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Gary D. Wu

Ferdinand G. Weisbrod Professor in Gastroenterology
Department: Medicine
Graduate Group Affiliations

Contact information
421 Curie Boulevard
9th Floor Biomedical Research Building
Philadelphia, PA 19104
Office: 215-898-0158
A.B. (Chemistry)
Cornell University, 1982.
Northwestern University Medical School, 1986.
M.A. (Honorary)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern, University of Minnesota Hospital, 1986-1987.
Resident, University of Minnesota Hospital, 1987-1989.
Fellow (Gastroenterology), University of Michigan, Ann Arbor, 1989-1992.
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Description of Research Expertise

Research Program
Molecular regulation of gene expression in the colonic epithelium

Program Summary
Intestinal epithelial cells respond to inflammatory stimulation in several ways. First, intestinal epithelial cells can produce immune modulating substances such as cytokines and immunoreceptors. Second, intestinal inflammation leads to an alteration in the patterns of cell differentiation along the crypt-villus axis. Finally, chronic inflammatory diseases of intestinal tract lead to a markedly increased risk for the neoplastic transformation of the colonic epithelium. Using various intestinal cell culture systems and transgenic animal models, we are exploring the molecular mechanisms by which gene expression is regulated in the colonic epithelium. Target genes which are being studied in this regard include the proinflammatory cytokine, IL-8, the chloride/sulfate anion transporter, DRA, the nuclear hormone receptor, PPARgamma, and a novel gene expressed specifically in colonic crypt cells, RELM-beta.

Lab personnel:
Laetitia Charrier, PhD - Research Associate
Ying-Yu (Eddy) Chen - Research Specialist
Marie Hildebrandt, Graduate Student
Evelyn Hsu, MD - Research Specialist
Sue Keilbaugh, PhD, Technical Director, Molecular Biology Core

Selected Publications

Wu GD: The promise and challenges of biobanking in digestive disease research. Gastroenterology 136(3): 755-6, 2009.

Hsu, E., Meskill, D., Hildebrant, M.A. and Wu, G.D.: Innate and Adaptive Immunity Regulate Metabolic Responses to Parasitic Nematode Infection. Poster Presentation DDW 2009 2009.

Hildebrant, M.A., Hoffmann, C., Chen, Y.Y., Knight, R. Bushman, F.D., Ahima, R.S., and Wu, G.D. : High Fat Diet Determines the Composition of the Gut Microbiome Independent of Host Genotype and Phenotype. Oral Presentation DDW 2009 2009.

Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, and Wu GD: High fat diet determines the composition of the murine gut microbiome independently of obecity. Gastroenterology 2009.

Keilbaugh, S.A., Charrier-Hisamuddin, L., Wang, M.L. and Wu, G.D.: IGF1 Activates Goblet Cell Gene Expression via PI-3 Kinase and AKT-Dependent Pathways. Poster Presentation DDW 2009 2009.

James D. Lewis, Lichtenstein, G.L., Deren, J.J., Sands, B.E., Hanauer, S.B., Katz, J.A., Lashner, B., Present, D.H., Chuai, S., Ellenberg, J.H., Nessel, L., Wu, G.D.: Rosiglitazone for Active Ulcerative Colitis: A Randomized Placebo-Controlled Trial. Gastroenterology 134: 688-695, 2008.

Musch, M.W., Arvans, D.L., Wu, G.D., Chang, E.B.: Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3. Am J Physiol Gastrointest Liver Physiol 296(2): G202-10, 2008.

Wang, M.L., Keilbaugh, S.A., Cash-Mason, T., He, X.C., Li, L., Wu, G.D.: Immune-mediated signaling in intestinal goblet cells via PI-3 Kinase and AKT-dependent pathways. American J. Physiology-Gastro 295: G1122-30, 2008.

Wong, T., Hildebrandt, M., Thrasher, S.M., Appleton, J.A., Ahima, R.A., Wu, G.D. : Host Metabolic Responses to Intestinal Parasitic Nematode Infections: A Novel Explanation for the Evolutionary Conserved Obesity-Prone Phenotype. Oral Presentation, DDW 2007 2007.

Lewis, J.D., Lichtenstein, G. R., Deren, J.J., Sands, B.E., Hanauer, S.B., Katz, J.A., Lashner, B., Present, D., Chuai, S., Ellenberg, J.H., Nessel, L., Wu, G.D. : A Randomized, Placebo-controlled Trial of the PPAR Ligand Rosiglitazone for Active Ulcerative Colitis. DDW 2007 2007.

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Last updated: 05/01/2014
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