faculty photo

Douglas C Wallace

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 6060
3501 Civic Center Blvd
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
Permanent link

Selected Publications

Falk MJ, Shen L, Gonzalez M, Leipzig J, Lott MT, Stassen AP, Diroma MA, Navarro-Gomez D, Yeske P, Bai R, Boles RG, Brilhante V, Ralph D, DaRe JT, Shelton R, Terry SF, Zhang Z, Copeland WC, Van Oven M, Prokisch H, Wallace DC, Attimonelli M, Krotoski D, Zuchner S, Gai X. : Mitochondrial Disease Sequence Data Resource (MSeqDR): A global grass-roots consortium to facilitate deposition, curation, annotation, and integrated analysis of genomic data for the mitochondrial disease clinical and research communities. Molecular Genetics and Metabolism 14(00377-1): s1096-7192, Dec 2014 Notes: PMID: 25542617

Navarro-Gomez D, Leipzig J, Shen L, Lott M, Stassen AP, Wallace DC, Wiggs JL, Falk MJ, van Oven M, Gai X. : Phy-Mer: a novel alignment-free and reference-independent mitochondrial haplogroup classifier. Bioinformatics Dec 2014 Notes: PMID: 25505086.

Picard M, Zhang J, Hancock S, Derbeneva O, Golhar P, Golik P, O'Hearn S, Levy S, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce IA, Procaccio V, Wallace DC.: Progressive Increase in mtDNA 3243A>G Heteroplasmy Causes Abrupt Transcriptional Reprogramming. Proceedings of the National Academy of Sciences of the United States of America 111(38): E4033--E4042, Sep 2014 Notes: PMID: 25192935; PMCID: PMC4183335

Cristina Kenney M, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Vawter M, Jazwinski SM, Miceli M, Wallace DC, Udar N: Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. Human Molecular Genetics 23(13): 3537-3551, Jul 2014 Notes: PMID: 24584571; PMCID: PMC4049308.

Malik D, Hsu T, Falatoonzadeh P, Cáceres-del-Carpio J, Tarek M, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC. : Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases. PLOS ONE 11(9): e99003, Jun 2014 Notes: PMID: 24919117; PMCID: PMC4053329

Lin R, Angelin A, Da Settimo F, Martini C, Taliani S, Zhu S, Wallace DC.: Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration. Aging Cell 13(3): 507-518, Jun 2014 Notes: PMID: 24977274; PMCID: PMC4076708.

Golomb BA, Erickson LC, Scott-Van Zeeland AA, Koperski S, Haas RH, Wallace DC, Naviaux RK, Lincoln AJ, Reiner GE, Hamilton G.: Assessing Bioenergetic Compromise in Autism Spectrum Disorder With P-31 Magnetic Resonance Spectroscopy: Preliminary Report. Journal of Child Neurology 29(2): 187-193, Feb 2014 Notes: PMID: 24141271; PMCID: PMC3931549.

Kenney MC, Chwa M, Atilano, SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Del Carpio JC, Nesburn AB, Boyer DS, Kuppermann BD, Vawter MP, Jazwinski SM, Miceli MV, Wallace DC, Udar N.: Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases. Biochimica Et Biophysica Acta-Molecular Basis of Disease 1842(2): 208-219, Feb 2014 Notes: PMID: 24200652.

Lott MT, Leipzig JN, Derbeneva O, Xie HM, Chalkia D, Sarmady M, Procaccio V, Wallace DC.: mtDNA Variation and Analysis Using MITOMAP and MITOMASTER. Current Protocols in Bioinformatics 1(123): 1.23.1-1.23.26, Dec 2013 Notes: PMID: 25489354; PMCID: PMC4257604

Lampe JW, Da T, Selak MA, McManus MJ, Wallace DC, Becker LB. : Critical Role For Intra-mitochondrial NADPH Generation For Survival After Cardiac Arrest: Studies In The Nicotinamide Nucleotide Transhydrogenase Deficit Mouse. Circulation 128(22), Nov 2013.

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Last updated: 05/26/2015
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