Neurosurgery

Faculty

faculty photo

Neil R. Malhotra, M.D.

Assistant Professor of Neurosurgery at the Pennsylvania Hospital
Attending Neurosurgeon, Hospital of the University of Pennsylvania. Philadelphia, PA, USA
Attending Neurosurgeon, The Pennsylvania Hospital. Philadelphia, PA, USA
Director, Neurosurgery Quality Improvement Initiative, Department of Neurological Surgery, University of Pennsylvania. Philadelphia, PA, USA
Co-Director, Translational Research Laboratory, Co-Director, Translational Spine Research Laboratory of the Perelman School of Medicine, University of Pennsylvania. Philadelphia, PA, USA
Attending Neurosurgeon, Penn Presbyterian Medical Center. Philadelphia, PA, USA
Vice Chairman for Operations, Department of Neurological Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Department: Neurosurgery

Contact information
Vice Chairman for Operations

Director, Neurosurgery Quality Improvement Initiative

Co-Director, Translational Research Lab

Department of Neurosurgery
3rd Floor Silverstein Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5454
Fax: 215-349-5534
Education:
BA (High Distinction Scholar)
University of Virginia, 1997.
MD (Doctor of Medicine)
University of Virginia, 2002.
Post-Graduate Training
Intern in General Surgery, University of Pennsylvania, Department of Surgery, 2002-2003.
Resident in Neurosurgery, University of Pennsylvania, Department of Neurosurgery, 2003-2008.
Fellow in Neurosurgery, Senior Specialist Registrar, Southwest Neurosurgical Centre, Derriford Hospital, UK Fellowship Coordinator: Anne J. Moore MD, MBBS, BSc, FRCS , 2007-2007.
Chief Resident, University of Pennsylvania, Department of Neurosurgery, 2008-2009.
Certifications
American Board of Neurosurgery, Board Eligible, 2009.
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Description of Research Expertise

As co-director of the translational spinal research laboratory, Dr. Malhotra's primary research interests focus on restorative approaches to treat disc degeneration. His novel approaches have led to multiple awards and research grants. Through his work, Dr. Malhotra hopes to reduce the need for invasive surgery and offer better treatments for disc degeneration. His interests focus on tissue engineering in order to develop treatments to restore native tissue mechanics of the spine while also delivering therapeutic agents and supporting tissue regeneration.

Description of Clinical Expertise

Dr. Malhotra is the Vice Chairman for Operations of the Department of Neurological Surgery. He oversees strategic initiatives to enhance the quality of patient care. Dr. Malhotra has published more than 50 articles and book chapters related to his clinical and research work. Dr. Malhotra's work, along with that of his partners, has led to the University of Pennsylvania being the top rated neurosurgical department in the region for every year that the rankings have been completed. Further, the department is ranked amongst the top 10 in the United States.

From a clinical standpoint, Dr. Malhotra provides expertise in the care of brain and spine neurological disorders. He takes particular interest in the development of advanced approaches to brain and spinal tumor resection and spinal column reconstruction in addition to the treatment of cervical and lumbar disc herniation. His clinical goals focus on optimizing quality of life as well as life expectancy for disorders of the nervous system. When surgery is not necessary, Dr. Malhotra leads the interdisciplinary physician group to ensure the appropriate medical professionals provide optimal care to his patients.

As director and creator of the Neurosurgery Quality Improvement Initiative Dr. Malhotra has developed a software system within the electronic medical record system to enhance disease management and predict response to therapy. His system, the EpiLog project, has completed beta testing. Not only is it currently in use at the University of Pennsylvania but it is also being considered for adoption at a wide range of national institutions.

In 2011, Dr. Malhotra developed an outreach program in order to enhance and facilitate patient care. To support this program Dr. Malhotra sees patients in King of Prussia and Chestnut Hill, in addition to his primary site at the University of Pennsylvania.

Selected Publications

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate infusion for intractable intracranial hypertension and its effect on brain oxygenation. Neurosurgery 63(5): 880-6, Nov 2008.

Stein SC, Malhotra NR, Burnett MG: Cost-Effectiveness Analysis. J Neurosurg Spine Apr 2014.

Malhotra NR: Improving Surgical Care of the Spinal Disorders: The Osteoporotic Spine. J Osteopor Phys Act 2013 Notes: (Invited Editorial).

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-outcome relationship in neurotrauma care. J Neurosurg December 2012 Notes: PODCAST.

Malhotra NR, Whitmore R, Smith LJ, Welch WC, Schuster JM, Marcotte P, Dante S, Arlet V, Brem S, Grady MS: Future Directions in Spine: An Opportunity to Accelerate Quality Improvement. J Spine Neurosurg 2012.

Lang SS, Chen HI, Koch MJ, Kurash L, McGill-Armento KR, Palella JM, Stein SC, Malhotra NR: Development of an outpatient protocol for lumbar discectomy: Our institutional experience. World Neurosurg Jun 2014.

Chiaro JA, O'Donnell P, Shore EM, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. J Bone Miner Res Jun 2014.

Showalter BL, Malhotra NR, Vresilovic EJ, Elliott DM: Nucleotomy reduces the effects of cyclic compressive loading with unloaded recovery on human intervertebral discs. J Biomech Aug 2014.

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Elliott DM, Mauck RL, Chen, Malhotra NR: In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus. Tissue Eng Part A July 2014.

Malhotra NR, Kosty J, Sanborn M, Bekisz JM, Mooncai TW, Neustein TM, Ou J, Zhu A, Bernstein A, Stein SC: Optimal Approach to Circumferential Decompression and Reconstruction for Thoracic Spine Metastatic Disease. Ann Surg Oncol April 2014.

Stein SC, Malhotra NR, Burnett MG: Cost-effectiveness analysis. J Neurosurg Spine April 2014.

Nestorovski D, Milby AH, Pallavi G, Smith LJ, Smith HE, Malhotra NR: Combined treatment approach for rare occipito-cervical spinal lesions: Leiomyosarcoma. J Spine Neurosurg July 2013.

Bohman LE, Stephen JH, Ramakrishna R, Schuster JM, Malhotra NR : Postoperative Ambulatory Status Predicts Survival in Patients with Glioblastoma Multiforme. J Spine Neurosurg May 2013.

Ali Z, Barkley A, Malhotra NR : Acute Spinal Subdural Hematoma Subsequent To Posterior Lumbar Fusion. J Osteopor Phys Mar 2013.

Lang SS, Schuster JM, Smith LJ, Dwyer-Joyce L, Welch W, Marcotte P, Winkelstein B, Malhotra NR : Hemorrhage into Synovial Cysts as a Cause of Acute Radicular Symptoms. J Spine Neurosurg. Dec 2012.

Chen H Isaac, Lang Shih-Shan, Coyne Thomas M, Malhotra Neil R, Schuster James M: Intramedullary Spinal Sarcoidosis Masquerading as Cervical Stenosis. World neurosurgery Oct 2012.

Clement R Carter, Carr Brendan G, Kallan Michael J, Wolff Catherine, Reilly Patrick M, Malhotra Neil R: Volume-outcome relationship in neurotrauma care. Journal of neurosurgery 118(3): 687-93, Mar 2013.

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady M Sean: Implementation of a Departmental Picture Archiving and Communication System (PACS): A Productivity and Cost Analysis. Neurosurgery May 2013.

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady Sean M: Implementation of a departmental picture archiving and communication system: a productivity and cost analysis. Neurosurgery 73(3): 528-33, Sep 2013.

Syre P, Petrov D, Malhotra NR: Management of upper cervical spine injuries (Invited Review). Journal of neurosurgical sciences 57(3): 219-40, Sep 2013.

Syre Peter, Rodriguez-Cruz Leonardo, Desai Rajiv, Greene Karl A, Hurst Robert, Schuster James, Malhotra Neil R, Marcotte Paul: Civilian gunshot wounds to the atlantoaxial spine: a report of 10 cases treated using a multidisciplinary approach. Journal of neurosurgery. Spine Sep 2013.

Ghogawala Zoher, Shaffrey Christopher I, Asher Anthony L, Heary Robert F, Logvinenko Tanya, Malhotra Neil R, Dante Stephen J, Hurlbert R John, Douglas Andrea F, Magge Subu N, Mummaneni Praveen V, Cheng Joseph S, Smith Justin S, Kaiser Michael G, Abbed Khalid M, Sciubba Daniel M, Resnick Daniel K: The efficacy of lumbar discectomy and single-level fusion for spondylolisthesis: results from the NeuroPoint-SD registry. Journal of neurosurgery, Spine 19(5): 555-63, Nov 2013.

Malhotra Neil R, Han Woojin M, Beckstein Jesse, Cloyd Jordan, Chen Weiliam, Elliott Dawn M: An injectable nucleus pulposus implant restores compressive range of motion in the ovine disc. Spine 37(18): E1099-105, Aug 2012.

Sanborn Matthew R, Thawani Jayesh P, Whitmore Robert G, Shmulevich Michael, Hardy Benjamin, Benedetto Conrad, Malhotra Neil R, Marcotte Paul, Welch William C, Dante Stephen, Stein Sherman C: Cost-effectiveness of confirmatory techniques for the placement of lumbar pedicle screws. Neurosurgical focus 33(1): E12, Jul 2012.

O'Connell Grace D, Malhotra Neil R, Vresilovic Edward J, Elliott Dawn M: The effect of nucleotomy and the dependence of degeneration of human intervertebral disc strain in axial compression. Spine October 2011.

Boockvar JA, Stiefel M, Malhotra NR, Dolinskas C, Dwyer-Joyce C, LeRoux PD: Dural Cavernous Angioma of the Posterior Sagittal Sinus Surg Neurol 63(2): 178-181, Feb. 2005.

Gaston B, Ratjen F, Vaughan JW, Malhotra NR, Canady RG, Snyder AH, Hunt JF, Gaertig S, Goldberg JB: Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapy. Am J Respir Crit Care Med. 165(3): 387-90, Feb. 2002.

Hunt JF, Erwin E, Palmer L, Vaughan J, Malhotra N, Platts-Mills TA, Gaston B: Expression and activity of pH-regulatory glutaminase in the human airway epithelium. Am J Respir Crit Care Med. 165(1): 101-7, Jan. 2002.

Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TA, Gaston B: Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med. 161(3 part 1): 694-9, Mar 2000.

Malhotra NR: The Best Operation for Chronic Subdural Hematoma: A Decision Analysis. Best Scientific Poster Award: Pennsylvania Neurosurgical Society Meeting, Hershey, PA. July 2008 Notes: Abstract presentation.

Malhotra NR, Spiotta A, Jackson E, Maloney-Wilensky E, LeRoux P: Effects of DVT prophylaxis of Cerebral Oxygenation (Oral Presentation). Pennsylvania Neurosurgical Society Aug 2004.

Stiefel M, Spiotta A, Gracias V, Heuer GG, Danish S, Magge S, Malhotra NR, Jackson E, Zaghloul K, Maloney-Wilensky E, Grady MS, Leroux PD: Brain tissue oxygen-guided management reduces mortality in traumatic brain injury. Neurocritical Care Society Feb 2005.

Malhotra NR, Huang J, Schuster J: Hemorrhage into synovial cysts as a cause of acute radicular symptoms. AANS/CNS Section on disorders of the Spine and Peripheral Nerves Mar 2006.

Ramakrishna R, Malhotra NR, Burnett M, Maloney-Wilenksy E, Schuster S: Survival in patients with Glioblastoma Multiforme as a Function of Post-Operative Ambulation Status. Association of Neurological Surgeons Apr 2006.

Chen I, Malhotra NR, Levine J, LeRoux PD: Effect of Barbiturate Infusion on Cerebral Oxygenation. (Oral Presentation). Pennsylvania Neurosurgical Society Jul 2006.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: Injectable Hydrogels to Support Nucleus Pulposus Function: The Concept. (Oral Presentation). Pennsylvania Neurosurgical Society Jul 2006.

Chen I, Malhotra NR, Levine J, LeRoux PD: Barbiturate Infusion and Cerebral Oxygenation. Congress of Neurological Surgeons Oct 2006.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: Reversing Disc Degeneration via Restoration of Nucleus Pulposus Functional Mechanics. (Oral Presentation). Pan Philadelphia Neuroscience Meeting Jan 2007.

Cloyd J, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott D: Defining Unconfined Compression Modulus and Poisson’s Ratio for Human Nucleus Pulposus & Potential Nucleus Replacement Materials. Orthopedic Research Society Feb 2007.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: A Novel Injectable Nucleus Pulposus Implant Restores Range of Motion. The Spine Arthroplasty Society May 2007.

Malhotra NR, Beckstein J, Cloyd J, Chen W, Elliott DM: Restoration of Nucleus Pulposus Functional Mechanics via a Novel Injectable Implant. International Society for the Study off The Lumbar Spine (ISSLS) Jun 2007.

Heuer GG, Jeyamohan S, Malhotra NR, Zaghloul KA, Magge SN, Storm PB: Use of Expandable Cages in Pediatric Lumbar Burst Fractures. Pennsylvania Neurosurgical Society Jul 2007.

Malhotra NR, Beckstein J, Cloyd J, Chen W, Elliott DM: An In-situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. (Oral Presentation). International Meeting on Advanced Spinal Techniques (IMAST) Jul 2007.

Heuer GG, Magge SN, Jeyamohan S, Malhotra NR, Zaghloul KA, Storm PB: Use of Expandable Cages in Pediatric Lumbar Burst Fractures. Congress of Neurological Surgeons Sep 2007.

Malhotra NR, Beckstein J, Cloyd J, Chen W, Elliott DM: Criteria and Design Approach for Tissue Engineered Nucleus Pulposus Implants for Degenerative Disc Disease. Congress of Neurological Surgeons Sep 2007.

Heuer GG, Grant R, Shiveindra J, Malhotra NR, Whitmore R, Storm P, Schuster J: Treatment of High Thoracic Lesions via an Entirely Posterior Approach with Placement of Expandable Cages. Pennsylvania Neurosurgical Society Jul 2008.

Pennsylvania Neurosurgical Society: An In-Situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. (Oral Presentation). Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM Jul 2008.

Heuer GG, Grant RA, Jeyamohan S, Malhotra NR, Whitmore RG, Storm PB, Schuster J: Treatment of High Thoracic Lesions via an Entirely Posterior Approach with Placement of Expandable Cages. Congress of Neurological Surgeons Sep 2008.

O’Connell GD, Vresilovic EJ, Malhotra NR, Elliott DM: Discectomy Increases Internal Strains of the Disc Under Physiological Loads. The International Society for the Study of the Lumbar Spine (ISSLS) May 2009.

Malhotra NR, Thomas P, Grady MS: Injury to the Spine. Trauma: Contemporary Principles and Therapy. Flint L, Meredith JW, Schwalb CW, Trunkey DD, Rue LW, Taheri PA (eds.). Lippincott Williams & Wilkins, Philadelphia, PA Page: 297-304, 2008 Notes: Chapter 28.

Thomas P, Malhotra NR, Grady MS: Injury to the Spinal Cord Trauma: Contemporary Principles and Therapy. Flint, L., Meredith, W., Schwalb, W., Taheri, P., Trunkey, D. (Ed.) Lippincott Williams & Wilkins, Philadelphia, PA, USA. Page: 289-297, 2008 Notes: Chapter 27

Hwang SW, Malhotra NR, Shaffrey CI, Samdani AF: Intraoperative Neurophysiological Monitoring in Spine Deformity Surgery (Invited Review). Spine Deformity Sept 2012.

Plaha P, Malhotra NR, Heuer G, Whitfield P: Management of Chronic Subdural Hematoma (Invited Review). Advances in Clinical Neuroscience and Rehabilitation (ACNR) Nov 2008.

Cloyd Jordan M, Malhotra Neil R, Weng Lihui, Chen Weiliam, Mauck Robert L, Elliott Dawn M: Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 16(11): 1892-8, Nov 2007.

Neil R. Malhotra, M.D.: An In-Situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. Society Scientific Paper of the Year: Pennsylvania Neurosurgical Society Meeting, Hershey, PA. July 2008 Notes: Abstract presentation.

Malhotra NR, Thomas P, Grady MS: Injury to the Spine. Trauma: Contemporary Principles and Therapy. Flint L, Meredith JW, Schwalb CW, Trunkey DD, Rue LW, Taheri PA (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 297-304, 2008 Notes: Chapter 28.

Sanborn M, Smith LJ, Malhotra NR: Spinal Cord and Spinal Column. The Trauma Manual: Trauma and Acute Care Surgery 4th Edition. Peitzman AB, Yealy DM, Fabian TC, Rhodes M, Schwab CW (eds.). Lippincott Williams and Wilkins of Wolters Kluwer Health. ISBN-10: 1451116799; ISBN-13: 978-1451116793, Dec 2012 Notes: Chapter 25.

Malhotra NR, Whitfield P: Review of “The Legacy of Harvey Cushing.” Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8(3), 2008.

Thomas P., Malhotra, N.R., Grady M.S.: Injury to the Spinal Cord. Trauma: Contemporary Principles and Therapy. Flint, L., Meredith, W., Schwalb, W., Taheri, P., Trunkey, D. (Ed.) (eds.). Lippincott Williams & Wilkins, 2008.

Malhotra NR, Grady MS: Anterior Cervical Foraminotomy Technique. Spine Surgery: Tricks of the Trade, 2nd ed. Vacaro AR (eds.). Thieme Medical Publishers, Inc. Page: 54-56, 2009 Notes: Chapter 15.

Wendell LC, Khan A, Raser J, Lang SS, Malhotra N, Kofke WA, LeRoux P, Park S, Levine JM.: Successful management of refractory intracranial hypertension from acute hyperammonemic encephalopathy in a woman with ornithine transcarbamylase deficiency. Neurocrit Care. 13(1): 113-117, Aug 2010.

Malhotra Neil R, Shaffrey Christopher I: Intraoperative electrophysiological monitoring in spine surgery (Invited Review). Spine 35(25): 2167-79, Dec 2010.

Lega Bradley C, Danish Shabbar F, Malhotra Neil R, Sonnad Seema S, Stein Sherman C: Choosing the best operation for chronic subdural hematoma: a decision analysis. Journal of Neurosurgery 113(3): 615-21, Sep 2010.

Espinoza Orías Alejandro A, Malhotra Neil R, Elliott Dawn M: Rat disc torsional mechanics: effect of lumbar and caudal levels and axial compression load. The Spine Journal : official journal of the North American Spine Society 9(3): 204-9, Mar 2009.

Neil Malhotra, MD: "Medical Breakthrough: Spinal Surgery Today" Radio Interview with Dr. Lee Freedman. XM National Radio-ReachMD XM167: The Channel for Medical Professionals. Aug 2011.

Malhotra NR, Bhomick D, Hardesty D, Whitfield P: Intramedullary Spinal Cord Tumors: Diagnosis, Treatment and Outcomes (Invited Review). Advances in Clinical Neuroscience and Rehabilitation (ACNR) Sept 2010.

Malhotra NR: Costotransversectomy and Corpectomy for Solitary Spinal Metastases. Pennsylvania Neurosurgical Society Clinical Education and Evaluation Oct 2011.

Macyszyn L, Malhotra NR: Counterpoint: The Intensivist is in Charge. AANS Neurosurgeon 21(3), 2012.

Bohman LE, Malhotra NR: The Value of an “Infolded” Fellowship. AANS Neurosurgeon 21(3), 2012.

Sanborn MR, Abdullah K, Smith MJ, Grady MS, Malhotra NR: Improving Core Residency Education: An Argument for Increased Incorporation of Endovascular Surgical Training. AANS Neurosurgeon 21(4), 2012.

Lang SS, Malhotra NR: Interviewing for pediatric fellowship: Finding the right work-work balance. AANS Neurosurgeon 23(1), 2014.

Malhotra NR, Whitfield P: Review of “The Legacy of Harvey Cushing.” Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8(3), 2008.

Schuster JM, Malhotra NR: Posterior Thoracic Instrumentation. Youmans Neurological Surgery. Ed 6. Winn HR (Ed) (eds.). Saunders. Philadelphia, PA, USA. Page: 3061-3068, 2011, Page: 3061-3068, 2011 Notes: Chapter 301.

Kelz M, Malhotra NR: The Neurosurgical operative experience, a patients perspective. WHYY “The Pulse”, Host: Maiken Scott Jan 2014.

Malhotra NR: The Effect of July Admission on Inpatient Outcomes Following Spinal Surgery.McDonald JS, Clarke MJ, Helm GA, Kallmes DF. Medscape Neurology January 2013 Notes: Invited Editorial.

Malhotra NR: Health-Real Life Drama: Neurosurgeon saves spinal cord and a patient walks again. CBS 3 Television News, Sweeps Week May 2014 Notes: Invited Television Broadcast Interview.

Malhotra NR, Schuster JM, O’Rourke DM: Best of both worlds. Suburban Life, Main Line, Delaware County magazine. Author: Hengel A 5(10), 2014.

Malhotra NR: Penn medicine expert offers new options for brain and spinal conditions. Chestnut Hill local Aug 2013 Notes: Invited Newspaper Interview.

Malhotra, NR: Functional regeneration the human degenerative disc. (Oral Presentation). Academy of Neurological Surgery September 2014.

Malhotra NR, Lotier L, Becker W, Smith LJ: Using EpicCare ambulatory to support precision medicine, QI, and research. (Oral Presentation). Epic International Physician Advisory Council September 2014.

Showalter BL, Elliott DM, Malhotra NR: Injectable Hydrogel Treatment Stabilizes Human Disc Range of Motion Under Physiologic Cyclic Loading. (Special Poster Presentation). The International Society for the Study of the Lumbar Spine (ISSLS) June 2014.

Malhotra NR, Grady MS: An EMR embedded, clinical information acquisition system enhances care, research, and quality improvement. (Oral Presentation). Neurosurgical Society of America June 2014 Notes: St. Andrews-by-the-Sea, New Brunswick, Canada.

Smith LJ, Chiaro JC, O'Donnell P, Ponder KP, Malhotra NR, Elliott DM, Shore EM, Haskins ME: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Mckay Orthopedics Research Symposium June 2014.

Milby AH, Showalter BL, Haughan J, Mauck RL, Elliott DM, Malhotra NR, Schaer TP, Smith LJ: Percutaneous Delivery of Chondroitinase ABC Induces Moderate Disc Degeneration in a Goat Model. McKay Orthopedics Research Symposium June 2014.

Lewis DJ, Malhotra NR, Burnett MG, Attiah MA, Bailey RL, Stein SC: Comparative Effectiveness of Anterior Cervical Discectomy (With and Without Fusion) and Arthroplasty in Single-Level Disc Disease: A Decision Analysis American Association of Neurological Surgeo April 2014.

Malhotra NR, Chiaro JA, O’Donnell P, Ponder KP, Haskins ME, Smith LJ: Combined Neonatal Enzyme Replacement Therapy and Simvastatin for Treatment of Cervical Spine Intervertebral Disc Disease in Mucopolysaccharidosis I Dogs. (Oral Presentation). American Association of Neurological Surgeons April 2014.

Showalter BL, Amin DB, Marcozzi AN, Elliott DM, Malhotra NR: Injectable Hydrogel Treatment Stabilizes Human Disc Mechanical Function Under Physiologic Cyclic Loading. Orthopedic Research Society March 2014.

Milby AH, Showalter BL, Haughan J, Mauck RL, Elliott DM, Malhotra NR, Schaer TP, Smith LJ: Percutaneous Delivery of Chondroitinase ABC Induces Moderate Disc Degeneration in a Goat Model. Orthopedic Research Society March 2014.

Smith LJ, Chiaro JA, McKee KK, Mauck RL, Malhotra NR, Harfe BD: Deep Sequencing of Notochord-Derived Cells During Embryonic Formation of the Nucleus Pulposus (Oral Presentation). Orthopedic Research Society March 2014.

Chiaro JA, O'Donnell P, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Combined Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Intervertebral Disc Disease in Mucopolysaccharidosis I. Orthopedic Research Society March 2014.

Smith LJ, Chiaro JA, O'Donnell P, Ponder KP, Malhotra NR, Elliott DM, Shore EM, Haskins ME: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Lysosomal Disease Network's World Symposium Feb 2014.

Milby AH, Attiah M, Massey P, Malhotra NR, Stein SC: Surgical management of cervical myelopathy due to ossification of the posterior longitudinal ligament: a decision analysis (Oral Presentation). Cervical Spine Research Society Dec 2013.

Showalter BL, Elliott DM, Malhotra NR: Hydrogel Implant restores human disc mechanics under physiologic cyclic loading following nucleotomy.(Oral Presentation). International Philadelphia Spine research Society Nov 2013.

Showalter BL, Amin DB, Marcozzi AN, Elliott DM, Malhotra NR: Injectable Hydrogel Treatment Stabilizes Human Disc Mechanical Function Under Physiologic Cyclic Loading. (Oral Presentation). Penn Center for Musculoskeletal Disorders Symposium Nov 2013.

Chiaro JC, O'Donnell P, Shore EM, Malhotra NR, Elliott DM Ponder KP, Haskins ME, Smith LJ : Neonatal Enzyme Replacement Therapy Attenuates Cervical Spine Bone and Disc Disease in Mucopolysaccharidosis I Dogs. International Philadelphia Spine Research Symposium Nov 2013.

Smith LJ, Chiaro JA, McKee KK, Mauck RL, Malhotra NR, Harfe BD: Deep Sequencing of Notochord-Derived Cells During Embryonic Formation of the Nucleus Pulposus: Preliminary Findings.(Oral Presentation). International Philadelphia Spine Research Symposium Nov 2013.

Smith LJ, Chiaro JC, Ponder KP, Malhotra NR, Elliott DM, Shore EM, Haskins ME: Neonatal Enzyme Replacement Therapy Attenuates Vertebral Bone Disease in the Cervical Spines of Mucopolysaccharidosis I Dogs.(Oral Presentation)(Young Investigator Award winner). American Society for Bone and Mineral Research Oct 2013.

Shaffrey CI, Smith JS, Mummaneni PV, Ziewacz J, Cheng JS, Whitmore RG, Ghogawala Z, Malhotra NR, Magge S, Asher AL, Resnick D, Knightly J, Kaiser M, Abbed K, Heary RF: Establishing the Efficacy of Lumbar Discectomy and Single Level Fusion for Spondylolisthesis -Experience with the AANS’ NeuroPoint SD Registry. (Oral Presentation). International Meeting on Advanced Spine Techniques (IMAST) Jul 2013.

Gorth DJ, Martin JT, Elliott DM, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: In Vivo Retention and bioactivity of IL-1RA Microspheres in the Rat Caudal Intervertebral Disc. International Society for the Study of the Lumbar Spine May 2013.

Sanborn MR, Malhotra NR, Carr B, Kalian M, Grady MS, Stein SC: Endovascular Interventions and Duty Hour Restrictions Drastically Reduce Aneurysm Clip Ligation Experience by US Trainees. SNIS International Endovascular Stroke Conference and Joint Cerebrovascular Section Feb 2013.

Gorth DJ, Martin JT, Dodge GR, Hebela N, Malhotra NR, Mauck RL, Elliott DM, Smith LJ: In Vivo Delivery of IL-1ra from PLGA Microspheres Prevents IL-1b Induced Glycosaminoglycan Loss in the Rat Caudal Intervertebral Disc. ASME global conference for nano engineering for medicine and biology (NEMB) Feb 2013.

Gorth, DJ, Elliott, DM, Mauck RL, Chen, W, Smith, LJ, Malhotra NR: Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. Orthopedic Research Society Jan 2013.

Gorth DJ, Elliott DM, Mauck RL, Chen W, Smith LJ, Malhotra NR: Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. Philadelphia Spine Symposium Nov 2012.

Showalter BL, Malhotra NR, Elliott DM: Nucleotomy alters mechanical response of human discs undergoing cyclic loading and hydrated recovery. (Oral Presentation). Philadelphia Spine Symposium Nov 2012.

Smith LJ, Gorth DJ, Chiaro JA, Martin JT, Dodge GR, Malhotra NR, Hebela NM, Mauck RL, Elliott DM: Targeting inflammation in intervertebral disc degeneration (Oral Presentation). International Symposium on Nanomedicine in Drug Delivery and Cancer Diagnosis Aug 2012.

Sanborn MR, Pisapia J, Carr M, Stein SC, Grady MS, Malhotra NR: Resident Training: The impact of duty hours and the rise of endovascular neurosurgery on resident operative experience. Pennsylvania Neurosurgical Society Jul 2012.

Koch M, Chen I, Lang SS, Mcgill-Armento K, Palella J, Pasao N, Malhotra NR: Initial Experience with Outpatient One-Level Lumbar Discectomy. (Oral Presentation). Pennsylvania Neurosurgical Society Jul 2012.

Showalter BL, MacLean IS, Elliott DM, Malhotra NR: Nucleotomy alters mechanical function following cyclic loading and unloaded recovery of human discs. (Oral Presentation). American Society of Mechanical Engineering Jun 2012.

McGill-Aremento K, Palella JM, Pasao NP, Gardiner D, Chen HI, Rupich K, Maloney E, Malhotra NR: Lumbar Discectomy Surgery as an Outpatient Procedure. A Paradigm Shift. American Association of Nurse Practitioners Jun 2012.

Clement RC, Kallan MJ, Carr BG, Reilly PM, Malhotra NR: Neurotrauma: Who Should Treat and Who Should Transfer? American Association of Neurological Surgeons May 2012.

Ghogawala Z, Shaffrey CI, Asher AL, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Heary RF, Abbed KM, Sciubba DM, Resnick DK: The Efficacy of Lumbar Discectomy and Single Level Fusion for Spondylolisthesis: Neuropoint SD Registry Results. (Oral Presentation). American Association of Neurological Surgeons Apr 2012.

Showalter BL, Milby AH, Haughan J, Mauck RL, Elliott DM, Malhotra NR, Schaer TP, Smith LJ: Percutaneous Delivery of Chondroitinase ABC for Initiation of Disc Degeneration in a Goat Model. American Association of Neurological Surgeons May 2014.

Showalter BL, Elliott DM, Chen W, Smith LJ, Malhotra NR: Hydrogel implant stabilizes human disc mechanics under physiologic cyclic loading following nucleotomy. American Association of Neurological Surgeons May 2014.

Ghogawala Z, Shaffrey CI, Asher AL, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Heary RF, Abbed KM, Sciubba DM, and Resnick DK: The Design and Development of the Neuropoint SD Spine Registry for Lumbar Discectomy and Single Level Fusion for Spondylolisthesis.(Oral Presentation). AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Mar 2012.

Gerasimowicz KM, Yoder JH, Tustison NJ, Song G, O’Connell G, Malhotra NR, Vresilovic EJ, Wright AC, Gee JC, Elliott DM: Optimization of Image Registration and Application to Human Disc Mechanics with Nucleotomy (Oral Presentation). Northeast Bioengineering Apr 2011.

Malhotra NR, Han W, Beckstein J, Cloyd J, Chen W, Elliott DM: An injectable Nucleus Pulposus Implant to Restore Spinal Range of Motion in Compression. Orthopeadic Research Society Jan 2011.

Welch WC, Tambi V, Sestokas AK, Dante SJ, Malhotra NR, Schwartz DM: Neurophysiological Detection and Reversal of Evolving Ishemic Injury During da Vinci Robot Assisted Anterior Lumbar Spinal Surgery. (Oral Presentation). BIT World Congress Jan 2010.

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Last updated: 10/10/2014
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