faculty photo

Douglas C Wallace

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
Permanent link

Selected Publications

Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski P, Seifert E, McEwen BS, Wallace DC.: Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proceedings of the National Academy of Sciences 112(48), Dec 2015 Notes: PMID: 26627253 PMCID: PMC4672794

Wallace DC: Mitochondrial DNA Variation in Human Radiation and Disease. Cell 163(1): 33-38, Sep 2015 Notes: PMID: 26406369.

Atilano SR, Malik D, Chwa M, Cáceres-Del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC.: Mitochondrial DNA variants can mediate methylation sttus of inflammation, angiogenesis and signaling genes. Human Molecular Genetics Aug 2015 Notes: PMID: 25964427; PMCID: PMC4512622.

Lin R, Rittenhouse D, Sweeney K, Potluri P, Wallace DC.: TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila. PLoS Genetics 11(8), Aug 2015 Notes: PMID: 26241038; PMCID: PMC4524697

Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC.: Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal 8(389), Aug 2015 Notes: PMID: 26268608; PMCID: PMC4539531.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.: Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours. Nature Communications Jun 2015 Notes: PMID: 26085380.

Kilbaugh TJ, Lvova M, Karlsson M, Zhang Z, Leipzig J, Wallace DC, Margulies SS.: Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model. PLos One 10(6), Jun 2015 Notes: PMID: 26098565; PMCID: PMC4476697.

Simon M, Richard EM, Wang X, Shahzad M, Huang VH, Qaiser TA, Potluri P, Mahl SE, Davila A, Nazli S, Hancock S, Yu M, Gargus J, Chang R, Al-Sheqaih N, Newman WG, Abdenur J, Starr A, Hegde R, Dorn T, Busch A, Park E, Wu J, Schwenzer H, Flierl A, Florentz C, Sissler M, Khan SN, Li R, Guan MX, Friedman TB, Wu DK, Procaccio V, Riazuddin S, Wallace DC, Ahmed ZM, Huang T, Riazuddin S.: Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome. PLoS Genetics Mar 2015 Notes: PMID: 25807530; PMCID: PMC4373692

Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, Sims CA, Baur JA, Wallace DC, Hancock WW.: Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival. Federation of American Societies for Experimental Biology Journal Feb 2015 Notes: PMID: 25681462.

Picard M, McManus MJ, Csordás G, Várnai P, Dorn GW 2nd, Williams D, Hajnóczky G, Wallace DC.: Trans-mitochondrial coordination of cristae at regulated membrane junctions. Nature Communications Feb 2015 Notes: PMID: 25687472; PMCID: PMC4332397

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Last updated: 05/23/2016
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