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Renyu Liu, M.D., M.S., Ph.D.
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Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
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Attending Anesthesiologist, Hospital of the University of Pennsylvania, Philadelphia, PA
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Faculty, The Institute for Translational Medicine and Therapeutics, University of Pennsylvania
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Center of Penn Global Heath Scholar, University of Pennsylvania
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Director for the Center of Product Innovation , Department of Anesthesiology and Critical Care at the Perelman School of Medicine
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Department: Anesthesiology and Critical Care
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Graduate Group Affiliations
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- Pharmacology e
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Contact information
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Department of Anesthesiology and Critical Care
20 336 John Morgan Building
35 3620 Hamilton Walk
Philadelphia, PA 19104
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20 336 John Morgan Building
35 3620 Hamilton Walk
Philadelphia, PA 19104
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Office: 2157461485
30 Fax: 2153495078
30 Lab: 2158983891
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30 Fax: 2153495078
30 Lab: 2158983891
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Publications
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Links
108 Search PubMed for articles
8c A website to promote stroke awareness in China designed and edited by me
77 ITMAT faculty
77 The Center for Anesthesia Research
7b departmental web info
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108 Search PubMed for articles
8c A website to promote stroke awareness in China designed and edited by me
77 ITMAT faculty
77 The Center for Anesthesia Research
7b departmental web info
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Education:
21 9 M.D. 15 (Medicine) c
36 Xuzhou Medical College, China, 1990.
21 9 M.S. c
46 Jiaotong University School of Medicine, China, 1993.
21 a Ph.D. c
45 Tottori University School of Medicine, Japan, 2000.
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Permanent link21 9 M.D. 15 (Medicine) c
36 Xuzhou Medical College, China, 1990.
21 9 M.S. c
46 Jiaotong University School of Medicine, China, 1993.
21 a Ph.D. c
45 Tottori University School of Medicine, Japan, 2000.
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cc 1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
40 2) Pharmacological effects of opioid receptor agonists.
2f 3) Anesthetic interaction with proteins
2d 4) Preoperative evaluation and outcome
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1e Perioperative Medicine
26 outside OR anesthesia services
33 optimal opioid usage in perioperative period
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Description of Research Expertise
3c My major research interests are as follows:cc 1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
40 2) Pharmacological effects of opioid receptor agonists.
2f 3) Anesthetic interaction with proteins
2d 4) Preoperative evaluation and outcome
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Description of Clinical Expertise
38 Anesthesia for general surgery patients1e Perioperative Medicine
26 outside OR anesthesia services
33 optimal opioid usage in perioperative period
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Description of Other Expertise
4e Editor in Chief, Translational Perioperative and Pain Medicinee 29
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129 Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3(218): doi:10.4172/2155-6148.1000218, 2012.
dc Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism. FASEB J 26(6): 2394-23400, 2012.
130 Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallogr D Biol Crystallogr 68(5): 497-504, 2012.
f6 Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking. Anesth Analg 114(5): 947-955, 2012.
100 Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines. J Anesth Clin Res 3(1): 192. DOI: 10.4172/2155- 6148.1000192, 2012.
ba Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high 49 resolution structural analysis. PLoS One 7(2): e32070, 2012 Notes: 14
5b Su D, Riley J, Kiessling WJ, Armstead WM, Liu R e2 : Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology 114(2): 374-379, 2011.
cc Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin. Anesth Analg 114(1): 122-128, 2012.
11c Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets. Anesth Anal 114(1): 200-204, 2011.
e6 Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel. Anesthesiology Page: A713, 2010.
113 Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume. Anesth Analg 116(1): 112-117, 2013.
121 Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. PLoS One 7(7): e41724, 2012.
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Selected Publications
11d Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model. Brain Res 1490: 95-100, 2013.129 Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3(218): doi:10.4172/2155-6148.1000218, 2012.
dc Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism. FASEB J 26(6): 2394-23400, 2012.
130 Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallogr D Biol Crystallogr 68(5): 497-504, 2012.
f6 Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking. Anesth Analg 114(5): 947-955, 2012.
100 Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines. J Anesth Clin Res 3(1): 192. DOI: 10.4172/2155- 6148.1000192, 2012.
ba Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high 49 resolution structural analysis. PLoS One 7(2): e32070, 2012 Notes: 14
5b Su D, Riley J, Kiessling WJ, Armstead WM, Liu R e2 : Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology 114(2): 374-379, 2011.
cc Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin. Anesth Analg 114(1): 122-128, 2012.
11c Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets. Anesth Anal 114(1): 200-204, 2011.
e6 Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel. Anesthesiology Page: A713, 2010.
113 Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume. Anesth Analg 116(1): 112-117, 2013.
121 Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. PLoS One 7(7): e41724, 2012.
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