Gastrointestinal Epithelium Modeling (GEM) Core
The Gastrointestinal Epithelium Modeling (GEM) Core is part of the GEM Program (est. 2019) - a collaborative research effort dedicated to accelerating discovery and innovation using patient-derived organoids. Our team curates and maintains a living biobank of tissue-derived organoids, complete with matched original tissue and blood specimens. We provide researchers with access to specialized training, validated protocols, and essential reagents to support organoid-based studies.
Recognizing the growing demand for human organoid culture, we officially launched the GEM Core in 2024 to expand access to these resources within the broader scientific community. The Core is currently in a gradual ramp-up phase, with ongoing efforts to expand capacity and services.
The GEM Core is funded by the CHOP Research Institute and the Penn Center for Molecular Studies in Digestive and Liver Diseases (NIH P30 DK050306).
Core Personnel
Directors:
- Kathryn E. Hamilton, PhD haka@pennmedicine.upenn.edu
- Amanda B. Muir, MD, MTR muira@chop.edu
Technical Director:
- Tatiana Karakasheva, PhD karakashet@chop.edu
Technical Specialist:
- Bella Peterson petersonb2@chop.edu
Grant Citation
Please cite the CHOP Gastrointestinal Epithelium Modeling Program, the Penn Center for Molecular Studies in Digestive and Liver Diseases (NIH P30 DK050306), and our Research Resource Identifier (RRID: SCR_026402) in all publications related to your use of our Core
Protocols
Please see our protocols.io workspace for information on the GEM core's protocols.
Services & Pricing
A list of available services and pricing for FY25 is available in this document.