faculty photo

Douglas C Wallace

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 6060
3501 Civic Center Blvd
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
Education:
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
Permanent link
 

Selected Publications

Lin, R. Angelin, A. Da Settimo, F. Martini, C. Taliani, S. Zhu, S. Wallace, D C.: Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration. Aging Cell 13(3): 507-518, Jun 2014.

Golomb, B A. Erickson, L C. Scott-Van Zeeland, A A. Koperski, S. Haas, R H. Wallace, D C. Naviaux, R K. Lincoln, A J. Reiner, G E. Hamilton, G.: Assessing Bioenergetic Compromise in Autism Spectrum Disorder With P-31 Magnetic Resonance Spectroscopy: Preliminary Report Journal of Child Neurology 29(2): 187-193, Feb 2014.

Kenney, M C. Chwa, M. Atilano, S R. Falatoonzadeh, P. Ramirez, C. Malik, D. Tarek, M. Del Carpio, J C. Nesburn, A B. Boyer, D S. Kuppermann, B D. Vawter, M P. Jazwinski, S M. Miceli, M V. Wallace, D C. Udar, N.: Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases Biochimica Et Biophysica Acta-Molecular Basis of Disease 1842(2): 208-219, Feb 2014.

Lampe, J W. Da, T. Selak, M A. McManus, M J. Wallace, D C. Becker, L B. : Critical Role For Intra-mitochondrial NADPH Generation For Survival After Cardiac Arrest: Studies In The Nicotinamide Nucleotide Transhydrogenase Deficit Mouse Circulation 128(22), Nov 2013.

Zand, K. Pham, T. Davila, A. Wallace, D C. Burke, P.: Trapping and study of individual mitochondria using nanofluidic technology. Mitochondrion 13(6): 943, Nov 2013.

Chalkia, D. Lowery, R. Derbeneva, O. Lvova, M. Sing, C. Shimmin, L. Hixson, J. Simham, H. Wadhwa, P. Wallace, D C.: Preterm birth is associated with mitochondrial DNA variation. Mitochondrion 13(6): 929-930, Nov 2013.

Picard, M. Gentil, B J. McManus, M J. White, K. St Louis, K. Gartside, S E. Wallace, D C. Turnbull, D M.: Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle Source of Applied Physiology 115(10): 1562-1571, Nov 2013.

Ortiz-Gonzaley, X R. Mills, J A. Wallace, D C.: Modeling mitochondrial cardiomyopathy using human ANT1 deficient iPSC-derived cardiomyocytes Mitochondrion 13(6): 941-942, Nov 2013.

Xu, S Q. Vu, N H T. Chao, E. Simon, M. Zoleikhaeian, M. Kimonis, V. Huang, T S. Mozaffar, T. Wallace, D C.: Summary of the mitochondrial findings in a series of 300 cases. Mitochondrion 13(6): 936-937, Nov 2013.

Wallace, D C. Chalkia, D.: Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease Cold Spring Harbor Perspectives in Biology 5(11), Nov 2013.

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Last updated: 06/05/2014
The Trustees of the University of Pennsylvania