, 1990.
MS
Jiaotong University School of Medicine, China, 1993.
Ph.D.
Tottori University School of Medicine, Japan, 2000.
Permanent linkM.D. (Medicine)
Xuzhou Medical College, China, 1990.
MS
Jiaotong University School of Medicine, China, 1993.
Ph.D.
Tottori University School of Medicine, Japan, 2000.
Description of Research Expertise
My major research interests are as follows:1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
2) Pharmacological effects of opioid receptor agonists.
3) Anesthetic interaction with proteins
4) Preoperative evaluation and outcome
Description of Clinical Expertise
Anesthesia for general surgery patientsPerioperative Medicine
outside OR anesthesia services
optimal opioid usage in perioperative period
Description of Other Expertise
Editor in Chief, Journal of Anesthsia and Clinical ResearchPartnership with Chinese anesthesiolgists
Selected Publications
Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R.: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model. Brain Research November 2012.Perez-Aguilar JM, Saven JG, Liu R: Human µ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine µ Opioid Receptor. J Anesth Clin Res 3(218): doi:10.4172/2155-6148.1000218, July 2012.
Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin Couples Iron and Fatty Acid Metabolism. FASEB Journal 26(6): 2394-400, June 2012.
Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallographica Section D 68(5): 497-504, May 2012.
Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking. Anesthesia & Analgesia 114(5): 947-55, March 2012.
Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines. J Anesthe Clinic Res 3(1): 192. doi: 10.4172/2155- 6148.1000192, Feb 2012.
Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein Binding Site: A high resolution structural analysis. PLoS ONE 7(7(2):e32070): in press, 2012 Notes: Epub 2012 Feb 16.
Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel. Anesthesiology Page: A713, 2010.
Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets. Anesthesia & Analgesia Nov 10 [Epub ahead of print] 2011.
Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A Administration after Global Cerebral Hypoxia/Ischemia Preserves Cerebrovascular Autoregulation via Kappa Opioid Receptor in Piglets. PlosOne 7(7): e41724. Epub 2012 Jul 24, 2012.
Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin. Anesthesia & Analgesia 114(1): 122-8, Oct 24 [Epub ahead of print] 2012.
Su D, Riley J, Kiessling WJ, Armstead WM, Liu R : Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology 114(2): 374-9, Feb 2011.
Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume. Anesth & Analg Dec 7 2012.