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Allan I. Pack
Allan I. Pack, M.B.Ch.B., Ph.D.
John Miclot Professor
Department: Medicine
Graduate Group Affiliations
Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Fax: 215-746-4814
Email:
PACK@MAIL.MED.UPENN.EDU
PACK@MAIL.MED.UPENN.EDU
Publications
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Permanent linkM.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Description of Research Expertise
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.Selected Publications
Fedson, A.C., Pack, A.I., and Gislason, T.: Frequently used sleep questionnaires in epidemiological and genetic research for obstructive sleep apnea: A review. Sleep Medicine Reviews 16(6): 529-537, Dec 2012.Maislin, G., Ahmed, M.M., Gooneratne, N., Thorne-Fitzgerald, M., Kim, C., Teff, K., Arnardottir, E.S., Benediktsdottir, B., Einarsdottir, H., Juliusson, S., Pack, A.I., Gislason, T., and Schwab, R.: Single slice vs. volumetric MR assessment of visceral adipose tissue: reliability and validity among the overweight and obese. Obesity 10(10): 2124-2132, Oct 2012.
Arnardottir, E.S., Maislin, G., Jackson, N., Schwab, R.J., Benediktsdottir, B., Teff, K., Juliusson, S., Pack, A.I. and Gislason, T.: The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study. International Journal of Obesity Sep 2012 Notes: Sep 11 doi:10.1038/ijo.2012.218 [Epub ahead of print]
Arnardottir, E.S., Maislin, G., Schwab, R.J., Staley, B., Benediktsdottir, B., Olafsson, I., Juliusson, S., Romer, M., Gislason, T. and Pack, A.I.: The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the Icelandic Sleep Apnea Cohort. Sleep 35(7): 921-932, Jul 2012.
Onksen, J.L., Briand, L.A., Galante, R.J., Pack, A.I. and Blendy, J.A.: Running-induced anxiety is dependent on increases in hippocampal neurogenesis. Genes, Brain and Behavior 11(5): 529-538, Jul 2012.
Watson, N.F., Harden, K.P., Buchwald, D., Vitiello, M.V., Pack, A.I., Weigle, D.S., and Goldberg, J.: Sleep duration and body mass index in twins: a gene-environment interaction. Sleep 35(5): 597-603, May 2012.
Naidoo, N., Ferber, M., Galante, R.J., McShane, B,, Hu. J.H., Zimmerman, J., Maislin, G., Cater, J., Wyner, A., Worley, P. and Pack, A.I.: Role of Homer proteins in the maintenance of sleep-wake states. PloS One 7(4): e35174, Apr 2012.
Björnsdóttir, E., Janson, C., Gíslason, T., Sigurdsson, J.F., Pack, A.I., Gehrman, P., and Benediktsdóttir, B.: Insomnia in untreated sleep apnea patients compared to controls. Journal of Sleep Research 21(2): 131-138, Apr 2012.
Zimmerman, J.E., Chan, M.T., Jackson, N., Maislin, G., and Pack, A.I.: Genetic background has a major impact on differences in sleep resulting from environmental influences in Drosophila. Sleep 35(4): 545-557, Apr 2012.
McShane, B.B., Galante, R.J., Biber, M., Jensen, S.T., Wyner, A.J., and Pack, A.I.: Assessing REM sleep in mice using video data. Sleep 35(3): 433-442, Mar 2012.
