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Douglas C Wallace

Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Contact information

The Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 6060
3501 Civic Center Blvd
Philadelphia, PA 19104-4302

Office: 267-425-3034
Fax: 267-303-3615

Education:
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.

Post-Graduate Training
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.

Permanent link

Selected Publications

Falk M J. Pierce E A. Consugar M. Xie M H. Guadalupe M. Hardy O. Rappaport E F. Wallace D C. LeProust E. Gai X. : Mitochondrial disease genetic diagnostics: optimized whole-exome analysis for all mitocarta nuclear genes and the mitochondrial genome. Discov Med 14(79): 389-99, Dec 2012

Lin, C S. Sharpley, M S. Fan, W. Waymire, K G. Sadun, A A. Carelli, V. Ross-Cisneros, F N. Baciu, P. Sung, E. McManus, M J. Pan, B X. Gil, D W. Macgregor, G R. Wallace, D C.: Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci 4(109): 20065-20070, Dec 2012 Notes: doi: 10.1073/pnas.1217113109. Epub 2012 Nov 5.

Zhang, C. Huang, V H. Simon, M. Sharma, L K, Fan, W. Haas, R. Wallace, D C. Bai, Y. Huang, T.: Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions. FASEB J 26(12): 4914-4924, Dec 2012 Notes: doi: 10.1096/fj.12-206532. Epub 2012 Aug 27.

Falk, M J. Pierce, E A. Consugar, M. Xie, M H. Guadalupe, M. Hardy, O. Rappaport, E F. Wallace, D C. Leproust, E. Gai, X. : Mitochondrial disease genetic diagnostics: optimized whole-exome analysis for all MitoCarta nuclear genes and the mitochondrial genome. Discov Med 14(79): 389-399, Dec 2012.

Fielder, T J. Yi, C S. Masumi, J. Waymire, K G. Chen, H W. Wang, S. Shi, K X. Wallace, D C. Macgregor, G R.: Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts. Transgenic Res 21(6): 1149-1158, Dec 2012 Notes: doi: 10.1007/s11248-012-9605-3. Epub 2012 Mar 16.

Sharpley, M S. Marciniak, C. Eckel-Mahan, K. McManus, M. Crimi, M. Waymire, K. Lin, C S. Masubuchi, S. Friend, N. Koike, M. Chalkia, D. MacGregor, G. Sassone-Corsi, P. Wallace, D C. : Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell 151(2): 333-343, Oct 2012 Notes: doi: 10.1016/j.cell.2012.09.004.

Wallace, D C.: Mitochondria and cancer. Nat Rev Cancer 12(10): 685-698, Oct 2012 Notes: doi: 10.1038/nrc3365.

Elson, J L. Sweeney, M G. Procaccio, V. Yarham, J W. Salas, A. Kong, Q P. van der Westhuizen, F H. Pitceathly, R D. Thorburn, D R. Lott, M T. Wallace, D C. Taylor, R W. McFarland, R.: Toward a mtDNA locus-specific mutation database using the LOVD platform. Human Mutation 33(9): 1352-1358, Sept 2012 Notes: doi: 10.1002/humu.22118. Epub 2012 Jul 2.

Lim, T S. Davila, A Jr., Wallace, D C. Burke, P J. : Wafer-scale mitochondrial membrane potential assays. Lab on a Chip 12(15): 2719-2725, Aug 2012 Notes: doi: 10.1039/c2lc40086c. Epub 2012 May 25.

Desquiret-Dumas, V. Gueguen, N. Barth, M. Chevrollier, A. Hancock, S. Wallace, D C. Amati-Bonneau, P. Henrion, D. Bonneau, D. Reynier, P. Procaccio, V.: Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS. Biochimica et Biophysica Acta 1822(6): 1019-1029, Jun 2012 Notes: doi: 10.1016/j.bbadis.2012.01.010. Epub 2012 Jan 28.