Perelman School of Medicine at the University of Pennsylvania

Center for Sleep and Circadian Neurobiology

faculty photo

Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

John Miclot Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Xu, L., Xie, D., Griffin, K.S., Staley, B., Wang, Y., Nichols, D.A., Benca, R.M., Pack, A.I., Redline, S., Walsh, J.K., Kushida, C.A., and Kuna, S.T.: Objective adherence to dental device versus positive airway pressure treatment in adults with obstructive sleep apnea. Journal of Sleep Research 30(4): e13240, Aug 2021 Notes: doi: 10.1111/jsr.13240.

Li, S., Yu, L., Dong, X., Zhang, X., Keenan, B.T., Han, F., Bi, T., Chang, Y., Yu, Y., Zhou, B., Pack, A.I., and Kuna, S.T.: Home sleep apnea testing of adults with chronic heart failure. Journal of Clinical Sleep Medicine 17(7): 1453-1463, Jul 2021 Notes: doi: 10.5664/jcsm.9224.

Keenan, B.T., Webster, J.C., Wiemken, A.S., Lavi-Romer, N., Nguyen, T., Svenson, K.L., Galante. R.J., Churchill, G.A., Pickup, S., Pack, A.I., and Schwab, R.J.: Heritability of fat distributions in the in male mice from the founder strains of Diversity Outbred mice. G3 (Bethesda) 11(5): jkab079, May 2021 Notes: doi: 10.1093/g3journal/jkab079.

Qin, H., Keenan, B.T., Mazzotti, D.R., Vaquerizo-Villar, F., Kraemer, J.F., Wessel, N., Tufik, S., Bittencourt, L., Cistulli, P.A., de Chazal, P., Sutherland, K., Singh, B., Pack, A.I., Chen, N.H., Fietze, I., Gislason, T., Holfinger, S., Magalang, U.J., and Penzel, T.: Heart rate variability during wakefulness as a marker of obstructive sleep apnea severity. Sleep 44(5): zsab018, May 2021 Notes: doi: 10.1093/sleep/zsab018.

Goldschmied, J.R., Lacourse, K., Maislin, G., Delfrate, J., Gehrman, P., Pack, F.M., Staley, B., Pack, A.I., Younes, M., Kuna, S.T., and Warby, S.C.: Spindles are highly heritable as identified by different spindle detectors. Sleep 44(4): zsaa230, Apr 2021 Notes: doi: 10.1093/sleep/zsaa230.

Malone, S.K., Patterson, F., Grunin, L., Melkus, G.D., Riegel, B., Punjabi, N., Yu, G., Urbanek, J., Craniceanu, C., and Pack, A.: Habitual physical activity patterns in a nationally representative sample of U.S. adults. Translational Behavioral Medicine 11(2): 332-341, Mar 2021.

Xu, L., Keenan, B.T., Maislin, D., Gislason, T., Benediktsdóttir, B., Gudmundsdóttir, S., Gardarsdottir, M., Staley, B., Pack, F.M., Guo, X., Feng, Y., Chahwala, J., Manaktala, P., Hussein, A., Reddy-Koppula, M., Hashmath, Z., Lee, J., Townsend, R.R., Schwab, R.J., Pack, A.I., Kuna, S.T., and Chirinos, J.A.: Effect of obstructive sleep apnea and positive airway pressure therapy on cardiac remodeling as assessed by cardiac biomarker and magnetic resonance imaging in nonobese and obese adults. Hypertension 77: 980-992, Mar 2021.

Chaggar, G., Sutherland, K., Han, F., Fietze, I., Penzel, T., Benediktsdóttir, B., Gislason, T., Magalang, U., Pack, A.I., Singh, B., McArdle, N., Bittencourt, L., Li, Q.Y., Chen, N.H., de Chazal, P., Cistulli, P.A., and Bin, Y.S.: Is snoring during pregnancy a predictor of later life obstructive sleep apnoea? A case-control study. Sleep Medicine 79: 190-194, Mar 2021.

Malhotra, A., Ayappa, I., Ayas, N., Collop, N., Kirsch, D., McArdle, N., Mehra, R., Pack, A.I., Punjabi, N., White, D.P., Gottlieb, D.J. for SRS task force: Metrics of sleep apnea severity: beyond the apnea-hypopnea index. Sleep Page: zsab030, Mar 2021 Notes: doi: 10.1093/sleep/zsab030.

Pack, A.I., Magalang, U.J., Singh, B., Kuna, S.T., Keenan, B.T., and Maislin, G.: Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias. Sleep 44(2): zsaa229, Feb 2021 Notes: doi: 10.1093/sleep/zsaa229.

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Last updated: 09/24/2021
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