Allan I. Pack
Allan I. Pack, M.B.Ch.B., Ph.D.
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Description of Research ExpertiseDr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Description of Clinical ExpertiseDr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).
Selected PublicationsPellegrino, R., Kavakli, I.H., Goel, N., Cardinale, C.J., Dinges, D.F., Kuna, S.T., Maislin, G., Van Dongen, H.P.A., Tufik, S., Hogenesch, J.B., Hakonarson, H. and Pack, A.I.: A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep 2014 (in press).
Sutherland, K., Schwab, R.J., Maislin, G., Lee, R.W.W., Benedikstdottir, B., Pack, A.I., Gislason, T., Juliusson, S. and Cistulli, P.A.: Facial phenotyping by quantitative photography reflects craniofacial morphology measured on MRI in Icelandic sleep apnea patients. Sleep 2014 (in press).
Watson, N.F., Harden, K.P., Buchwald, D., Vitiello, M.V., Pack, A.I., Strachan, E. and Goldberg, J.: Sleep duration and depressive symptoms: a gene-environment interaction. Sleep 37(2): 351-258, 2014.
Bjornsdottir, E., Janson, C., Sigurdsson, J.F., Gehrman, P., Perlis, M., Juliusson, S., Arnardottir, E.S., Kuna, S.T., Pack, A.I., Gislason, T. Benediktsdottir, B.: Symptoms of insomnia among patients with obstructive sleep apnea before and after two years of positive airway pressure treatment. Sleep 36(12): 1901-1909, Dec 2013.
Brown, M.K., Chan, M.T., Zimmerman, J.E., Pack, A.I., Jackson, N.E. and Naidoo, N.: Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis. Neurobiology of Aging Dec 2013 Notes: pii: S0197-4580(13)00630-1. doi: 10.1016/j.neurobiolaging.2013.12.005. [Epub ahead of print]
Wimmer, M.E., Rising, J., Galante, R.J., Wyner, A., Pack, A.I. and Abel, T.: Aging in mice reduces the ability to sustain sleep/wake states. PLoS One 8(12): e81880, Dec 2013.
Lim, M.M., Elkind, J., Xiong, G., Galante, R., Zhu, J., Zhang, L., Lian, J., Rodin, J., Kuzma, N.N., *Pack, A.I. and *Cohen, A.S. (*co-senior authors): Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury. Science Translational Medicine 5(215): 215ra173, Dec 2013.
Pien, G.W., Pack, A.I., Jackson, N., Macones, G.A. and Schwab, R.J.: Risk factors for sleep-disordered breathing in pregnancy. Thorax Nov 2013 Notes: doi: 10.1136/thoraxjnl-2012-202718. [Epub ahead of print]
Arnardottir, E.S., Janson, C., Bjornsdottir, E.M., Benediktsdottir, B., Juliusson, S., Kuna, S.T., Pack, A.I. and Gislason, T.: Nocturnal sweating—a common symptom of obstructive sleep apnoea: the Icelandic Sleep Apnoea Cohort. BMJ Open 3(5), May 2013 Notes: doi:pii: e002795. 10.1136/bmjopen-2013-002795. Print 2013.
Anafi, R.C., Pellegrino, R., Shockley, K.R., Romer, M., Tufik, S. and Pack, A.I.: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues. BMC Genomics 14(1): 362, May 2013.