Mood, Anxiety and Trauma

Yvette Sheline

Section Director | Yvette Sheline, M.D.


The Mood, Anxiety and Trauma section is devoted to investigating the mechanisms underlying individual treatment response across mood, anxiety and trauma disorders. Examined broadly, we determine how various treatments including psychotherapy, psychopharmacotherapy and other neuromodulatory interventions including electroconvulsive therapy (ECT), vagus nerve stimulation  (VNS) and transcranial magnetic stimulation (TMS) produce changes in symptoms, behavior, brain activity and connectivity to improve treatment outcomes.

Center for Neuromodulation in Depression and Stress

The Center for Neuromodulation in Depression and Stress (CNDS) is devoted to investigating the mechanisms underlying individual treatment response across depression and anxiety disorders. Examined broadly, we determine how various treatments produce changes in brain activity and connectivity to improve treatment outcomes. Founded in 2013, CNDS consistently capitalizes on and augments the efforts of the outstanding neuroscience community at the University of Pennsylvania by facilitating collaboration within and across various specialties. Click here to learn more.

Center for Psychotherapy Research

The Center for Psychotherapy Research (CPR) is a research unit of the Department of Psychiatry at the University of Pennsylvania. Faculty members conduct a wide range of studies on the process and outcome of different types of psychotherapies. The primary long-term vision of CPR is driven by questions about which treatments work for what kinds of psychiatric disorders. Research in CPR is designed to test hypotheses about the means through which effective treatments work. Click here to learn more.

Center for the Treatment and Study of Anxiety

The Center for the Treatment and Study of Anxiety (CTSA) is an internationally renowned research and clinical facility that offers state-of-the-art treatment programs specifically designed for Posttraumatic Stress Disorder (PTSD), Obsessive-Compulsive Disorder (OCD), Social Anxiety (SAD), Panic Disorder (PD), Agoraphobia, Generalized Anxiety Disorder (GAD), and Specific Phobias. Founded in 1979 by Edna B. Foa, the center provides clinical services across the developmental lifespan: children, adolescents, and adults.  Treatments are tailored to each age group and are sensitive to developmental aspects of our patients. Click here to learn more.

Mood and Anxiety Disorders Treatment and Research Program

The center for Mood Disorders within the University of Pennsylvania's Department of Psychiatry provides comprehensive, state-of-the-art assessments and treatment recommendations for individuals with mood and anxiety disorders, including: bipolar disorder, major depression, dysthymia, mood disorders secondary to medical conditions and anxiety disorders. With the goal of sustained remission of the disorder, our experts provide cutting edge consultation and treatment specifically tailored to meet the needs of each individual patient, utilizing across the board therapeutic options including psychotherapy, psychopharmacology and  other neuromodulatory interventions including (electroconvulsive therapy (ECT), vagus nerve stimulation  (VNS) and repetitive transcranial magnetic stimulation (rTMS)). Click here to learn more.


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