faculty photo

Douglas C Wallace

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 6060
3501 Civic Center Blvd
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
Permanent link

Selected Publications

Atilano SR, Malik D, Chwa M, Cáceres-Del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC.: Mitochondrial DNA Variants Can Mediate Methylation Status of Inflammation, Angiogenesis and Signaling Genes. Human Molecular Genetics May 2015 Notes: PMID: 25964427

Simon M, Richard EM, Wang X, Shahzad M, Huang VH, Qaiser TA, Potluri P, Mahl SE, Davila A, Nazli S, Hancock S, Yu M, Gargus J, Chang R, Al-Sheqaih N, Newman WG, Abdenur J, Starr A, Hegde R, Dorn T, Busch A, Park E, Wu J, Schwenzer H, Flierl A, Florentz C, Sissler M, Khan SN, Li R, Guan MX, Friedman TB, Wu DK, Procaccio V, Riazuddin S, Wallace DC, Ahmed ZM, Huang T, Riazuddin S.: Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome. PLoS Genetics Mar 2015 Notes: PMID: 25807530; PMCID: PMC4373692

Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, Sims CA, Baur JA, Wallace DC, Hancock WW.: Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival. Federation of American Societies for Experimental Biology Journal Feb 2015 Notes: PMID: 25681462.

Picard M, McManus MJ, Csordás G, Várnai P, Dorn GW 2nd, Williams D, Hajnóczky G, Wallace DC.: Trans-mitochondrial coordination of cristae at regulated membrane junctions. Nature Communications Feb 2015 Notes: PMID: 25687472; PMCID: PMC4332397

Falk MJ, Shen L, Gonzalez M, Leipzig J, Lott MT, Stassen AP, Diroma MA, Navarro-Gomez D, Yeske P, Bai R, Boles RG, Brilhante V, Ralph D, DaRe JT, Shelton R, Terry SF, Zhang Z, Copeland WC, Van Oven M, Prokisch H, Wallace DC, Attimonelli M, Krotoski D, Zuchner S, Gai X. : Mitochondrial Disease Sequence Data Resource (MSeqDR): A global grass-roots consortium to facilitate deposition, curation, annotation, and integrated analysis of genomic data for the mitochondrial disease clinical and research communities. Molecular Genetics and Metabolism 14(00377-1): s1096-7192, Dec 2014 Notes: PMID: 25542617

Navarro-Gomez D, Leipzig J, Shen L, Lott M, Stassen AP, Wallace DC, Wiggs JL, Falk MJ, van Oven M, Gai X. : Phy-Mer: a novel alignment-free and reference-independent mitochondrial haplogroup classifier. Bioinformatics 31(8), Dec 2014 Notes: PMID: 25505086; PMCID: PMC4393525.

Picard M, Zhang J, Hancock S, Derbeneva O, Golhar P, Golik P, O'Hearn S, Levy S, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce IA, Procaccio V, Wallace DC.: Progressive Increase in mtDNA 3243A>G Heteroplasmy Causes Abrupt Transcriptional Reprogramming. Proceedings of the National Academy of Sciences of the United States of America 111(38): E4033--E4042, Sep 2014 Notes: PMID: 25192935; PMCID: PMC4183335

Cristina Kenney M, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Vawter M, Jazwinski SM, Miceli M, Wallace DC, Udar N: Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. Human Molecular Genetics 23(13): 3537-3551, Jul 2014 Notes: PMID: 24584571; PMCID: PMC4049308.

Malik D, Hsu T, Falatoonzadeh P, Cáceres-del-Carpio J, Tarek M, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC. : Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases. PLOS ONE 11(9): e99003, Jun 2014 Notes: PMID: 24919117; PMCID: PMC4053329

Lin R, Angelin A, Da Settimo F, Martini C, Taliani S, Zhu S, Wallace DC.: Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration. Aging Cell 13(3): 507-518, Jun 2014 Notes: PMID: 24977274; PMCID: PMC4076708.

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Last updated: 06/11/2015
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